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Tumor-associated macrophages play a significant role in regulating mammary tumor formation and in determining tumor infiltrating leukocyte responses in the microenvironment. In this research, we find that the activation of the RON receptor tyrosine kinase signaling pathway specifically in macrophages aids breast cancer formation and metastasis. We show that loss of macrophage RON expression results in decreases in mammary tumor cell proliferation, survival, cancer stem cell self-renewal, and metastasis in using clinically relevant murine models of breast cancer. We now show that macrophage RON expression controls the macrophage secretome, which includes IL-35 and other immunosuppressive factors.
Source link: https://doi.org/10.1038/s41388-021-02091-y
Many procedures to induce Cre-ER transgenes, including oral gavage, IP injection, or intragastric injection, are all required for transgene induction in mice. As a result, the documented metabolic benefits of tamoxifen therapy are not always consistent with anecdotal data from breast cancer patients or with expected outcomes based on the overall metabolically protective role of estrogen.
Source link: https://doi.org/10.1210/endocr/bqab126
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