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Breast Cancer - Springer Nature

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Last Updated: 10 May 2022

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ASO Author Reflections: Broaden the Targeted Population of Synthetic Lethality for Taiwanese Breast Cancer

Polymerase inhibitors selectively cause DNA single-stranded break repair, but not impact double-stranded break repair. The impact of individual homologous recombination genes can vary, based on different estimates, and the possibility of PARP inhibitors can be clarified when further research into the effect of individual homologous recombination genes is conducted.

Source link: https://doi.org/10.1245/s10434-022-11407-5


The Effect of Age on Outcomes After Neoadjuvant Chemotherapy for Breast Cancer

Background Younger women with breast cancer who are receiving neoadjuvant chemotherapy have higher rates of pathological complete response; however, it is unclear if axillary or breast downstaging rates differ by age. Methods We found 1383 women with stage I-III breast cancer treated with NAC and subsequent surgery from November 2013 to December 2018, with pCR and breast/axillary downstaging rates measured and compared across age groups. Overall, pCR rates did not change by age, however, younger women had higher pCR rates and were more likely to have tumors with elevated tumor-infiltrating lymphocyte concentrations in patients with TN tumors. The conversion from breast-conserving surgery eligibility to infanticide surgery was similar among initial BCS-ineligible patients; younger women chose BCS less often. Despite similar breast downstaging and BCS eligibility rates among age groups, younger women were less likely to have BCS.

Source link: https://doi.org/10.1245/s10434-022-11367-w


Cognitive Functioning and Health in Hispanic/Latina Breast Cancer Survivors

In a cross-sectional design study, we investigated the effect of waist-to-hip ratio, body mass index, diet, and physical fitness on cognitive stability among Hispanic/Latina breast cancer survivors. Participants included 54 Hispanic/Latina breast cancer survivors and completed the NIH Toolbox Cognition Battery, with 54 Hispanic/Latina breast cancer survivors and the NIH Toolbox Cognition Battery. Linear regression models were tested to see if statistically significant correlations existed among covariates. These results showed a positive correlation with increased MVPA and harder intensity physical exercise to improved cognitive function among Hispanic/Latina breast cancer survivors.

Source link: https://doi.org/10.1007/s10903-021-01300-w


BMP4 enhances anoikis resistance and chemoresistance of breast cancer cells through canonical BMP signaling

To determine the hormonal effect of BMP4 on breast cancer, we used breast cancer cell lines and clinical samples from several subtypes. In MDA-MB-231 breast cancer cells, stem cell genes CD44, ALDH1A3, anti-apoptotic gene BCL2, and promoted anoikis resistance have been enhanced by stem cell gene expression. In MDA-MB-231's upregulating Notch signaling, improving self-renewal and chemoresistance, while LDN therapy abrogated anoikis resistance and proliferation of anoikis resistant breast cancer cells in the osteogenic microenvironment. BMP inhibition may also affect the proliferation and colonization of triple-negative breast cancer cells, according to our findings with MDA-MB-231 cells from triple-negative breast cancer.

Source link: https://doi.org/10.1007/s12079-021-00649-9


Multi-targeted molecular docking, drug-likeness and ADMET studies of derivatives of few quinoline- and acridine-based FDA-approved drugs for anti-breast cancer activity

These drugs act by various mechanisms of action; for example, neratinib works on epidermal growth factor receptor 1 and human epidermal receptor type 2 enzymes, whereas amsacrine and pyrazoloacridine act on topoisomerase II enzymes. The findings revealed that neratinib had a stronger binding affinity toward EGFR and HER2, but had a lower affinity towards topoisomerase II and topoisomerase II. As previously demonstrated experimentally, amsacrine and pyrazoloacridine were shown to have better binding scores in topoisomerase II and topoisomerase II and topoisomerase II and topoisomerase II instead of EGFR and HER2, as well as EGFR and HER2. The results reveal that the engineered quinoline- and acridine-based drugs derivatives may be investigated as a potent breast cancer inhibitory drug with their improved multi-targeted inhibition capability and reactivity. Developed derivatives may be used in vitro and in vivo studies to show their therapeutic value in breast cancer therapy.

Source link: https://doi.org/10.1007/s11224-022-01878-3


Including partners in discussions of sexual side effects from breast cancer: a qualitative study of survivors, partners, and providers

There are some differences in two leading sets of clinical studies regarding the inclusion of survivors' romantic partners in clinical trials regarding this topic among survivors and their service providers. In a secondary analysis of a larger qualitative survey, we examined breast cancer survivors, partner, and oncology provider perspectives on including partners in discussions about cancer-related sexual side effects. Methods Partnered female breast cancer survivors completed online surveys, and close relatives of breast cancer survivors and breast cancer survivors conducted semi-structured interviews. Conclusions Partners were infrequently included in discussions about cancer-related sexual side effects, even though survivors, partners, and providers alike expressed interest in these conversations that took place with the couple together — when that is the survivor's choice. Many breast cancer patients are concerned about including partners in clinical discussions about sexual issues.

Source link: https://doi.org/10.1007/s00520-022-06917-7


Impact on fatigue of different types of physical exercise during adjuvant chemotherapy and radiotherapy in breast cancer: systematic review and meta-analysis

Background Physical fitness in women with breast cancer has shown benefits in lowering exhaust levels during adjuvant radiotherapy and chemotherapy. Objective Assess the effect of various types of physical workouts on fatigue, as well as the most efficient in reducing this adverse effect during adjuvant breast cancer treatment. Methods The inclusion criteria were random controlled clinical trials of physical fitness in women with breast cancer from stage I to IV, over 18 years, assessing exhaustation using validated questionnaires. According to our review of subgroups, the supervised combination of resistance training with aerobic training is the most efficient physical workout to reduce fatigue. Women with breast cancer in the intervention groups showed a significant reduction in fatigue only during chemotherapy, according to the researchers.

Source link: https://doi.org/10.1007/s00520-022-06809-w


The mediating effect of pleasure and menopausal symptoms on sexual activity among young breast cancer survivors

Purpose: Young breast cancer survivors often go through a dramatic change in menopause as a result of cancer treatment and suffer from sudden symptoms. This research investigated the differences in the frequency of sexual activity between young breast cancer survivors and young healthy women. Methods The Fallowfield's Sexual Activity Questionnaire and the Menopausal Rating Scale both completed a sociodemographic survey, resulting in the deaths of 97 young breast cancer survivors and 75 young healthy women. In addition, the breast cancer survivors completed a medical information questionnaire. Conclusions and implications These findings show how pleasure can influence young breast cancer survivors' sexual behaviour and their relationship to menopausal symptoms. Despite their early and induced menopause syndromes, these young women should be provided with the right information and interventions that could enable them to have more pleasure in sexual activities.

Source link: https://doi.org/10.1007/s00520-022-06923-9


Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway

We show that various CaSR mutants, mainly breast cancer patients, differ in their ability to stimulate Rac, a small Rho GTPase traced to cytoskeletal reorganisation and cell protrusion, but that the mitogenic ERK pathway is also involved. We used invasive MDA-MB-231 breast cancer cells to see how CaSR promotes Rac and promotes cell migration.

Source link: https://doi.org/10.1007/s12079-021-00662-y


Reproductive Considerations for Patients with Early-Onset Breast Cancer

Purpose of Study Early-onset breast cancer is associated with a variety of problems in reproductive health. Recent Results Many breast cancer treatments, such as chemotherapy and endocrine therapy, can be gonadotoxic or teratogenic, according to New Results. Multiple fertility preservation options are now available to young breast cancer patients, including embryo and oocyte preservation, ovarian tissue preservation, and ovarian suppression with GnRH agonists. Summary Fertility conservation and other reproductive services are on the rise and are providing a great deal to the early-onset breast cancer community.

Source link: https://doi.org/10.1007/s12609-022-00445-3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions