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Complement - BioProject

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Last Updated: 24 January 2022

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Sodium Iodate-Induced Degeneration Results in Local Complement Changes and Inflammatory Processes in Murine Retina

Although there has been promising in the treatment of AMD's neovascular form of the disease, no treatment for the more common dry form, also known as geographic atrophy, is yet available. To learn the cause, we investigated retinal tissue in a mouse model of retinal degeneration caused by sodium iodate-induced retinal pigment epithelium atrophy. NaIO3 caused patchy RPE loss and thinning of the photoreceptor layer. At day 10, retinal degeneration was upregulated in retinal degeneration. Proinflammatory ccl-2, -3, -5, il-33, and tgf-b's retinas were elevated in NaIO3 mice's retinas, but vegf-a mRNA were reduced. Local retinal inflammatory changes in the NaIO3 retina may have arisened by local retinal inflammation changes. Macrophages, microglia, and gliotic Mueller cells may be a cellular source for local retinal inflammatory changes in the NaIO3 retina. In this model of NaIO3-dependent retinal degeneration, systemic complement and cytokines/chemokines remained unchanged, although cytokines/chemokines remained unchanged.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/781828


Effects of the sex chromosome complement, XX, XO or XY, on the transcriptome and development of mouse oocytes during follicular growth.

X chromosome dosage-dependent expression in numerous X-linked genes is sensitive to X chromosome dosage-dependent expression. In XY oocytes, the transcriptome field is closer to XX oocytes than XO oocytes. In XY oocytes, genes are unusually expressed relative to XX or XO oocytes, compared to XX or XO oocytes. Conclusions: The differences in XY oocytes became more apparent, causing them to differ from XX or XO oocytes near the end of the growth cycle. Overall scheme: During follicular growth, Transcription of XX, XO, and XY mouse oocytes during follicular growth.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/763388

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions