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Carbapenem-resistant Enterobacteriaceae - DOAJ

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Last Updated: 02 January 2023

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Phenotypic and Genotypic Characterization of Carbapenem-Resistant Enterobacteriaceae Recovered from a Single Hospital in China, 2013 to 2017

The coexistence of CRGs with a number of other antibiotic resistance genes leads to an increase in the frequency of elevated resistance levels for CRE, u03b2-lactams, and fluoroquinolones. Conclusion: We found that long-term transmission of multiple CRE clones at this hospital between various wards was present, and that minimizing nosocomial transmission remains the most common control measure for CRE infections in China.

Source link: https://doaj.org/article/90968eac87da4fce89e551db7d459b96


High frequency of carbapenem-resistant Enterobacteriaceae fecal carriage among ICU hospitalized patients from Southern Iran

Objectiae: The worldwide outbreak of carbapenem-resistant Enterobacteriaceae has raised a significant therapeutic concern for medical institutions. No research has established the frequency and risk factors of inpatients with CRE fecal carriage in Southern Iran to date. Methods and Methods: We reviewed the characteristics of carbapenebacteriaceae-producing Enterobacteriaceae culture from 46 ICU inpatients and various follow-ups, 9 ICU scientists, and 40 environmental samples were included. Antimicrobial susceptibility was investigated by using the disk diffusion technique and E-test. Conclusions: The overall fecal carriage rate was 28. 2%, but CRE acquisitions were 6. 1%. With CRE carriage, no relationship was made between the tested risk factors. Conclusion: The results point to a high CRE fecal carriage prevalence among inpatients. Inpatients are in dire need of early diagnosis and monitoring of CRE.

Source link: https://doi.org/10.22038/ijbms.2022.63099.13938


Molecular phenotyping approaches for the detection and monitoring of carbapenem-resistant Enterobacteriaceae by mass spectrometry

This review examines the phenotype associated with carbapenem resistance using mass spectrometry. Although the specifics of carbapenem resistance are well defined, the underlying phenotype of resistance is not well understood. Understanding how resistance acquisition relates to cell culture and cell metabolism by molecular phenotyping is a key step toward determining resistance by diagnostic means. This paper, in addition, examines the possibility of mass spectrometry for the identification of resistance biomarkers by molecular profiling of bacteria.

Source link: https://doi.org/10.1016/j.jmsacl.2022.09.001


Biocompatibility, cytotoxicity and antibacterial effects of meropenem-loaded mesoporous silica nanoparticles against carbapenem-resistant Enterobacteriaceae

paraphrasedoutput:Methods Hierothoe is a bacteriaceae resistant to carbapenem-resistant Enterobacteriae. The nanoparticles are designed as new drug delivery devices and can improve the effectiveness and minimize the unfavourable effects of the antimicrobial agents. Methods is a newspaper distributed in the United States. Described herein are the manufacturing and evaluation of mesoporous silica nanoparticles treated with meropene Results of the MTT test revealed antibacterial activity on all isolates with differing MIC values lower than MICs of meropenem.

Source link: https://doi.org/10.1080/21691401.2020.1850466


Phenotypic detection and molecular characterization of carbapenem-resistant Enterobacteriaceae at a tertiary care center

Methods and Methods: Entobacteriaceae isolates were isolated by non-repetitive methods from a variety of clinical samples. All of the isolates that were found to be carbapenem-resistant by screening were exposed to a phenotypic confirmatory test in the form of a modified Hodge test. Result: Out of 1254 isolates of Enterobacteriaceae, 230 isolates were found to be positive for carbapene production by screening test. MHT has found a total of 150 out of 230 isolates tested positive for carbapenemase production. There were no isolates containing blaOXA-48 and blaKPC genes in any isolate. Conclusion: Enterobacteriaceae resistance is 11. 9 percent by phenotypically reported carbapene resistance. The production of carbapenemase genes are highly prevalent in Enterobacteriaceae Routine testing will aid in the identification of these broadly distributed pathogens and the introduction of appropriate infection control steps, thus limiting their spread.

Source link: https://doi.org/10.4103/jmms.jmms_163_20


Epidemiological Characteristics of Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae Colonization

Methods: This secondary data analysis report included 24 patients in the CP-CRE group, 113 patients in the non-CP-CRE group, and 113 in the non-CRE group. Results: The CP-CRE study showed that patients with CRE had a 17. 5% adherence rate, and Klebsiella pneumoniae was the most common causative agent in the CP-CRE group. There were no significant differences between patients in the CP-CRE and non-CP-CRE groups, although there were no significant differences between them. Patients with multidrug-resistant organisms need treatment with more thorough adherence to CRE prevention and management policies in order to prevent CP-CRE acquisition.

Source link: https://doi.org/10.1016/j.anr.2022.05.002


Increasing trends of colistin resistance in patients at high-risk of carbapenem-resistant Enterobacteriaceae

paraphrasedoutput:Methods A total of 196 multidrug-resistant Enterobacteriatic clinical isolates obtained from Gram-negative isolates over a year were found among carbapenem-resistant enterobacteriae isolates isolated over one year. This report details an examination of colistin resistance rates in carbapenem-resistant enterobacterial clinical isolates from 186 multidrug-resistant enterobacterial clinical isolates. Using the Carba NP method, Hundred isolates were carbapenemase producers. Conclusion with p = 0. 000. Permission With ESBL-producing isolates and carbapenem susceptible isolates ESBL-producing isolates, an alarming trend was observed between ESBL-producing isolates and carbapenem resistant isolates ESBL-resistant isolates. Within the clinical site of disease, antibiotic resistance is also high among carbapenem-resistant Enterobacteriaceae. The use of antibiotics is also linked to reduced use of colistin and prevents further resistance development. KEY MESSAGES CHEY MESSAGES - To minimize the use of colistin and prevent further resistance development are present in catheter-resistant Enterobacteriaceae.

Source link: https://doi.org/10.1080/07853890.2022.2129775


Does carbapenem-resistant enterobacteriaceae infection drive venous thromboembolism in patients admitted to intensive care units receiving prophylactic anticoagulants?

This report was designed to identify the risk factors related to the outbreak of VTE in patients admitted to the intensive care unit. We included all adult patients who stayed more than two days in ICU before the invention of VTE. CONCLUSION: Our findings reveal that CRE infection is a frequent source of VTE in patients admitted to the ICU, and that the treating physicians should prioritize these infections over infection-driven VTE in ICU patients.

Source link: https://doi.org/10.4103/joah.joah_151_21


Predictors of carbapenem-resistant Enterobacteriaceae (CRE) strains in patients with COVID-19 in the ICU ward: a retrospective case–control study

COVID-19 and 26 patients without COVID-19 were enrolled, with a total of 38 patients. Klebsiella spp was the majority of isolates found in COVID-19 patients. In contrast to patients without COVID-19, intensive care unit mortality in COVID-19 patients was noticeably higher among COVID-19 patients. Patients with COVID-19 increased the risk of death in patients with ICU stay. Conclusion CRE strains were more prevalent in patients with COVID-19, and they had different risks for CRE compared to patients without COVID-19.

Source link: https://doi.org/10.1177/03000605221129154


Characteristics of Carbapenem-Resistant Enterobacteriaceae in Ready-to-Eat Vegetables in China

Notably, E. coli and ST23 hypervirulent Klebsiella pneumoniae isolates of BlaKPCu22122 were found in the same cucumber sample and clonal transmission of E. coli, C. freundii, and K. pneumoniae isolates in the same vegetable species and/or cities. RNAPD plasmids from E. coli and C. freundii showed identical or highly similar RFLP profiles, and the IncX3 plasmids from cucumber showed identical or highly similar RFLP profiles, as shown in other countries, although blaKPCu22122 in K. pneumoniae was mediated by similar F35:B1 plasmids. This is the first report of either the C. freundii carrying blaNDM or K. pneumoniae harboring blaKPCu22122 in vegetables, according to our knowledge. Also the first report of a ST23 carbapenem-resistant hVKP strain in vegetables is included here.

Source link: https://doi.org/10.3389/fmicb.2018.01147

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions