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Carbamazepine - DOAJ

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Last Updated: 15 January 2023

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Association of Human Leukocyte Antigen Alleles with Carbamazepine- or Lamotrigine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in an Iranian Population: A Case-control Study

Background: A important risk factor for drug-induced severe cutaneous disease reactions among populations, including carbamazepine, lamotrigine -induced Stevens-Johnson syndrome and toxic epidermal necrolysis, is genetic variation in human leukocyte antigen alleles. CBZ- and LTG-induced SJS/TEN. Methods was a case-control study conducted in Tehran, Iran, from 2011 to 2018. Methods: A case-control study was conducted from 2011 to 2018 at various hospitals affiliated with Shiraz University of Medical Sciences. People taking CBZ or LTG for at least three months had no adverse effects, according to the drug-tolerant group. Researchers with CZB- or LTG-induced SJS/TEN were investigated to determine the presence of HLA-A, -B, and -DRB1 alleles in patients with CZB- or LTG-induced SJS/TEN. To determine a potential relationship between SJS/TEN and the HLA alleles, the Chi square test and Fisheru2019' exact test were used. However, HLA-DRB1*01 showed a significantly higher prevalence in patients with CBZ-induced SJS/TEN than those in CBZ-tolerant patients.

Source link: https://doi.org/10.30476/ijms.2022.91192.2241


A Rapid Therapeutic Drug Monitoring Strategy of Carbamazepine in Serum by Using Coffee-Ring Effect Assisted Surface-Enhanced Raman Spectroscopy

This paper aims to develop a method for CBZ detection in serum using coffee-ring effect enhanced surface-enhanced Raman spectroscopy. To minimize the effect of impurities on the silicon wafer surface and the protein matrix, surface treatment optimization of the silicon wafers and the liquid-u2013liquid extraction technique was carried out. The proposed detection method allows for the rapid determination of CBZ in chemically spiked serum samples within a concentration range of 2. 25 to u201340 u00b7mL u22121, which corresponds to the range of the drug concentrations in the serum following oral therapy.

Source link: https://doi.org/10.3390/molecules28010128


Observational studies on the efficacy of carbamazepine and ascorbyl palmitate in managing trigeminal neuralgia

OBJECTIVE: Ascorbyl palmitate is a fat-soluble vitamin C ester that is used as an antioxidant food additive and is used as an antioxidant food additive. While literature has shown that ascorbyl palmitate can prevent exacerbation of pain and improve patient quality of life of patients suffering from pain, clinical trial results are currently unavailable. The aim of our investigation was to find out how ascorbyl palmitate may help with trigeminal neuralgia. Patients with acute trigeminal neuralgia pain in the oral cavity or pain on touching trigger zones, aged 20 years or older, were unable to accurately assess the severity of pain and illness, and had suffered multiple episodes of intraoral pain for at least three months, with a pain intensity of more than four points on the numerical rating scale. CONCLUSIONS: Ascorbyl palmitate can be used as an adjunct therapy in treating trigeminal neuralgia pain.

Source link: https://doaj.org/article/0ed7909b30f64c05b3c227ca977467a2


Effects of carbamazepine on gut microbiota, ARGs and intestinal health in zebrafish

Carbamazepine in the aquatic environment has been identified as a potential threat to aquatic organisms and public health. This study was designed to investigate the effects of CBZ on gut microbiota, antibiotic resistance genes, and the expression of intestinal health-related genes, as well as their interaction using the zebrafish model. At different exposure times, we also observed the increased expression of the pro-inflammatory gene IL6 and downregulated expression of toll-like receptor gene TLR2 and intestinal barrier gene TJP2a. Our findings may help to determine the health risks of CBZ to aquatic animal intestinal microecology.

Source link: https://doi.org/10.1016/j.ecoenv.2022.114473


Fate and Toxicity of Carbamazepine and Its Degradation By-Products During Coupling of Ozonation and Nanofiltration for Urban Wastewater Reuse

Emerging organic micropolutants in water bodies and their consequences are a point of worry regarding reused water quality. Even with high ozone levels, the mineralization rate of ozonation never exceeded 12%. BQM and BQD are suspected of the toxic substances, according to Vibrio fischeri's Vibrio fischeri. With a 93 percent removal rate at 85% of permeate recovery rate, NF is able to remove total organic carbon with a removal rate of 93%.

Source link: https://doi.org/10.3389/fenvc.2021.798785


Formulation consideration and characterization of microemulsion drug delivery system for transnasal administration of carbamazepine

The aim of this research was to develop and evaluate carbamazepine-loaded microemulsion and mucoadhesive microemulsion delivery device for its intranasal administration. The drug-loaded microemulsions were developed successfully, containing 6% Labrafil M 1944 CS as an oily phase, 32% surfactant mixture of Cremophor RH 40: Transcutol P and 62% aqueous phase, with a 62% aqueous phase. In vitro mucoadhesive strength and diffusion coefficients that were higher than microemulsions, thanks to a drug-loaded mucoadhesive microemulsion with 0. 5% wt/wt of polycarbophil.

Source link: https://doi.org/10.1016/j.bfopcu.2013.07.002


Enhancement of carbamazepine removal rate using Tetradesmus obliquus KNUA061 and NaOCl and utilization of the resulting biomass

Most from sewage treatment plants, pharmaceutical and personal care products were pumped into receiving water bodies. In this research, Korean indigenous microalgae strains were tested as eco-friendly and cost-effective methods for CBZ removal. Tetradesmus obliquus KNUA061, which showed the highest CBZ removal rate was chosen for further experiments based on preliminary biological CBZ degradation results from preliminary experiments. NaOCl, a common component in the water purification process, was used as an additional stimulus to introduce stress conditions in order to raise strain KNUA061's CBZ removal effectiveness. The introduction of 1. 0 mg NaOCl at around 20 bcg Lu22121 CBZ has resulted in approximately 20% of removal rate rise without restricting cell growth. Based on the findings of the antioxidant enzyme activities, degree of lipid oxidation, and amino acid contents, it was concluded that the redox-defence system in microalgal cells may have been stimulated by the NaOCl treatment. According to Biomass' report, the heating value of strain KNUA061 biomass was higher than those of lignocellulosic energy crops, implying that it could be used as a potential renewable energy source. Despite the fact that its biodiesel qualities were marginally below international averages due to the high PUFA content, the biodiesel made from T. obliquus KNUA061 could be used as a blending resource for transportation fuels. Due to the high essential amino acid content, it was also determined that the microalgal biomass was also suitable as a sustainable dietary supplement feedstock.

Source link: https://doi.org/10.3389/fenrg.2022.1004613


The Structure of Liquid and Glassy Carbamazepine

Using Empirical Potential Structure Refinement, liquid and melt-quenched glassy carbamazepine were investigated in this paper, as well as melt-quenched glassy carbamazepine. The number of hydrogen bonds per molecule rises by 56% as a result of a 30% decrease in the close contact carbon-carbon interactions between aromatic rings during quenching from the liquid to glass. Although hydrogen-bonded dimers remain present in the glassy state, the absence of a crystalline lattice also allows small, hydrogen-bonded NH-O trimers and tetramers to develop.

Source link: https://doi.org/10.3390/qubs6040031


Simultaneous Carbamazepine and Phosphate Removal from a Moving-Bed Membrane Bioreactor Effluent by the Electrochemical Process: Treatment Optimization by Factorial Design

Pharmaceutical and personal care products are frequently used in diverse industries and introduced into water bodies from wastewater treatment plants' outlets. This study shows that treating CBZ and phosphate from the moving-bed membrane bioreactor effluent simultaneously using the electrochemical process as an advanced oxidation process. In the moving-bed membrane bioreactor system, the research includes a long-term review of CBZ treatment effectiveness and common characteristics of synthetic wastewater. The electrochemical process is then initiated as an advanced oxidation process for the simultaneous removal of CBZ and phosphate from the moving-bed membrane bioreactor's moving-bed membrane bioreactor. The electrochemical process using Pt/Ti as anode and cathode under optimal conditions resulted in as high as 56. 6 percent CBZ and 95. 95% phosphate removal, respectively, using a factorial framework.

Source link: https://doi.org/10.3390/membranes12121256


Anti‐seizure efficacy and retention rate of carbamazepine is highly variable in randomized controlled trials: A meta‐analysis

In placebo-controlled trials in epilepsy, we wanted to determine the anti-nu2010seizure efficacy of carbamazepine and retention rate. Inclusion criteria were monotherapy of CBZ in adequate dosage for epilepsy therapy and RCT duration of u22653 months. At 3 months, SFR's last update u2010 uptick ranged from 11% at 36 months to 85% at 3 months. SFR in blinded studies was 55%, up from 61% in unblinded studies. The 12 months SFR was not significantly related to the study participants' age. In blinded experiments, the combined 6 month RR in blinded studies was 59% compared to 76%. In conclusion, the SFR and RR of CBZ were highly variable in RCTs, and were particularly affected by study duration and blinding. These findings highlight the effects of RCTs' investigation of ASM, which may challenge the widespread use of CBZ as a comparator.

Source link: https://doi.org/10.1002/epi4.12644

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions