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"Aim: Determine delayed diagnosis by prediagnostic symptomatic interval among Filipino pediatric brain tumor patients and determine causal causes. " Methods: From 2015 to 2019, data was collected retrospectively on Philippine General Hospital pediatric brain tumor patients from 2015 to 2019. Conclusion: Delayed diagnosis of brain tumor patients in Filipino brain tumor patients is often related to age, tumor types, and signs that are uncommon in this condition.
Source link: https://europepmc.org/article/MED/35678529
"Introduction Awake Craniotomy is well-known for brain tumor removal in the eloquent zones. " This paper aims to investigate the experiences of patients from an Asian population who underwent awake craniotomy for tumor resection. Methods of collecting Patient Experience Data Patient experience was collected by interviewing patients using a structured questionnaire at a follow-up visit. From medical records, information on patient demographics and diagnosis were obtained. Eighteen patients who underwent 20 awake craniotomies were recruited. Ninety-five percent of families surveyed their family to be in favour of awake craniotomy. Most patients did not experience pain/discomfort or fear during an intraoperative procedure. Nearly all found intraoperative motor and word testing to be straightforward. Eighty percent of patients were able to have awakened craniotomy again if indicated. Conclusion In an Asian population, awake craniotomy is well tolerated. All patients had a positive to excellent overall experience, with the majority of people willing to undergo awake craniotomy again. ".
Source link: https://europepmc.org/article/MED/35678489
In this research, "the cytotoxic activity of a sequence of dinitrosyl iron complexes against cells of various origins has been investigated. " Complexes with thiourea and 1,3-dimethylthiourea were found to cause cell death in several cell lines of both cancerous and non-cancerous origins, as well as cancerous ones, respectively, while the N -ethylthiourea-bearing complex caused cell death in cells derived from brain tumors. [Fe 4 S 3 7 ], [Fe 4 S 3 7 ], [Fe 4 S 3 5 ], [Fe 4 S 3 6 ], and [Fe 4 S 3 6 ], a neological cluster ions containing NO elements, have been found in the solution of the N -ethylthiourea-bearing complex's nephrogenic complex ions, [Fe 4 S 3 ] ], [Fe 4 S 3 5 ] ], ] ], ] ], [Fe 4 S 3 5 ] t ], [Fe 4 S 4 ] t ] -T t n t ] tylthioure, [Fe 4 S 3 4 S 4 S 3 7 ] a -Fe 4 S 3 5 ; [Fe 4 S 3 5 "Black salt" anion formation in a DNIC solution with N '-ethylthiourea was investigated using density functional theory," Roussin's "black salt" anion formation was investigated using density functional theory.
Source link: https://europepmc.org/article/MED/35635550
"Classification of brain tumor in magnetic Resonance Imaging images is extremely common in healthcare planning, early diagnosis, and outcome evaluation. " A new way to classify brain tumors is introduced in this study, using Salp Water Optimization-based Deep Belief network. The input picture is pre-processed to eliminate the artifacts seen in the input picture at the beginning of the process. Using BRATS, 2018 surveys, and sensitivity at 0. 928 for BRATS, 2020 dataset, yielding improved results with highest precision at 0. 933, specificity at 0. 880, and sensitivity at 0. 938.
Source link: https://europepmc.org/article/MED/35667619
"Background Differential diagnosis between medulloblastoma, ependymoma, and astrocytoma is relevant due to differing medical treatment protocols and projected survival. Using a random forest classifier, the aim of this study was to investigate non-invasive MRI-based radiomic analysis of whole tumors in order to determine the histological tumor types of pediatric posterior fossa brain tumors and improve discrimination accuracy. ADC sequence resulted in the top ten contributions according to the wavelet identifier. The random forest classifier conducted 100% accuracy on the training samples and established the highest reliability, 0. 952, 0. 926, and 1. 000 for EP, MB, and PA, respectively, with a 0. 952, 0. 946, and 1. 000 for EP, MB, and PA. "For differentiating pediatric posterior fossa brain tumors, a random forest classifier based on the ADC sequence of the whole tumor provides more quantitative results than TIWI and T2WI in distinguishing pediatric posterior fossa brain tumors. ".
Source link: https://europepmc.org/article/MED/35667473
"Despite the fact that the brain has inherent, specific characteristics of other organs, the connection between brain metastatic NSCLC cells and tumor microenvironment related to tumor formation remains elusive. " Notably, multiple signaling pathways involved in inflammatory responses, nuclear factor kappa-enhancer of activated B cells, and cancer metastasis have been stimulated in BM-NSCLC by contact with two bTME cell types. This novel platform provides a way to define future molecular targets and for safe anti-cancer therapy targeting the crosstalk between metastatic cancer cells and adjacent parts of bTME.
Source link: https://europepmc.org/article/MED/35657027
"Abstract BACKGROUND: Compared to other childhood malignancies, pediatric brain tumors have the highest incidence of delayed diagnosis. " OBJECTIVE: To determine delayed diagnosis based on the prediagnostic symptomatic interval among Filipino pediatric brain tumor patients and determine causal causes, see supporting factors. METHODS: The data was collected retrospectively on pediatric brain tumor patients of Philippine General Hospital from 2015 to 2019. The median time from symptom onset to first physician consultation was 22 days. Prior to brain tumor diagnosis, the majority of people were diagnosed with another disorder. Popular fossa tumors, malignant tumors, and vomiting are among the causes of early brain tumor diagnosis. CONCLUSION: Delayed diagnosis among Filipino brain tumor patients is correlated with age, tumor types, and signs that are not unusual in this condition. This underscores the need for first contact physicians to be aware of these signs and maintain a diagnosis of brain tumor as a distinct. ".
Source link: https://europepmc.org/article/MED/PMC9165355
"Abstract Pediatric brain tumor preclinical field suffered for years from the lack of in vitro and in vivo models for years. " One of the many ways that the Children's Brain Tumor Network's Brain Tumor Network improves pediatric brain tumor research and discovery is through the support of the tumor model design initiative. Cell lines used in basic biology and translational research internationally have been used in over 40 requests for cell lines in recent years. The collected and returned patient clinical data and genomic records are tied to deidentified patient clinical and genomic data and are freely available on Kidu2019's First Data, Cavatica, and PedcBio portals. This open-source repository model is an example of a unique research collaboration that has been supported by patients and their families and designers and has been designed with one aim to bring rapid change to children suffering from brain tumors.
Source link: https://europepmc.org/article/MED/PMC9165219
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