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Breast Cancer - DOAJ

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Last Updated: 10 May 2022

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A rapid rise in hormone receptor-positive and HER2-positive breast cancer subtypes in Southern Thai women: A population-based study in Songkhla.

Breast cancer incidence in low- and middle-income countries, including Thailand, is on the rise. We also estimated the breast cancer incidence and trends based on the hormone receptor and human epidermal growth factor receptor 2 status. The Songkhla Cancer Registry's cross-sectional analysis included 2,883 women diagnosed with primary invasive breast cancer from 2009 to 2018. The 5-year age cohorts' incidence rate and the age-standardized incidence rate were estimated. HR+/HER2- had the highest ASR in breast cancer, according to the study. According to the ASR of HR+/HER2-, the ASR of HR+/HER2-2 will reach 30. 0 and 29. 2 cases per 100,000 women, while ASR of the HR+/HER2+ would reach 8. 8 and 10. 4 cases per 100,000 women in 2030. The rising trends of HR-positive and a part of the HER2-positive breast cancer diagnosis and delivery of facilities are showing the increasing popularity of the future health care budgeting, resource allocation, and facility delivery.

Source link: https://doi.org/10.1371/journal.pone.0265417


CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells.

Targeting estrogen receptors by determining the transcriptional coactivators required for estrogen receptor synthesis is a viable alternative to the same limitations as affecting estrogen receptors specifically. We show that the CREBBP/EP300 acetyltransferase inhibition potently inhibits breast cancer cell line model growth in vitro and in vivo and is in a manner that is not directly targeting ER.

Source link: https://doi.org/10.1371/journal.pone.0262378


Evaluation of Mg, Cu, Zn, Cr and Mn Concentrations in Iraqi patients’ female with Breast Cancer.

In both breast cancer patients and healthy control women, there has been a significant rise in the concentration of, but not so much decrease in Cu concentration in comparison to the healthy control group.

Source link: https://doaj.org/article/81de5f9d5e414d5cbf01b13e934650ae


Determination of Integrinα2 (ITGA2), Progesterone, Prolactin, Estradiol, Zinc and Vitamin C in Serum of Female Iraqi Patients with Breast Cancer

Breast cancer is one of the most common mortality causes in women from Western Countries, in Iraq, breast cancer is the second cause of death after cardiovascular Diseases. Patients' age rang years who attended to at a medical city educational oncology hospital and Al-Waatani hospital in Baghdad, were divided into two groups; the second group, which was evidently healthy for females who were not a control group, was divided into two groups. Conclusion: According to the strong correlation between the three research variables, increasing levels of progesterone and decreasing level of vitamin c may have an effect on integrin expression in a downregulated manner, with breast cancer occurring and prognosis.

Source link: https://doi.org/10.30526/2017.IHSCICONF.1773


Sera Level and Polymorphism of Interleukin-33 Gene in Iraqi Females Patients with Breast Cancer

In comparison to 34 relatively healthy women who were matched with patients as a comparison, blood samples were obtained from 66 Iraqi patient women diagnosed with breast cancer, which were divided into two groups: pre-treatment [PT] and under chemotherapy [UTC] patients. AG genotype was more prevalent in control than in patients [76. 47, 58. 46] in comparison to other genotypes AA, GG, with no significant difference between the fisher's exact probability according to the fisher's exact probability. There was no correlation between breast cancer development and IL-33 SNP [rs1929992]. In comparison to the GG genotype, which had the highest prevalence in the patients' population, Allele G had an environmental fraction, while allele A had preventive fraction, which related to rise in the level of IL-33 in the healthy control group, with both genotypes AA, AG.

Source link: https://doi.org/10.30526/34.1.2806


Gene Expression of MicroRNA-370 in Some Iraqi Women with Breast Cancer

Breast cancer has risen to a high incidence of breast cancer in Iraq, particularly in the last years. In Iraqi cancer patients, the micro RNA-370 molecules have not been identified. The aim of this research was to identify micro RNA-370 molecules in breast cancer patients as an early detection biomarker of breast cancer patients and determine its relationship with breast cancer patients' clinicopathological characteristics. In comparison to ten standard tissue samples collected as a control group, fifty fresh tissue samples were obtained from benign and malignant breast patients in addition to ten normal tissue samples collected as a control group. The quantitative real-time reaction measured the miR-370 gene expression level. The upregulation of miR-370 gene expression in benign lesions and breast cancer tissue may be used as a biomarker for early breast cancer detection.

Source link: https://doi.org/10.30526/2021.IHICPAS.2652


Evaluation of Ceruloplasmin Oxidase Activity in Sera of Breast Cancer Individuals in Kurdistan Region/ Iraq

The aim of this investigation was to determine ceruloplasmin oxidase production, specific enzyme, iron content in sera of patients with breast cancer and comparing with a healthy group, as well as the possibility of using enzyme as a tumor marker for breast cancer. The results showed that there was a significant rise in ceruloplasmin activity among breast cancer patients relative to the control group, although total protein level for breast cancer patients increased by a large increase in ceruloplasmin activity, serum total iron concentration, and specific activity of ceruloplasmin strongly elevated in breast cancer patients relative to the control group, although total protein level remained unchanged unchanged, although total protein level displayed no significant change relative to the control group.

Source link: https://doi.org/10.30526/2021.IHICPAS.2653


Consumption of Food Components of the Mediterranean Diet Decreases the Risk of Breast Cancer in the Makkah Region, Saudi Arabia: A Case-Control Study

BackgroundBreast cancer is one of the most common causes of death worldwide, affecting both men and women. Breast cancer has been the most common form of cancer in women in Saudi Arabia for the past few years. Dietary habits and cultural beliefs vary by region, and further research is required to show the connection between these diet habits and cultural beliefs, which can influence breast cancer risk. This study was conducted in Makkah, Saudi Arabia, and it investigated the connection between preventive dietary factors of the Mediterranean diet and breast cancer incidences among postmenopausal women. MethodsA case-control study was conducted in King Abdulla Medical City Hospital, Makkah, Saudi Arabia, and included 432 Saudi female participants: 218 in the control group and 214 breast cancer patients.

Source link: https://doi.org/10.3389/fnut.2022.863029


Contrast-Enhanced Spectral Mammography-Based Prediction of Non-Sentinel Lymph Node Metastasis and Axillary Tumor Burden in Patients With Breast Cancer

Until 2012 and 2021, a total of 1–2 positive sentinel lymph node metastasis and axillary tumor burden among breast cancer patients with 1–2 positive sentinel lymph nodes and contrast-enhanced spectrogram analysis were included. The AUC values of the developed radiomics nomogram are 0. 82 in the experimental group and 0. 77 in the temporal validation cohort, providing useful data for predicting breast cancer incidence and axillary tumor burden in breast cancer patients. Radiomics can demonstrate lymph node metastasis and improve predictive results, and radiomics can show how CESM images can help identify lymph node metastasis and increase predictive results.

Source link: https://doi.org/10.3389/fonc.2022.823897


ST08 Altered NF-κB Pathway in Breast Cancer Cells In Vitro as Revealed by miRNA-mRNA Analysis and Enhanced the Effect of Cisplatin on Tumour Reduction in EAC Mouse Model

In MDA-MB-231, triple-negative breast cancer cells were reported earlier, triple-negative breast cancer cells were the product of a novel curcumin derivative with anti-apoptotic and anti-migratory activity. ST08 is a novel curcumin derivative with apoptotic and anti-migratory activity in a novel curcumin derivative that showed apoptotic and anti-migratory activity in triple-negative breast cancer cells. The effects of cisplatin in vitro and in vivo in mouse EAC breast cancer models with minimal risk are not known. By parallel analysis of miRNA and mRNA, ST08 induced changes in gene expression were investigated. Cell proliferation induced by ST08 therapy was reduced by this therapy, but no additional cell cytotoxicity was observed when using IKK-16, indicating ST08 control of the NF-B pathway in MDA-MB-231 cells.

Source link: https://doi.org/10.3389/fonc.2022.835027

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions