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Cancer Immunotherapy - Europe PMC

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Last Updated: 10 June 2022

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Comparison of Pneumonitis Rates and Severity in Patients With Lung Cancer Treated by Immunotherapy, Radiotherapy, and Immunoradiotherapy

"Introduction Radiation pneumonitis is a common dose-limiting toxicity of radiotherapy to the chest in lung cancer patients. " In parallel, immune checkpoint inhibitor pneumonitis may exacerbate lung cancer's breakthrough use of immune checkpoint inhibitors to treat lung cancer, as well as checkpoint inhibitor pneumonitis. Methods We performed a retrospective chart review of 680 lung cancer patients treated with radiotherapy, immunotherapy, or both at St. Luke's University Health Network to determine pneumonitis incidence rates. Patients treated with both lung radiation and immunotherapy developed progressive disease in comparison to those who were only radiation or immunotherapy. Patients with pneumonitis grade 3 or greater were more affected by pneumonitis grade 3 or higher than those with no or low-grade pneumonitis. Future studies are required to investigate the potential relationship between symptomatic pneumonitis and poorer response to treatment, as well as whether SCC increases the risk of higher-grade pneumonitis. ".

Source link: https://europepmc.org/article/MED/PMC9167438


Immunology and immunotherapy in breast cancer.

In several clinical trials on various tumor types, drug combination therapies have already been investigated. " Breast cancer was first identified in the field of immune-oncology relatively recently. This review focuses on clinical evidence relating to immune checkpoint inhibition for curative therapy of various breast cancer subtypes.

Source link: https://europepmc.org/article/MED/35676750


Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.

"Immune checkpoint blockade therapy has greatly improved the prognosis of certain advanced-stage cancers. " Deleting the N-linked glycosylation gene ALG3 in mouse cancer cells dramatically reduced mouse tumor formation in mice in a manner that depends on cytotoxic T cells. In addition, ALG3 inhibition or N-linked glycosylation inhibitor tunicamycin treatment synergizes with anti-PD1 therapy in reducing tumor formation in mouse models of cancer. In human subjects with cancer, elevated ALG3 expression in tumor tissues is associated with poor patient survival. We present unappreciated role of ALG3 in regulating tumor immunogenicity and suggest a potential therapeutic approach for improving cancer immunotherapy.

Source link: https://europepmc.org/article/MED/35676564


Artificial intelligence-derived gut microbiome as a predictive biomarker for therapeutic response to immunotherapy in lung cancer: protocol for a multicentre, prospective, observational study.

"Introduction Immunotherapy is the fourth most common lung cancer treatment following surgery, chemotherapy, and radiotherapy. " Many studies have recently published information about the potential correlation between the gut microbiome and immune response to immunotherapy. However, the specifics of the gut microbiome or group of gut microbes that accurately predict immunotherapy's effectiveness are not certain. Methods and evaluation The current multicentre, prospective, observational research seeks to determine the exact composition of the gut microbiome or combination of gut microbes implicating lung cancer treatment by artificial intelligence. The key inclusion criteria are as follows: pathologically or cytologically confirmed metastatic or postoperative lung cancer, non-small cell lung cancer, and small cell lung cancer; age at 226520 years at the time of informed consent; planned immunotherapy including combination therapy and monotherapy as the first-line immunotherapy; and the ability to obtain fetal samples.

Source link: https://europepmc.org/article/MED/35676015


Mild phototherapy mediated by manganese dioxide-loaded mesoporous polydopamine enhances immunotherapy against colorectal cancer.

The immunosuppressive tumor microenvironment was one of the biggest challenges in using the immune checkpoint blockade to treat colorectal cancer. Owing to its superior cancer cell killing ability and immune stimulation, mild photothermal therapy has demonstrated promising results in turning tumors from immune checkpoint inhibition by turning the immunologically "cold" tumors into "hot" ones. The Mn 2+ may also promote mild photothermal treatment-induced immune response, as well as the maturation of BMDC cells. MnO 2 @MPDA-PEG NPs, according to In vivo antitumor immunization studies on a CT26 model, may be a promising dual-imaging theragnostic nanodrug to potentiate the systemic antitumor immunizations. ".

Source link: https://europepmc.org/article/MED/35670464


Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy.

"Cancer immunotherapies are based on one or two specific tumor-associated antigens. " Here we discuss the creation and application of libraries of immune cell receptors that can recognize non-self antigen receptors and display antigen-dependent clonal expansion in mouse models of epithelial tumour models. "Irin xenografts and patient-derived xenografts in mice with murine or human CAR clones were found in mice with completely eradicated established tumours in mice with murine xenografts and patient-derived xenografts in mice. ".

Source link: https://europepmc.org/article/MED/35668107


Bioengineered nanogels for cancer immunotherapy.

"Recently, immunotherapy has seen unprecedented growth and has emerged as the most effective treatment for cancer treatment, and it has mainly concerned the mobilization of the immune system and an enhanced anti-tumour immunity of the tumor microenvironment. " Nanogels are three-dimensional cross-linked aqueous materials with similar characteristics to natural tissues and are structurally stable, and they can safely deal with shear forces and serum proteins in the bloodstream, increasing the risk of nanogel accumulation in the tumor, which leads to deep tumour penetration. The large surface area allows multiple physical and chemical changes for specific immune cell subpopulations or immune organs to be more or eliminate off-target effects by introducing stimuli-responsive functional groups, increasing the bioavailability of the drug, and causing a low incidence of nanogel therapies. Nanogel-based immunotherapy has been widely used "as an effective treatment for cancer immunotherapy. ".

Source link: https://europepmc.org/article/MED/35666131


Comparison of Pneumonitis Rates and Severity in Patients With Lung Cancer Treated by Immunotherapy, Radiotherapy, and Immunoradiotherapy.

"Introduction Radiation pneumonitis is a common dose-limiting toxicity of radiotherapy to the chest in lung cancer patients. " In addition, immune checkpoint inhibitor pneumonitis can impede the clinical use of immune checkpoint inhibitors to treat lung cancer. Methods We conducted a retrospective chart review of 680 lung cancer patients treated with radiotherapy, immunotherapy, or both at St. Luke's University Health Network to determine pneumonitis incidence rates. Compared to those treated with only radiation or immunotherapy, more of the patients treated with both lung radiation and immunotherapy developed progressive disease. Patients with pneumonitis grade 3 or higher were more likely in patients with pneumonitis grade 3 or higher than those with no or low-grade pneumonitis. Future studies are required to determine the possible correlation between symptomatic pneumonitis and poorer response to treatment, as well as whether SCC elevates the risk of high-grade pneumonitis. ".

Source link: https://europepmc.org/article/MED/35677739


Sperm-specific proteins: new implications for diagnostic development and cancer immunotherapy.

"These new results have clinical implications for diagnostics and therapeutics targeting a specific class of proteins known as cancer-testis antigens ("checking new communication channels in the testis, and finding new ways to monitor testis function. ".

Source link: https://europepmc.org/article/MED/35671587

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions