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Objective Segmentectomy has been suggested as an alternative to lobectomy for small-sized NSCLCs that have no detriment to life. There have been no evidence that segmentectomy over lobectomy on pulmonary function for long-term results. This meta-analysis aims to examine postoperative changes in pulmonary function in NSCLC patients undergoing segmentectomy or lobectomy. Both segmentectomy and lobectomy were compared in clinical outcomes. FEV1 [10 studies, P 0. 01, WMD = 0. 40], FVC [4 studies, P 0. 01, WMD = 0. 01 ], and DLCO [3 studies, P 0. 1 ], WMD = 0. 40 ], and FVC [4 studies, P 0. 01, WMD = 1. 30 ], FVC [4 studies, P 0. 01, WMD = 0. 1 ], [2 studies, P FVC [4 studies, P 0. 40 0 [4 studies, P 0. 40 0. 40 0. 20 [4 patients, WMD = 0. 40 0. 20 0. 20 0. 40 0. 40 FVC [1 FVC 0. 40 1. 01 [4 studies, WMD = 0. 40 FVC 0. 01 0. 40 0. 20, P 0. 01 0. 01 0. 40 1 0. 10 More lung function than lobectomy can be maintained by segmentectomy. In the segmentectomy group, there were significantly smaller decreases in FEV1, FVC, FVC%, FEV1/FVC%, FEV1/FVC, FEV1/FVC%, FEV1/FVC, FEV1/FVC%, FEV1/FVC, and DLCO than in the lobectomy group, despite the fact that in the lobectomy group.
Source link: https://europepmc.org/article/MED/35526006
Although T cell receptor-modified T cell therapies have shown promise against solid tumors and lymphote, solid tumor formation in vivo has been limited, overall clinical benefits in clinical practice have been modest due in part to suboptimal T cell retention and activation in vivo, as well as the possibility of tumor antigen escape. In vivo regeneration of adoptively transferred TCR-T cells and in situ priming of the endogenous anti-tumor T cell repertoire was combined with TCR-T cell therapy. Enhanced anti-tumor response was still linked to pro-inflammatory lymph node transcriptional reprogramming and increased antigen presenting cell maturation, leading to TCR-T cell expansion and functional improvement in lymph nodes and solid tumor parenchyma without lymphodepletion. In vitro testing of AMP-peptides with identical human TCR-T cells in NY-ESO-1, mutant KRAS, and HPV16 E7 demonstrated the clinical benefits of AMP-vaccination to improve human TCR-T cell proliferation, activation, and anti-tumor activity.
Source link: https://europepmc.org/article/PPR/PPR489485
In two animal models with different etiologies: the RCS and the P23H-1 rats, the aim is to investigate and compare the effects of syngeneic bone marrow mononuclear stem cell transplants on inherited retinal degeneration. At post-natal day 21, a suspension of BM-MNCs was injecting subtly or intravitrelly in the left eyes of P23H-1 and RCS rats' left eyes. The retinas were cross-sectioned, and photoreceptor survival and glial cell responses were investigated at different time points after the injection: 7, 15, 30, 60, and 60 days, according to the researchers, and glial cell proliferation and glial cell responses were investigated using immunodetection of cones, synaptic connections, microglia, astrocytes, and Müller cells. In Müller cells, both IVIs and SRIs elevated photoreceptor survival, decreased synaptic degradation, and glial fibrillary acidic protein expression, but did not change microglial cell activation and migration, nor did not influence electroretinographic responses. Intravitreal and subtinal syngeneic BM-MNC transplantation reduces photoreceptor degeneration and has anti-gliotic effects on Müller cells, but does not improve retinal function.
Source link: https://europepmc.org/article/MED/35514078
Several hundreds of genes are overexpressed in a common breast cancer cell, and their overexpression is often thought to have a pro-cancer function, but what percentage of these overexpressed genes plays a role in stimulating and maintaining tumorigenicity is unknown. To answer this question, we screened an independent group of seventy-five genes overexpressed in breast cancer for their ability to promote malignant transformation and breast cancer cell expression independence. We discovered that CEACAM5 overexpression conferred tumorigenicity to pre-malignant mammary epithelial cells and that reduced expression largely reduced luminal breast cancer cell lines. We also established that CEACAM5 overexpression promoted cell number rise in 3D spheroid culture by a novel method that increased the number of epithelial cell layers from a single layer to multiple layers.
Source link: https://europepmc.org/article/PPR/PPR489046
Our aim was to investigate the effect of the gingival crevicular fluid from pregnant women on trophoblast cell function and trophoblast-neutrophil interaction. Method of analysis The study's aim was to determine gingivoperiodontal clinical score estimation and GCF analysis of pregnant women at 16-20 weeks of gestation and non-pregnant women as the control group. The effect of each GCF sample was assessed on first trimester trophoblast-derived cells to determine cell migration, cytokine expression, and glucose uptake. Also, the effect of GCF on human peripheral neutrophil chemoattraction by trophoblast cells and ROS formation was investigated. Result GCF from pregnant women decreased trophoblast cell migration, increased proinflammatory marker synthesis, and glucose uptake. Only the GCF from pregnant women aided neutrophil chemoattraction after conditioning of trophoblast cells with GCF. GCF from pregnant women is deleterious for first trimester trophoblast cell function, according to the authors.
Source link: https://europepmc.org/article/MED/35511077
The aim of this research was to explore the role and related mechanism of chordin in oral squamous cell carcinoma. Conclusions The mRNA level in OSCC was much lower than that in normal tissues, but the protein level was much higher than that in normal tissues. CHRDL1's high mRNA levels resulted in a poor prognosis in patients with OSCC. CHRDL1-positively related with CHRDL1, while Tgd was negatively related to CHRDL1. In addition, we found that hsa-miR-455-3p directly attacked CHRDL1 and reduced the CHRDL1's mRNA levels.
Source link: https://europepmc.org/article/MED/35510812
We investigated how GB cells obtained stem cell-like phenotypes in somatic cells by utilizing ribosomal proteins because ribosome incorporation has been reported to produce stem cell-like phenotypes in somatic cells. We hope that the dysregulation of ribosome biogenesis and extra-ribosomal function in GB will provide new insight into GB cells' plasticity, heterogeneity, and therapeutic resistance, which may lead to new therapeutic approaches.
Source link: https://europepmc.org/article/MED/35508789
We wanted to investigate the prevalence of functional deficits and symptoms in a cohort of people with PCDs and associations of demographic, disease-related, functional, and psychosocial indicators that improve quality of life. Patients of Cancer's QoL questionnaire completed a functional assessment and the European Organization for Research and Treatment of Cancer QoL questionnaire. Both the median and latest declines were lower mean QoL scores, with 11% having received 4th-line therapy. Patients 6 months from diagnosis had lower QoL than those 2 years since diagnosis. However, patients on later lines of therapy had lower QoL than those on 1st-line therapy. Patients with physical impairments and more advanced PCDs had lower QoL than those without deficit or earlier in their disease course, according to the authors. Early detection of physical impairments may lead to interventions that eliminate these deficiencies and, therefore, raise QoL for patients with PCDs.
Source link: https://europepmc.org/article/MED/35511734
Purpose Bronchiolitis obliterans syndrome is a leading cause of morbidity and mortality in lung transplantation and allogeneic stem cell transplantation recipients. BOS testing should be done quickly, according to clinical guidelines, but real-world rates of pulmonary function testing have yet to be investigated. The aim of this study was to determine PFT rates in lung transplantation and allo-HSCT recipients. Results include: 367 commercially insured and 1776 Medicare recipients who underwent lung transplantation; 92% and 86% failed a 1 lung function test in the first year after transplantation, respectively, according to the survey. In the first posttransplant year, 44% and 36 percent of the 2187 commercially insured and 1864 Medicare beneficiaries who underwent allo-HSCT, 44% and 36% showed a 1 lung function test. Implications Morbidity and Mortality from BOS are still high among lung transplant and allo-HSCT recipients, but lung function testing in the first posttransplant year is not universal, with significantly lower rates among allo-HSCT recipients.
Source link: https://europepmc.org/article/MED/35513911
Introduction Human umbilical cord-derived mesenchymal stem cells are one of the most effective cell therapy therapies used to treat ischemic heart disease. Cell sheet engineering has been used to transplant stem cells and enhance their therapeutic efficiency. We wanted to investigate the efficiency of UC-MSC sheets in the treatment of chronic ischemic heart disease. UC-MSC sheets were made from UC-MSCs using temperature-responsive culture dishes. These sheets were transplanted onto the epicardial surface of the infarct heart in rat models of chronic ischemic heart disease. The cardiac function of the UC-MSC sheets group was much higher than that of the exception and myocardial infarction only groups, according to an echocardiography report published at four weeks after transplantation. Conclusions UC-MSC sheets can maintain cardiac function and attenuate ventricular remodeling in chronic heart failure with ongoing ischemic heart failure, indicating that this therapy may be a promising therapeutic option in the clinical setting.
Source link: https://europepmc.org/article/MED/35513020
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