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"Nondipping blood pressure is common in diabetic patients and is associated with increased cardiovascular events. " However, the causes and mechanisms of nondipping BP in diabetes are still unclear. In diabetic db/db mice fed a regular chow diet ad libitum, we find that food intake and BP were arrhythmic. Imposing a food intake diurnal rhythm by time-restricted feeding stopped db/db mice from developing nondipping BP and effectively restored the already upset BP circadian rhythm in db/db mice. Interestingly, increasing food availability from 8 h to 12 h during the active dark phase in db/db mice resulted in isocaloric feeding and provided extensive coverage of the BP circadian rhythm in db/db mice. We show that TRF helps the BP circadian rhythm in db/db mice by reducing sympathetic activity during the light phase when they are inactive and fasting.
Source link: https://doi.org/10.1073/pnas.2015873118
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