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Breast Cancer - DOAJ

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Last Updated: 10 November 2022

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The application of exosomes in the treatment of triple-negative breast cancer

A heterogeneous and invasive breast cancer subtype is estrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor receptor 2 -negative. They originate from various types of donor cells and produce a complex mix of nucleic acid types and proteins; after binding to recipient cells, the exosomes release their contents that perform their biological functions. In addition, the related risks and future directions of using exosomes for TNBC therapy will be addressed.

Source link: https://doi.org/10.3389/fmolb.2022.1022725


Effectiveness of nursing interventions on the sexual quality of life of patients with breast cancer: A systematic review and meta-analysis.

Background: Although many studies have shown the benefits of nursing interventions on the sexual quality of life of breast cancer patients, the results have not been synthesised. This report seeks to determine the impact of nursing interventions on patients with breast cancer's sexual quality of life. Included were studies evaluating the effects of nursing interventions on sexual quality of life. Nursing interventions significantly improved sexual quality of life, including sexual function and sexual satisfaction, according to meta-analysis results. Nursing interventions had a statistically significant short-term effect on sexual appetite and a significant effect in older patients. Conclusions Nursing intervention may be a cost-effective way to improve the sexual quality of life of breast cancer survivors. Nursing interventions had a dramatic short-term effect on sexual development, and older patients had a dramatic rise in sexual satisfaction.

Source link: https://doi.org/10.1371/journal.pone.0277221


Computational multiplex panel reduction to maximize information retention in breast cancer tissue microarrays.

As such, choosing which markers to include on a panel is critical, because losing vital markers will result in a lack of biologically relevant data, but finding redundant markers will give you a lot of space for other markers. Here we discuss several panel selection methods and evaluate them based on their ability to reconstruct full panel images and data within breast cancer tissue microarray datasets using cyclic immunofluorescence as a proof of concept. With a Spearman correlation of 0. 90 with the reduced panel, the correlation-based selection techniques produced the best single-cell marker mean intensity predictions with the best single-cell marker mean intensity estimates. With the few number of markers that are specific measurement metrics and architecture biases in mind, researchers can produce more effective multiplex imaging panels that maximize the amount of information retained with the limited number of markers used here.

Source link: https://doi.org/10.1371/journal.pcbi.1010505


Cohort profile: Risk and risk factors for female breast cancer after treatment for childhood and adolescent cancer: an internationally pooled cohort

Purpose: The International Consortium for Pooled Malignancies After Childhood and Adolescent Cancer was established in 2018 in order to address knowledge of breast cancer risk and risk factors related to childhood/adolescent cancer by pooling individual patient data from seven cohorts. Both an invasive and in situ diagnosis are in place at the same time, 835 females developed their first subsequent breast cancer, including 635 invasive breast cancer only, 184 carcinomas in situ only, and 16 with both an invasive and in situ diagnosis at the same time. Plans for Children and Adolescent Cancer Survivor studies were 2. 2% and 6. 2%, respectively, for elucidating other knowledge gaps on subsequent breast cancer risk and the danger of future malignancies.

Source link: https://doi.org/10.1136/bmjopen-2022-065910


Serum amino acids quantification by plasmonic colloidosome-coupled MALDI-TOF MS for triple-negative breast cancer diagnosis

High incidence, metastasis, and recurrence have been identified in triple-negative breast cancer. TNBC patients' survival is greatly dependent on the early diagnosis and early diagnosis. The dried sample spot from colloidosomes can aid in MALDI-TOF MS analysis of small molecule metabolites with high sensitivity, high reproducibility, and excellent quantification results. The amounts in free amino acids in TNBC patients were significantly lower than those of heathy controls, and the concentrations were also significantly different from those of breast lump patients. We've developed a machine learning-based classification system to distinguish TNBC patients from the controls, including healthy controls and breast lump patients, and 97%, respectively, based on the quantities of serum free amino acids.

Source link: https://doi.org/10.1016/j.mtbio.2022.100486


Ficus crocata leaf extracts decrease the proliferation and invasiveness of breast cancer cells

Due to its more invasive capacity and non-responsiveness to hormone therapy, triple-negative breast cancer is the most aggressive breast cancer subtype. Many species of the Ficus genus have been used as an alternative to conventional medicine against malignant diseases. Breast cancer cells MCF-7 and MDA-MB-231 were tested for the following reasons: The aim of the study was to determine the effect of hexane, dichloromethane, and acetone extracts from F. crocata on the proliferative and invasive capacity of breast cancer cells MCF-7 and MDA-MB-231. Hisx-EFc, Dic-EFc, and Ace-EFc demonstrated cytotoxic activity on MDA-MB-231 tumor cells and, to a lesser degree, on MCF-7 cells, without presenting cytotoxic activity in MCF-10A non-tumor cells. Conclusions: Dic-EFc and Ace-EFc at low doses reduced breast cancer cell proliferation and invasiveness, mainly of MDA-MB-231 cells. The above supports the potential use of chemicals from leaf extracts of F. crocata in neoadjuvant therapy to reduce breast cancer tumor formation, mainly triple-negative tumors.

Source link: https://doi.org/10.1016/j.heliyon.2022.e11405


Women’s preference to apply shared decision-making in breast cancer screening: a discrete choice experiment

Objectives Underwent A discrete choice experiment was conducted with 12 questions to determine the relative importance of each attribute of shared decision-making and their willingness to pay for more inclusive care in breast cancer screening programs. Results According to WTP, one of the most significant characteristics of the study was u2018Who makes the decision U202 uses conditional mixed-effect logit regression and stratification for BCSP. According to the resulting report, women aged 50 to 60 were surveyed between June and November 2021 in Catalonia, Spain. According to WTP, the only valid attribute was gender-matched logit regression and stratification. In addition, 53. 3 percent of the women had a WTP of u20ac10 or more for SDM. Women's preferences regarding attributes did not influence their WTP, according to Women's Choices In BCSP, participants' beliefs regarding attributes did not influence their WTP and instead preferred either SDM or informed decision-making.

Source link: https://doi.org/10.1136/bmjopen-2022-064488


Community collaboration to improve access and outcomes in breast cancer reconstruction: protocol for a mixed-methods qualitative research study

Introduction After mastectomy, breast reconstruction plays a significant part. The lower incidence of breast reconstruction in non-white women and women of lower socioeconomic status may reveal a complicated interplay between patient and physician factors and access to care. paraphrasedoutput:Methods and analysis Methods and statistics It's unclear what community-specific barriers are influencing breast reconstruction's acceptance. Methods and analysis is a mixed-methods research that incorporates qualitative patient interviews with quantitative practice patterns to produce an actionable plan to fix breast reconstruction in the local community.

Source link: https://doi.org/10.1136/bmjopen-2022-064121


Impact of the COVID-19 Pandemic on Cancer Staging: An Analysis of Patients With Breast Cancer From a Community Practice in Brazil

paraphrasedoutput:METHODSWe reviewed the effects of the COVID-19 pandemic on breast cancer diagnosis in this study. METHODSWe extracted data from the medical records of patients aged 18 years or older than 18 years who were diagnosed with BC and began treatment or follow-up in private oncology clinics in Brazil between 2018 and 2021. RESULTS Early BC was categorized as stage I-III and advanced disease as stage IV, with 6,493 patients in the pandemic and 5,260 patients in the prepandemic period. During the COVID-19 pandemic epidemic in Brazil, an increase in the number of cases of advanced-stage BC in the country. CONCLUSION : During the COVID-19 pandemic period, a significant rise in the number of cases of advanced stage at diagnosis was reported in Brazil.

Source link: https://doi.org/10.1200/GO.22.00289


Effect of breast cancer education based on the health belief model on knowledge, health belief, and breast self-examination among female students of Debre Markos University, Northwest Ethiopia, in 2021

BackgroundBreast cancer is the most common cause of mortality in female patients around the world, and the second most common cancer after lung cancer in both sexes. The growth, maintenance, and change of health behavior are all linked to the formation, maintenance, and change of health habits; education, attitudes, and encouragement are all important individual determinants of health behavior change. The study was conducted on 210 samples from simple random sampling; therefore, the purpose of this study is to determine the effect of health belief model-based breast cancer education on knowledge, health attitude, and breast self-examination among female students of Debre Markos University, Ethiopia, in 2021. MethodsA quasi-experimental study was conducted; samples were divided into an intervention group and a control group based on their cluster. Implementing a health belief model-based educational intervention about breast cancer at various stages of life is crucial to combat the disease, according to the study's findings.

Source link: https://doi.org/10.3389/fonc.2022.1034183

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions