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Brain Tumor - PubAg

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Last Updated: 15 October 2021

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The potential of metformin as an antineoplastic in brain tumors: A systematic review

Brain lumps are testing to take care of and trigger serious death and morbidity. This research analyzes current studies on the results of metformin in primary brain tumor patients via organized testimonials. We selected medical studies comparing the restorative outcomes of brain tumor therapy with and without metformin. The professional benefits of the medicine were assessed with the overall survival and progression-free survival of brain tumor patients. Those studies showed that the combination of metformin with temozolomide provided post-radiotherapy resulted in better OS and PFS.

Source link: https://pubag.nal.usda.gov/catalog/7341555


Characterization of Immune Cell Subsets of Tumor Infiltrating Lymphocytes in Brain Metastases

The diversification of tumor infiltrating lymphocytes is not well identified in brain metastasis. To resolve this, we executed a targeted evaluation of immune-cell subsets in brain metastasis cells to test immunosuppressive routes included in brain metastasis. Phenotyping these TILs we found lumps with reduced TILs had substantially higher expression of the immune-checkpoint molecule VISTA in tumor cells as well as in their microenvironment. Low TILs-tumors presented CD8+ T-cells that co-express VISTA substantially more compared to high TILs group, where CD8+cells significantly co-express IBA-11.

Source link: https://pubag.nal.usda.gov/catalog/7387176


Managing children with brain tumors during the COVID-19 era: Don’t stop the care!

The COVID-19 pandemic has considerably stressed health care systems worldwide, subsequently lowering cancer cells care solutions and delaying treatments. Pediatric populations infected by COVID-19 have shown mild clinical symptoms contrasted to adults, perhaps due to decreased sensitivity. A punctual diagnostic workup might reduce children's suffering and protect against loss of self-confidence in the health care system amongst moms and dads.

Source link: https://pubag.nal.usda.gov/catalog/7234842


PSMA-targeted nanoparticles for specific penetration of blood-brain tumor barrier and combined therapy of brain metastases

Breast cancer brain metastases represent a major reason for morbidity and death among patients with breast cancer. A-NPs-cT selectively target PSMA on BTB for particular BTB crossing and specially bind with p32 for BCBM targeting. We divulged the effective synergism of doxorubicin and lapatinib for BCBM combined therapy. A-NPs-cT displayed boosted uptake than integrin-targeting RGD-modified NPs in BTB endothelial cells and showed about 4. 57-fold more powerful infiltration via the BCBM-associated BTB as compared to the typical BBB.

Source link: https://pubag.nal.usda.gov/catalog/7149299


Metabolic heterogeneity and adaptability in brain tumors

The metabolic intricacy and adaptability generally observed in brain growths, especially glioblastoma, is essential for their advancement and development. In this evaluation, we will discuss metabolic variety in brain cancer and highlight the role of cancer cells stem cells in controling metabolic heterogeneity. We will also highlight potential therapeutic modalities targeting metabolic susceptabilities and take a look at just how intercellular metabolic signaling can shape the tumor microenvironment.

Source link: https://pubag.nal.usda.gov/catalog/7179973


Rapid estimation of tumor cell percentage in brain tissue biopsy samples using inline cartridge extraction mass spectrometry

Tumor cell percent is an essential quality of biopsy samples that straight affects the level of sensitivity of molecular screening in medical practice. In link with this, right here we demonstrate the opportunity of making use of non-imaging ambient mass spectrometry to assess TCP in glial tumor tissues with a high level of confidence. Molecular accounts of histologically annotated human glioblastoma tissue samples were acquired using the inline cartridge removal ambient mass spectrometry strategy. XGBoost regressors were educated to assess tumor cell percent. This outcome demonstrates that ambient mass spectrometry provides an exact technique todetermine TCP in dissected tissues even without implementing mass spectrometry imaging.

Source link: https://pubag.nal.usda.gov/catalog/7338745


Single high-dose vitamin D3 injection and clinical outcomes in brain tumor resection: A randomized, controlled clinical trial

We evaluated the effect of vitamin D3 shot on vitamin D standing and clinical outcomes in patients with low serum levels of 25-hydroxyvitamin D [25D] going through craniotomy for brain tumor resection. Patients with benign brain growths and serum 25D levels ≤ 20 ng/mL were randomized to 2 teams with an equivalent number of topics. The control team was left without intervention, and both groups undertook regular therapies. On day 5 after craniotomy, the product 25D degrees boosted significantly in the study hall. The size of ICU and health center remain was substantially lower in the study hall compared to the control group. With and without the application of logistic regression analysis, there was no substantial difference in perioperative complications. Intramuscular shot of 300,000 IU of vitamin D3 in patients with reduced product degrees of 25D undertaking craniotomy, can climb safely the lotion 25D degree.

Source link: https://pubag.nal.usda.gov/catalog/7224917


Induction of Brain Tumors by the Archetype Strain of Human Neurotropic JCPyV in a Transgenic Mouse Model

JC Virus, a participant of the Polyomaviridiæ family, is a human neurotropic infection with world-wide distribution. Mad-1 the pressure associated with PML includes two 98 base pair repeats, whereas the archetype strain, which is the transmissible form of JCPyV, consists of just one 98 tandem with two insertions of 62 and 23 base sets specifically. The oncogenicity of JCPyV has been suspected since direct vaccination into the brain of rodents and primates resulted in the growth of brain lumps and has been credited to the viral protein, T-Antigen. These transgenic pets established tumors of neural crest origin, including: primitive neuroectodermal growths, medulloblastomas, adrenal neuroblastomas, pituitary growths, deadly peripheral nerve sheath tumors, and glioblastomas. Neoplastic cells from all various phenotypes express T-Antigen. The close parallels between the growths established by these transgenic animals and human CNS tumors make this animal model a superb device for the study of viral oncogenesis.

Source link: https://pubag.nal.usda.gov/catalog/7294929


Dysregulation of chromatin organization in pediatric and adult brain tumors: oncoepigenomic contributions to tumorigenesis and cancer stem cell properties

We additionally highlight examples that illustrate just how epigenomic changes have the possible to influence 3D genome design in brain lumps. We will propose the principle of "epigenomic disintegration" to discuss the shift from stem-like cells to separated cells in hierarchically organized brain cancers.

Source link: https://pubag.nal.usda.gov/catalog/7337658


The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor

However, once subjected to the blood stream, NPs can quickly adsorb proteins to form the "protein corona," which may significantly prevent the targeting ligand from binding to its receptor. For brain-targeting distribution, nanotherapeutics should go across the blood-- brain barrier to go into the brain parenchyma and then target the diseased cells. Nonetheless, it remains elusive whether, apart from receptor recognition, the healthy protein corona can influence various other procedures involved in BBB transcytosis, such as endocytosis, intracellular trafficking, and exocytosis. The targeting capacity of NPs toward infected cells after transcytosis continues to be vague. Here, transferrin, a brain-targeting ligand, was combined to NPs to review BBB transcytosis and brain tumor targeting ability. The in vitro protein corona abolished the Tf-mediated impacts of the previously mentioned procedures, whereas the in vivo protein corona undermined these effects. After crossing the BBB, Tf preserved its targeting specificity towards brain tumor cells.

Source link: https://pubag.nal.usda.gov/catalog/7376940

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions