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Purpose: Poor outcomes in hematologic patients have been linked to a bloodstream infection caused by Carbapenem-resistant Enterobacteriaceae. This research was designed to identify risk factors for mortality and assess the effectiveness of carbapenemases' epidemiological characteristics in determining antimicrobial therapy recommendations. Methods Hematological patients with CRE BSI between January 2012 and April 2021 were included, according to Methods. In addition, one E. coli isolate was found to have both NDM and OXA-48-like genes. Overall, 28 patients received an antimicrobial therapy containing ceftazidime-avibactam, of which 21 cases were combined with aztreonam, of which 21 patients were combined with aztreonam. The presence of septic shock at onset and pulmonary infection were independent risk factors for 30-day mortality in multivariate analysis. CAZ-AVI demonstrated a much higher survival rate than OAAs when comparing various antimicrobial regimens. If choosing CAZ-AVI, we recommend the combination with aztreonam in our center as the predominance of bla NDM.
Source link: https://europepmc.org/article/PPR/PPR552908
This article examines -omics studies using mass spectrometry to determine the molecular phenotype associated with carbapenem resistance. While the specifics of carbapenem resistance are well-characterized, the resilient phenotype is not well understood. Understanding how resistance acquisition contributes to cell differentiation and cell metabolism by molecular phenotyping is a vital step toward discovering resistance by diagnostic means. In addition, this paper explores the possibility of mass spectrometry for the detection of resistance biomarkers by molecular profiling of bacteria.
Source link: https://europepmc.org/article/MED/36105942
Local problem In a large multiorgan transplant center in Italy, an increase in the rate of health-care-associated CRE colonization was found in 2017. This study was designed to reduce the HA-CRE colonization rates by improving HH compliance. Interventions The HH Targeted Solution Tool was used to build the HH Targeted Solution Tool. The DMAIC framework was used to implement the HH Targeted Solution Tool. Conclusions DMAIC framework used to implement the TST can result in substantial improvements in HH compliance and HA-CRE colonization rates, as shown by the following tables.
Source link: https://europepmc.org/article/MED/36066885
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