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Brain Injury - Astrophysics Data System

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Last Updated: 04 August 2022

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Syzygium aromaticum (L.) Merr. & L.M.Perry mitigates iron-mediated oxidative brain injury via in vitro, ex vivo, and in silico approaches

Clove has been identified as a spice rich in phytochemicals that could be exploited in drug manufacturing. In vitro, ex vivo, and in silico studies, the aim of this research is to investigate the neuroprotective effect of S. aromaticum on Fe 2+-mediated oxidative brain damage in Fe 2+ mediated oxidative brain injury. We investigated the in vitro antioxidant capabilities of aqueous S. aromaticum using standard protocols. In rat brain tissue tissue, Oxidative damage was induced by incubating them with FeSO 4 and treating them with different amounts of ASAE. The two leading phytochemicals for AChE were ellagic acid and stigmasterol, with ellagic acid having a greater binding affinity for the BChE enzyme in a molecular docking study. Stigmasterol had also more binding energy than the BACE-1 protein. The evaluation of lead phytochemical complexed to specific proteins in comparison to unbound proteins in 100 ns molecular dynamics revealed a high degree of stability.

Source link: https://ui.adsabs.harvard.edu/abs/2022JMoSt126833675O/abstract


Noninvasively recorded high-gamma signals improve synchrony of force feedback in a novel neurorehabilitation brain-machine interface for brain injury

Brain injury is the leading cause of long-term disability worldwide, largely due to impaired hand function. Many BMIs target replacement of lost function, but they can also be used in neurorehabilitation by stimulating neural plasticity and functional recovery. We designed the nrBMI to use electroencephalogram results during a hemicraniectomy in people with TBI. We announce the findings of an initial research group of three human beings with TBI, as well as a control group of three skull- and motor-intact volunteers. We found that high-u03b3 control synchronization between neural modulation onset and nrBMI output/haptic feedback aided significantly in timing coordination between neural modulation onset and nrBMI output/haptic feedback. These proof-of-concept findings show that nrBMIs with high blood pressure can be used by people with reduced ability to control force. Improved coordination between neural modulation and force monitoring for high-u03b3 signals could be highly useful in increasing neural circuits' ability to induce plasticity.

Source link: https://ui.adsabs.harvard.edu/abs/2022JNEng..19c6024F/abstract


Longitudinal abnormalities in white matter extracellular free water volume fraction and neuropsychological functioning in patients with traumatic brain injury

Traumatic brain injury is a global public health issue that is associated with persistent neurological abnormalities and long-term disability. Neuroinflammation and neurodegeneration are two endophenotypes that are associated with rises in brain extracellular water content after injury. The aim of this report was to investigate the relationship between a neuroimaging biomarker of extracellular free water content and the clinical characteristics of patients with traumatic brain injury. We produced a summary score for each subject based on changes in whole brain white matter percentages and free water-corrected fractional anisotropy. In the subacute and chronic post-injury period relative to controls, the sum specific anomaly score for VF was significantly higher in TBI patients. These results demonstrate abnormalities in total brain white matter extracellular water fraction in TBI patients with TBI, which are a significant step toward identifying and validating noninvasive biomarkers that map to pathology-driven disability following TBI.

Source link: https://ui.adsabs.harvard.edu/abs/2022arXiv220601080G/abstract


Reproducing traumatic brain injury in vitro with dielectric elastomer actuators

Using a dielectric elastomer actuator cell injury unit, human brain cells are traumatized. The DEAs on the CID are the same membrane as plated human pericytes, putting an abrupt 20% strain on the cell culture and resulting in a reaction similar to traumatic brain injury.

Source link: https://ui.adsabs.harvard.edu/abs/2022SPIE12042E..03R/abstract


Change in structural brain network abnormalities after traumatic brain injury determines post-injury recovery

The course of an individual's recovery after a severe brain injury is variable, with complete recovery in some instances but persistent disability in others. Our goal was to characterize the variability in recovery post-TBI by identifying a putative neuroimaging biomarker of traumatic axonal injury in people with mild TBI. Each individual underwent longitudinal blood testing to characterize blood protein biomarkers of axonal and glial injury, as well as analysis of post-injury recovery in subacute and chronic periods. We estimated the longitudinal change in structural brain network abnormalities by comparing the MRI results of individual patients with 35 controls. We evaluated this proxy measure of TAI with reliable measures of acute intracranial injury estimated from head CT and blood protein biomarkers. Assessing brain network abnormalities may improve patient stratification for monitoring recovery after neurotrauma.

Source link: https://ui.adsabs.harvard.edu/abs/2022arXiv220514663G/abstract


Feasibility of Overground Gait Training Using a Joint-Torque-Assisting Wearable Exoskeletal Robot in Children with Static Brain Injury

Pediatric gait disorders are often chronic and accompanied by various disorders that hinder rehabilitation attempts. We retrospectively examined the possibility of overground robot-assisted gait training with a joint-torque-assistance wearable exoskeletal robot. 17 children with spastic cerebral palsy, cerebellar ataxia, and chronic traumatic brain injury were among those exposed to RAGT sessions in this research. The oxygen rate difference between resting and training was used to determine the intensity of training in randomly selected sessions, while the Quebec User Evaluation of Satisfaction with assistive Technology 2. 0 was done to determine its acceptability. Six out of eight domains had satisfaction ratings more than four out of five stars, with six out of eight domains receiving more than four out of five stars. In conclusion, overground training using a joint-torque-assisting wearable exoskeletal robot showed improvements in gross motor and gait function following the intervention, which culminated intensive gait preparation, and raised satisfaction ratings in children with static brain injury.

Source link: https://ui.adsabs.harvard.edu/abs/2022Senso..22.3870H/abstract


Wideband microwave head imaging system to detect subdural hematoma brain injury

Biomedical engineering holds a prominent position in medical diagnosis and therapy as an academic field. We use an antenna array to shoot a small amount of electromagnetic energy toward the head, but dispersed EM signals are processed to capture the human head inside. Backscattered signals are captured using an antenna, the target is found by digital signal processing, for data processing and image output image processing, and software engineering is used. A collection of blood outside the brain can occur and is referred to as subdural hematoma, which can be life-threatening. Substitural hematoma can be acute or chronic. A serious head injury can cause acute subdural hematoma. A less head injury can result in persistent subclinical hematoma. By using such an optimizer, antenna performance can be increased. To configure antennas, the number of antenna operation is maximized.

Source link: https://ui.adsabs.harvard.edu/abs/2022AIPC.2463b0020N/abstract


Efficacy of electromechanical-assisted gait training on clinical walking function and gait symmetry after brain injury of stroke: a randomized controlled trial

However, many studies are still having trouble determining the difference between electromechanical-assisted gait training and conventional gait preparation. To compare the effectiveness of electromechanical-assisted gait training on clinical walking stability and gait symmetry of stroke patients, compare this to conventional gait training on clinical walking function and gait symmetry. Patients with stroke were randomly assigned to a control group and an experimental group. Both types of gait training were done for 30 minutes a day, five days a week for four weeks. In the subgroup review of stroke duration of 90 days, FAC and clinical walking functions demonstrated greater improvement in the subacute group than in the chronic group. EXOWALK's electromechanically assisted gait training was as safe as conventional gait training with a physiotherapist. While clinical walking performance in the subacute group increased more than in the chronic group, gait asymmetry did not improve for either group after gait training.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.6880N/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions