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"Cancer biology is a complex system that results from genetic mutations in key tumor oncogenes and suppressor genes for cell proliferation, DNA replication, cell differentiation, and homeostatic functions. " Although scientific research in recent decades has shown how the genome sequence has mutated in several cancers, high-order chromosomal structures involved in tumor formation, and fate of cancer cells, a key yet little explored part of cancer genomics. In summary, dissection of the 3D genome conformation of cancer helps understand the distinctive epigenetic signatures and gene regulation processes that distinguish cancer biology from normal physiological states. Tumor 3D genomics research has exploded in recent years. We can now better determine the correlation between cancer pathogenesis and tumor cell chromatin structure thanks to 3D genomics' rapid growth. This essay explores the relationships between tumor gene expression regulation, tumor 3D chromatin structure, and cancer phenotypic plasticity.
Source link: https://doi.org/10.3389/fcell.2022.879465
"Filopodia are cellular protrusions that respond to a variety of stimuli. " When actin is bound to the protein Fascin, a key component in cell interactions and motility during cancer metastasis, Filopodia are formed. With this multidisciplinary approach, researchers and clinicians will gain the most current in-formation on fascins' role in cancer progression, which may lead to clinical applications in the future. ".
Source link: https://doi.org/10.1016/j.bbadva.2022.100052
"To investigate the expression levels of miR-488, miR-29c-3p, and growth differentiation factor 15 in colon cancer tissue" and explore their association with clinicopathologic findings in patients with colon cancer. " The colon cancer tissues and the adjacent tissues were more than 5 cm when they were removed from the cancer tissues by qRT-PCR, and GDF15 mRNA in colon cancer tissues were detected by qRT-PCR. The amount of miR-488 in colon cancer tissues was lower than that in nearby tissues, but the levels of miR-29c-3p and GDF15 mRNA in colon cancer tissues were higher than those in adjacent tissues. The expression rates of miR-29c-3p and GDF15 proteins in colon cancer tissues were higher in comparison to paracancerous tissues.
Source link: https://doi.org/10.1155/2022/2138954
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