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CELL Function - Astrophysics Data System

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Last Updated: 10 May 2022

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Halide exchange in the passivation of perovskite solar cells with functionalized ionic liquids

Application of additives to perovskite precursor solutions is an easy way to passivate perovskite films for the production of perovskite solar cells with increased power-conversion efficiencies and improved stability. The mechanistic explanation for the passivation effect of the IL's perovskite films in the perovskite films is given. The fabricated PSCs containing perovskite films with the ILs are shown to have high PCEs and high stability, with the unencapsulated units retaining 95% of their original efficiencies after 1,000 h.

Source link: https://ui.adsabs.harvard.edu/abs/2022CRPS....300848G/abstract


Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

By copping normal stem cell cultures, cancer stem cells frequently obtain the ability to self-renew and persist in their hosts. In BC chronic myeloid leukemia, clinical trials with MNK kinase inhibitors are deemed appropriate, according to our findings.

Source link: https://ui.adsabs.harvard.edu/abs/2013PNAS..110E2298L/abstract


Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells

Induced pluripotent stem cells can be generated from somatic cells by a defined set of genetic factors, but mice's genetic mutation, as well as their ability to contribute to high-grade chimerism, can be hindered by aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster. We describe an operation that allows splenic B cells that are stimulated by Ig heavy-chain class-switch recombination to be reprogrammed into iPSCs that contribute to high-grade chimerism in mice. IgM to IgG1 and IgE can be converted from IgM to IgG1 and IgE in a culture of nave splenic B cells in culture with anti-CD40 plus IL-4. These conditions enabled us to breed chimeric mice in which all mature B cells were derived solely from iPSCs produced by IgG1-expressing B-cells. The effect of resultant iPSCs can be influenced by the culture conditions of activated B cells before and during reprogramming.

Source link: https://ui.adsabs.harvard.edu/abs/2012PNAS..10913745W/abstract


Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells

Human lung disease research in vivo or in vitro are currently lacking. This layer contains Clara cells with Clara cell 10 kD-positive vesicles, mucin 5A/C-positive goblet cells, multiciliated cells, and isolated cells with fibrosis transmembrane regulator inhibitor 172.

Source link: https://ui.adsabs.harvard.edu/abs/2014PNAS..111E1723F/abstract


HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function

Herman LTR-associating protein 2 is a member of the B7 family with a 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and a subfamily with B7x and B7-H3 within the family, but phylogenetically groups a subfamily with B7x and B3-H3 within the family. After stimulation with LPS and IFN-, human monocytes are constitutively expressed on the surface of human monocytes and is inducing on B cells. HHLA2 does not collaborate with other well-known members of the CD28 family or B7 family, but it does bind a putative receptor that is not limited to resting and activating CD4 and CD8 T cells but also on antigen-presenting cells. In the absence of T-cell receptor signaling, HHLA2 inhibits proliferation of both CD4 and CD8 T cells. Hence, we have found a unique B7 pathway that is capable of blocking human CD4 and CD8 T-cell proliferation and cytokine production.

Source link: https://ui.adsabs.harvard.edu/abs/2013PNAS..110.9879Z/abstract


Beta-lactam antibiotics modulate T-cell functions and gene expression via covalent binding to cellular albumin

In vitro and in vivo on T-cell-mediated experimental autoimmune diseases, we investigated the effects of commonly used beta-lactam antibiotics on rodent and human T cells. The effect was obvious: an anti-myelin basic protein T-cell line treated with cefuroxime or penicillin was more encephalitogenic in adoptive transfer experiments. Several genes involved with T helper 2 and T regulatory differentiation were down-regulated in T cells stimulated by cefuroxime, according to gene expression analysis; these genes were up-regulated in the presence of ampicillin. Human and rodent T cells expressed albumin mRNA and protein, while rodent T cells secretly produced penicillin-modified albumin, which led to enhanced encephalitogenicity. Beta-lactam antibiotics in wide clinical use have demonstrated positive results on T-cell function, and beta-lactam antibiotics can act as immunomodulators, presumably by covalent binding to albumin.

Source link: https://ui.adsabs.harvard.edu/abs/2013PNAS..110.2981M/abstract


Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes

Tumor suppressor p53 has been shown to have a wider function than just energy metabolism control. In both streptozotocin-induced type 1 and db mouse models of type 2 diabetes, we investigated the role of islet p53 and discovered that genetic and pharmacological inhibition of p53 maintains insulin secretion and glucose tolerance.

Source link: https://ui.adsabs.harvard.edu/abs/2014PNAS..111.3116H/abstract


Extracellular matrix proteins regulate NK cell function in peripheral tissues

Natural killer cells detoxify class I's earliest histocompatibility complex class I – deficient bone marrow through direct cytotoxicity, but not solid organ transplants devoid of MHC-I. Combined with missing self MHC-I, an NK cell-specific activating ligand and missing self MHC-I resulted in complete graft rejection, resulting in complete graft rejection, which was dependent on NK cells as potential mediators and T cells as effectors. MHC-I-deficient melanoma in the skin was markedly elevated by blocking tumor collagen deposition. Collagen and elastin can modulate NK cell effector function in peripheral tissues, ranging from direct cytotoxicity to helper phenotypes.

Source link: https://ui.adsabs.harvard.edu/abs/2022SciA....8K3327B/abstract


Oral Administration of a Select Mixture of Bacillus Probiotics Affects the Gut Microbiota and Goblet Cell Function following Escherichia coli Challenge in Newly Weaned Pigs of Genotype MUC4 That Are Supposed To Be Enterotoxigenic E. coli F4ab/ac Receptor Negative

Low, moderate, or high doses of Bacillus licheniformis - B. subtilis mixture were orally administered to piglets of genotype MUC4 that are supposed to be F4-expressing enterotoxigenic Escherichia coli strain F4b/ac receptor negative for a week before the F4+ ETEC challenge was announced. Following F4 + ETEC strain in pigs treated with low-dose BLS mix, the Clostridium and Turicibacter populations increased. After the administration of BLS mixture during E. coli infection, Lactobacillus gasseri and Lactobacillus salivarius populations increased. To treat enteritis, oral administration of BLS mix reprograms the gut microbiota and boosts goblet cell function, according to our results. Bacillus licheniformis-B's low, moderate, or high doses are present in this report. To treat enteritis, oral administration of BLS mix reprograms the gut microbiota and boosts goblet cell function, according to our results.

Source link: https://ui.adsabs.harvard.edu/abs/2017ApEnM..83E2747Z/abstract


Effect of Laser Irradiation on Cell Function and Its Implications in Raman Spectroscopy

ABSTRACT Lasers are used in advanced bioimaging and Raman spectroscopy. To perform cell analysis and manipulation, such as Raman-activated cell sorting, it is essential to determine nondestructive conditions for living cells. Here, we analyzed quantitatively the effect of 532-nm laser irradiation on bacterial cell fate and growth at the single-cell level. Laser irradiation can harm cell metabolism, and cell function can be compromised, and the degree of damage can vary from reduced cell growth to complete loss of cell metabolic activity and finally to physical disintegration. Gram-positive bacterial cells are more susceptible to irradiation-induced damage than Gram-negative bacterial strains. We have evidence of nondestructive characteristics of Raman spectroscopy on individual bacterial cells by specifically relating Raman acquisitions to single-cell growth characteristics. However, although strong Raman signals can be obtained without causing cell death, the variety of responses from various strains and cells indicates that careful monitoring of Raman acquisition conditions is vital. IMPORTANCE IN RAMAN spectroscopy The use of a broad monochromatic light in laser-based instruments, in particular weak signals, aids in the detection of inherently weak signals. Raman measurements are particularly useful because, unlike label-based fluorescence techniques, it gives a "fingerprint" that is specific to the identity and state of any sample. The study presented here is a qualitative review that provides a single platform and methods to investigate the effects of laser irradiation on individual bacterial cells.

Source link: https://ui.adsabs.harvard.edu/abs/2018ApEnM..84E2508Y/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions