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Bronchitis - Crossref

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Last Updated: 10 September 2022

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Genotyping and In Silico Analysis of Delmarva (DMV/1639) Infectious Bronchitis Virus (IBV) Spike 1 (S1) Glycoprotein

The genetic variation and evolution of infectious bronchitis virus are mainly influenced by mutations in the spike 1 gene. These variant aa residues were not subjected to positive selection pressure in the hypervariable regions of the IBV/Ck/Can/2558004 protein of IBV/Ck/Can/2558004 in comparison to U. S. DMV/1639 isolates, according to a more homology report of a sequence. In addition, bioinformatic analysis revealed that some of the changes inside the S1 protein of IBV/Ck/Can/2558004's S1 protein had been expected to influence the S1 protein's function and structure, possibly leading to a reduced binding affinity of the S1 protein to its key ligand.

Source link: https://doi.org/10.3390/genes13091617


Proteomic analysis of bronchoalveolar lavage fluid samples obtained from West Highland White Terriers with idiopathic pulmonary fibrosis, dogs with chronic bronchitis, and healthy dogs

u2014 To determine potential biomarkers for IPF, test protein expression in bronchoalveolar lavage fluid obtained from West Highland White Terriers with idiopathic bronchitis, dogs with chronic bronchitis, and healthy control dogs. Samples from 6 West Highland White Terriers with histologically confirmed IPF, 5 dogs with persistent bronchitis, and 4 healthy Beagles were found. Proteins that were differentially expressed relative to those for healthy control dogs were discovered by mass spectrometry and then confirmed by western blotting. Resultu2014Expression of 6 proteins was upregulated and that of 1 protein was downregulated in dogs with IPF or chronic bronchitis, compared to those for healthy dogs. Protomes from dogs with IPF and chronic bronchitis showed similar results for the dogs with IPF and chronic bronchitis, which suggested a common response to disease processes in otherwise different lung diseases.

Source link: https://doi.org/10.2460/ajvr.74.1.148


Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related”

A. D. A. (British Columbia) Platycodon grandiflorus A. DC. Root is one of Asia's most commonly used medicine-food products for respiratory discomfort, usually in the form of a decoction or leaching powder. In PG decoction against chronic bronchitis and the mechanism behind, this research sought to explore the synergistic effects of Platycodon grandiflorus polysaccharide and platycodin D. PGP had synergistic results with PD on improving the histopathological susceptibility, mucus secretion excess, and immunological imbalance in lung of CB model rats, which was closely related to its variations on mucosal immunity status in small intestine. The polysaccharide macromolecules in PG's decoction or leaching solution may have been responsible for the modulation of pulmonary immune state, perhaps through the common mucosal immune response between small intestinal and lung. These results may provide a new perspective on traditional Chinese medicine's classical theory of u201ctuous lung and intestine are closely related. u201d.

Source link: https://doi.org/10.3389/fphar.2022.927384


COPD, airflow limitation and chronic bronchitis in farmers: a systematic review and meta-analysis

Introduction Continued airflow limitation and persistent respiratory signs are among the common causes of chronic obstructive pulmonary disease (CR). Using the most commonly used disease classifications, this meta-analysis sought to determine the relationship between agricultural work and COPD. Two studies determined only the presence of airflow restriction, while eight others focused on the prevalence of both these conditions, while four others assessed only the incidence of chronic bronchitis. According to the new definition, only one assessed COPD based on its current definition, and this report also reported the incidence of airflow limitation. Ten studies reported a positive correlation between farming exposure and airflow limitation or chronic bronchitis, with no correlation uncovered. Conclusions Although some aspects of COPD are related to some agricultural research, well-designed studies with appropriate diagnostic criteria should be done to draw strong conclusions about the relationship between COPD and farming.

Source link: https://doi.org/10.1136/oemed-2018-105310


Protective Efficacy of Different Live Attenuated Infectious Bronchitis Virus Vaccine Combination against Challenge with GI11 (BR-Type) Strain

The infectious bronchitis virus is an avian coronavirus that causes a highly infectious disease that has resulted in major economic losses to the poultry industry around the world. We conducted an experimental experiment to compare two vaccination programs on behalf of a virulent strain of the GI-11 genotype isolated in Brazil using two separate Mass-type vaccines mixed with a BR-type live vaccine. At 4 and 11 dpv, the MLV+BR-Type group had the highest number of BR strain vaccine and the least amount of Mass strain vaccine in tracheal and cloacal swabs. In both samples tested, the Ma5+BR-type group had less BR-type positives. MLV+BR group showed a higher titer of antibodies determined by ELISA after the challenge, but MLV+BR group had a higher titer of antibody measured by ELISA. When used in conjunction with BR vaccine development, the selection of a Mass-type vaccine strain can play a direct role in the BR vaccine replication, as well as the induction of humoral immune response.

Source link: https://doi.org/10.23880/vij-16000280


Validation of a Clinical Instrument for Measuring the Severity of Acute Bronchitis in Children – The BSS-ped

Background: There are no validated clinical protocols for acute bronchitis detection in children. If it is valid, the u201cBSS-pedu201d, a brief version of the physician-rated assessment scale BSS, may fill the void. Methods: Investigations were planned according to established clinical-psychometric validity standards, including a formal competency review of the scale-u00b4s authors and statistical evaluations of data from 78 patients aged 1-6 and diagnosed with bronchitisu201d. u201d Analysis of results from 70 children with matching age, sex, and diagnosis confirmed cross-validation. The BSS-ped was used three times in comparison to other medical and psychometric testing methods. An acute bronchitis outbreak under placebo and an active drug were correct, according to a new prognose. BSS-ped is a reliable method for determining the severity of acute bronchitis in children.

Source link: https://doi.org/10.2174/1874306401812010050


Roles of Ambient Temperature and PM2.5 on Childhood Acute Bronchitis and Bronchiolitis from Viral Infection

The human respiratory syncytial virus that causes seasonal acute bronchitis and bronchiolitis in children is linked to environmental change and air pollution, according to studies. With PM2. 5 > 37. 0 bcg/m3 and decreased to 536 cases/day on a daily basis, as PM2. 5 was a determinant of 15. 0 mm3/m3 in 2007 at u236530. In conclusion, CABs infections in children were attributed to lower ambient temperatures and elevated PM2. 5 levels, and the high PM2. 5 levels coincided with low temperature levels.

Source link: https://doi.org/10.3390/v14091932


Infectious bronchitis virus attaches to lipid rafts and enters cells via clathrin mediated endocytosis

ABSTRACT Because of its economic value to the poultry industry, the origins of infectious bronchitis virus have been investigated extensively. We discovered that lipid rafts were involved in IBV attachment first. We found that IBV mainly used the CME for its entry by using a specific clathrin-mediated endocytosis blocker or knock down of clathrin heavy chain. Surprisingly, CME adaptor Eps15 had no effect on IBV internalization. The incorporation of IBV in cells led to active cytoskeleton rearrangement in third. After internalization, virus particles continued with the traditional endosome/lysosome route, as shown by co-localization of R18 labeled IBV with vehicle markers Rab5/Rab7/LAMP1 alongside the infection time course. Our results, however, show that IBV virions adhere to lipid rafts and are internalized into cells by CME, persist with early/late endosomes-lysosome membranes, and release virus genome into cytoplasm. According to the release of IBV, the introduction of IBV requires low pH. When clathrin-mediated endocytosis was blocked by a chemical inhibitor or depletion of clathrin protein, IBV entry was significantly delayed, according to our findings. IBV fused with late endosomes or lysosomes, according to the R18/DiOC labeling scheme. This is the first study to describe the entire entry process of IBV, allowing for a more complete account of group III avian coronavirus infection.

Source link: https://doi.org/10.1101/352898


Small Airway Dysfunction in Chronic Bronchitis with Preserved Pulmonary Function

In chronic bronchitis patients with impaired ratio impaired spirometry, an impairment of pulmonary function was investigated. Between October 2014 and September 2017, we retrospectively collected clinical evidence from 157 chronic bronchitis and 186 chronic obstructive pulmonary disease patients. Only patients in accordance with the Global Initiative for Chronic Obstructive Lung Disease grades 1 and 2 were accepted, owing to small airway function in the COPD study. PRISm is a nonspecific pattern of respiratory function that may indicate small airway dysfunction and can raise the chance of conversion to obstructive ventilation dysfunction.

Source link: https://doi.org/10.1155/2022/4201786


Associated risk factors and diagnostic value of fiberoptic bronchoscopy for protracted bacterial bronchitis in children

Objective: Goal: A chronic bronchitis bronchitis, a common wet cough in children, may lead to chronic suppurative lung disease or bronchiectasis. However, PBB diagnostic criteria for PBB are nonspecific, so PBB may be misdiagnosed. Children with persistent cough at First Affiliated Hospital of Anhui Medical University from January 2015 to May 2020 were registered and referred to a suspected PBB or a non-PBB group, according to a non-PBB or a non-PBB group. Biological lavage and sputum samples were cultured in children with suspected PBB at FOB with bronchoalveolar lavage; bronchoalveolar lavage. The test revealed that the majority of the 347 children had persistent wet cough for about two months. 140 of 141 children with suspected PBB, 140 of 141 were FOB with bronchoalveolar lavage. Sputum was most prominent in the left main bronchus, left lower lobe, right upper lobe, and right lower lobe. Sputum properties and amounts were significantly different between children with PBB vs. those without PBB.

Source link: https://doi.org/10.22541/au.166114987.73653273/v1

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions