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Brain Tumor - Crossref

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Last Updated: 10 June 2022

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Concentrations of IGF-I and IGFBP-3 and Brain Tumor Risk in the European Prospective Investigation into Cancer and Nutrition

"Abstract Background: Insulin-like growth factor-1 is vital in normal brain development, but IGF-I overexpression in the adult brain may be a risk factor for tumor formation. Methods: We investigated the connection between circulating levels of IGF-I and IGFBP-3 in relation to the risk of gliomas, meningiomas, and acoustic neuromas by using a case-control strategy nested in the European Prospective Investigation into Cancer and Nutrition. After mutual adjustment of these two variables, the risk of low-grade gliomas was raised with elevated IGF-I and decreased with elevated IGFBP-3 concentrations, but these results were non significant after exclusion of the first year of follow-up; this result was non significant. Conclusion: High concentrations of IGF-I may be positively related to the risk of low-grade gliomas and acoustic neuromas, but we are unable to exclude reverse causation, particularly in the case of low-grade gliomas. Factors of the IGF axis may play a role in the etiology of certain forms of brain tumors. ".

Source link: https://doi.org/10.1158/1055-9965.epi-11-0179


Occupational Exposure to Extremely Low-Frequency Magnetic Fields and Brain Tumor Risks in the INTEROCC Study

"Several studies have investigated whether ELF exposure in different time windows of exposure may have correlated with particular histologic types of brain tumors. " In the large-scale INTEROCC research, this study investigates the connection between ELF and brain tumors. Estimates of mean workday ELF exposure based on a work exposure matrix were established. There was no correlation between lifetime cumulative ELF exposure and glioma or meningita risk. However, there were positive correlations between cumulative ELF 1 to 4 years before the diagnosis/reference date and glioma [odds ratio 1. 6; PLinear trend 0. 01, 0. 01, 25th percentile vs. 0. 2; 0. 001]; and, marginally smaller meningioma compared to meningioma [odds ratio — 1. 67; 95% confidence interval 2. 16. 0 Conclusions: In the recent past, there were positive correlations between ELF and glioma, according to the researchers. "Occupational ELF exposure may have a role in the later stages of brain tumorigenesis. ".

Source link: https://doi.org/10.1158/1055-9965.epi-14-0102


Issues of Diagnostic Review in Brain Tumor Studies: From the Brain Tumor Epidemiology Consortium

"Abstract Epidemiologists routinely conduct systematic single pathology studies to minimize interobserver diagnostic variation, but this approach does not support the development of a mixture of studies from geographical regions and institutions where diagnostic policies vary," says Epidemiologists. In the context of protocol needs for consortial studies, a meeting of neuropathologists and epidemiologists focused on brain tumor classification issues. Both types of brain tumors have sufficient general agreement over time, across regions, and among individual pathologists, so one can safely use existing diagnostic results without further investigation: glioblastomas and meningiomas. At least gathering pathology reports, at least establishing the pathology department and classification system used in the diagnosis, are two key characteristics of these tumors that benefit from the collection of pathology data. Epidemiologic research protocols must address the study's objectives, diagnostic advancements that have occurred over time, and other topics unique to the type of tumor being studied. ".

Source link: https://doi.org/10.1158/1055-9965.epi-07-0725


Factors associated with delayed diagnosis among Filipino pediatric brain tumor patients: a retrospective review

"Aim: Determine delayed diagnosis by prediagnostic symptomatic interval among Filipino pediatric brain tumor patients and determine causal causes. " Methods: From 2015 to 2019, data was collected retrospectively on Philippine General Hospital pediatric brain tumor patients. Conclusion: Delayed diagnosis among Filipino brain tumor patients is correlated with age, tumor structure, and signs that are unusual in this condition.

Source link: https://doi.org/10.2217/cns-2022-0009

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions