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"We previously used a genomic screen to find various host-associated bacteria with the predicted genetic ability to produce ZPSs related to B. fragilis, and we suspect that genetic modification of a key functional gene within these bacteria may have reduced the anti-inflammatory properties of these bacteria. " In addition, we found that macrophages stimulated with either wildtype B. fragilis or B. uniformis produced significantly more IL-10 than KOs, indicating a potentially new role of ZPS in moving the cytokine response in macrophages to a more anti-inflammatory state.
Source link: https://doi.org/10.1007/s00248-022-02037-1
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