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Although numerous clinical trials are still ongoing for hematological malignancies, new research is being done to demonstrate the effectiveness of CAR T therapy in solid organ malignancies. This review article discusses current ongoing clinical trials and a few key preclinical studies involving CAR T cell therapy in solid tumors, as well as briefly discussing research findings and potential target goals that may increase the likelihood of this therapy option. We conclude by mentioning the key challenges that remain in the solid tumor environment, as well as identifying steps that may help overcome the current barriers to CAR T cell growth in solid tumors.
Source link: https://onlinelibrary.wiley.com/doi/10.1002/jha2.356
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