Brain Tumor - U.S. Department of Veterans Affairs

Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts.

"We previously reported that non-ablative radiation enhanced the delivery of anti-MGMT oligonucleotides in subcutaneous tumor xenografts, which reduced MGMT levels. " We investigate this strategy to raise CRT efficiency in rod brain tumor xenograft models by examining this method. In the NSCLC brain metastasis model, there was a similar trend observed. To assess the effectiveness, AMONs concurrent with CRT reduced tumor volumes in the medulloblastoma model, which was also found in the NSCLC brain metastasis model. To lower MGMT levels and improve CRT effectiveness, we provide evidence of concept for the use of non-ablative radiation to guide and enhance the introduction of morpholino oligonucleotides into brain tumor xenograft models.

Source link: https://doi.org/10.1038/s41417-021-00324-6

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