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Bipolar Disorder - Wiley Online Library

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Last Updated: 15 May 2022

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Mixed Cerebrovascular And Alzheimer’s Type Pathology Mimicking Lewy Body Disease And Its Possible Contribution To the Increased Risk of Developing Cognitive Impairment In Elderly Patients with Bipolar Disorder/Schizophrenia

Bipolar disorder, as compared to other common adult psychopharmatic disorders, has been correlated with an elevated risk of experiencing Parkinson's disease, cerebrovascular disease, and dementia in a later life. For schizophrenia, the similar to BD increased risk of developing dementia was also present. When AD was investigated by its signature biomarkers in the cerebrospinal fluid, surpriseably, the most common cause of dementia, Alzheimer's disease, was absent in elderly BD patients with cognitive impairment. These results, combined, point to an elevated risk of dementia in elderly patients with BD. Overall, the severity of the respective Alzheimer's type pathology in D1 brain could be described as mild to moderate depending on its clinical situation. Some blood vessels in the vessel wall and lumen showed amyloid deposits, which is indicative of amyloid angiopathy. The AD pathology in the hippocampus was also present in the form of NFTs and GVD, and was accompanied by mild neuronal dysfunction in the hippocampus and cortex, according to D2 brain. i AD could be present in elderly BD/SCZ patients and may progress to a clinical stage of cognitive impairment. ii CVD in combination with AD may mimic Lewy Body Disease (LD) and may increase the risk of dementia in older BD/SCZ patients. iiiiiiiia A proper diagnosis of dementia in elderly patients with mixed CVD/AD pathology in BD/SCZ would be helpful in their proper treatment and care.

Source link: https://onlinelibrary.wiley.com/doi/10.1096/fasebj.2022.36.S1.0R425

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions