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Breast Cancer - Europe PMC

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Last Updated: 10 May 2022

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Development of an immune-related prognostic biomarker for triple-negative breast cancer.

Patients and Methods: We extracted complete transcriptome from breast cancer tissue of 30 TNBC patients and then used bioinformatics techniques to determine the differences in tumor tissue and paracancerous tissue. In the microenvironment surrounding tumor tissue and para-cancerous tissue, we use two metrics to highlight the main differences in immune infiltration. The Immune Infiltration Score was calculated using two measurements that indicate the degree of increased and decreased infiltration in each sample's sample, which culminated in the creation of the Immune Infiltration Score. To test the IIS, the Taiwan we compared tumor-infiltrating immune cell contents and immune infiltrating status in TNBC samples with CIBERSORT and ESTIMATE score to validate the IIS. Conclusion: we investigated the immune infiltration landscape in 30 TNBC patients and developed IIS as a novel and reliable biomarker to measure the TNBC patients' progression-free survival and prognosis.

Source link: https://europepmc.org/article/MED/35481432


Evidence of rotator cuff disease after breast cancer treatment: scapular kinematics of post-mastectomy and post-reconstruction breast cancer survivors.

Background Breast cancer survivors may be at risk of developing rotator cuff disease after therapy. During an overhead reach task, the aim was to determine scapular kinematics in breast cancer survivors with and without impingement pain. The presence of impenet pain in breast cancer survivorship groups was also categorized by the presence of impingement pain. Conclusions There are kinematic differences in breast cancer survivors that may be contributing to future rotator cuff disease development.

Source link: https://europepmc.org/article/MED/35441571


Epigenetic drugs induce the potency of classic chemotherapy, suppress post-treatment re-growth of breast cancer, but preserve the wound healing ability of stem cells.

The cytotoxicity of classic paclitaxel chemotherapy on triple negative breast cancer is demonstrated both alone and in combination with epigenetic agents is explored by our research. The effects of paclitaxel's use in and without epigenetic therapy on the post-treatment success and wound healing potential of adipose stem cells are illustrated by the following table. Moreover, after the drugs' removal with no effect on ASCs wound healing ability, the combination of paclitaxel and epigenetic treatments results in cancer toxicity that is harmless to TNBC cells. The use of epigenetic agents in lieu of standard chemotherapy is cytotoxic to TNBC cells and prevents post-treatment recovery of TNBC, while maintaining ASC wound healing ability.

Source link: https://europepmc.org/article/MED/35389825


Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity.

Breast cancer is common and diverse, with notably high incidence and mortality rates. In this research, we developed a pH-sensitive tumor self-targeting DDS based on self-assembled HFn loaded with Cur, in which Cur was encapsulated into a HFn cavity by using a disassembly/reassembly technique, and transmission electron microscope characterized Cur@HFn. Following intravenous injection, the pharmacokinetics was also tested in tumor-behaving mice. Cur@HFn is pH sensitive and displays sustained drug release under marginally acidic conditions, according to In vitro release studies. Cur@HFn has a greater in vivo therapeutic effect and lower systemic toxicity, according to our report. The findings of the present study showed that the Cur@HFn has been safely delivered and has potential use in breast cancer diagnosis.

Source link: https://europepmc.org/article/MED/35363115


Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells.

MTX and STAT3 siRNA were added to MCF7 cells by flow cytometric analysis and confocal laser scanning fluorescence microscopy for use in breast cancer therapy. Both MTX and STAT3 siRNA, which were introduced by chMSNs, have significantly reduced breast cancer cells' viability relative to single treatments alone. In addition, protein corona pastes coated the NPs' outer surface, which made the NPs' outer surface different between the NPs with and without drug potentiation, potentially modulating cell uptake. This report is the first review of chitosan modified MSNs' co-delivery of MTX and STAT3 siRNA.

Source link: https://europepmc.org/article/MED/35132929


A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy.

Chemotherapy is one of the most commonly used ways to diagnose breast cancer clinically. The development of drug delivery systems has gained increasing importance in cancer therapy in order to tackle these drawbacks. Here, a new pH-responsive supramolecular organic framework drug delivery complex loading doxorubicin is produced. In vivo, the anti-tumor function was investigated by evaluating nude mice body mass, tumor number, and weight, as well as a preliminary mechanism analysis carried out by HE and TUNEL staining, but also a preliminary mechanism investigation was conducted by HE and TUNEL staining. Both in vitro and in vivo experiments showed that DOX@SOF could enhance the anti-tumor activity of DOX for MCF-7/ADR tumor cells and tumors. The results showed a new drug delivery strategy and reversing multi-drug resistance in clinical chemotherapy, according to this report, which gives a highly effective strategy to prepare stimulus-responsive supramolecular drug delivery complex for treatment of drug-resistant cancer.

Source link: https://europepmc.org/article/MED/34967270


Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity.

Chromone has emerged as one of the most important synthetic scaffolds for antitumor development, which encourages the production of new candidate drugs with greater effectiveness. A series of nitrogen mustard derivatives of chromone were created and synthesised in this research in order to find promising anti-breast tumor candidates. With IC50 values of 1. 83 and 1. 90 M, respectively, methyl -3--2-propanoate showed the most potent antiproliferative activity, as well as certain selectivity between tumour cells and normal cells, in particular.

Source link: https://europepmc.org/article/MED/34957906


A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy.

Chemotherapy is one of the most commonly used ways to treat breast cancer clinically. The design of drug delivery systems has drew increasing interest in cancer therapy to help resolve these drawbacks. Here is how to make a new pH-responsive supramolecular organic framework drug delivery complex loading doxorubicin. Also a preliminary mechanism analysis was conducted by HE and TUNEL staining, investigating nude mouse body weight, tumor volume, and weight in vivo. Both in vitro and in vivo experiments showed that DOX@SOF would enhance DOX's anti-tumor activity. This review highlights a cost-effective way to prepare a stimulus-responsive supramolecular drug delivery complex for the treatment of drug-resistant cancer, as well as stimulating scientific curiosity in determining new drug delivery techniques and reversing multi-drug resistance for clinical chemotherapy.

Source link: https://europepmc.org/article/MED/34949133


The discovery of a novel series of potential ERRĪ± inverse agonists based on p-nitrobenzenesulfonamide template for triple-negative breast cancer in vivo .

A series of new ERR inverse agonists based on a p-nitrobenzenesulfonamide template were uncovered, and a compound 11 with high potency may be able to block the transcription of ERR-regulated target genes. In addition, compound 11 demonstrated a significant reduction in breast cancer xenograft tumors in vivo. Compound 11 could form hydrogen bonds with Glu331 and Arg372 in addition to its hydrophobic interaction with a ligand-binding domain, according to the docking results.

Source link: https://europepmc.org/article/MED/34894977


Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer.

Comparing to staurosporine, Novel halogenated phenoxychalcones 2a-f and their corresponding N acetylpyrazoline 3a-f were synthed and tested for their anticancer activity against breast cancer cell line and the normal breast cell line. Also, chalcone 2f demonstrated significant cytotoxic activity with IC 50 = 1. 87 M and selectivity index = 11. 03. Both total mitogen activated protein kinase and phosphorylated enzyme were reduced in MCF-7 cells, demonstrating its ability to reduce cell proliferation and survival. Chemical 2c and 2f were shown to interact with p38alpha MAPK active sites in docking studies.

Source link: https://europepmc.org/article/MED/34894967

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions