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Bipolar Disorder - Springer Nature

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Last Updated: 15 May 2022

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Attentional Processing of Threat in Bipolar Disorder: Going Beyond Mood-Congruency

A complex attention span in bipolar disorder does not only pertain to happy or sad biases, but it also leads to troubling facts. An emotional dot-probe task in which an emotional face is simultaneously displayed with a neutral face is applied to BD people in their various episodes: mania, depression, and euthymia were all displayed with a neutral face in their respective episodes: mania, anxiety, and euthymia, as well as a group of healthy controls. Symptomatic BD patients had an attentional orienting bias toward threatening faces, but not for happy or sad faces, though euthymic BD patients did not display any attentional bias for emotional stimuli.

Source link: https://doi.org/10.1007/s10862-021-09905-z


Suicidal Ideation in Bipolar Disorder: The Relation with Clinical and Sociodemographic Variables

Introduction Bipolar disorder is the most common cause of suicide among all mental disorders. Hence, finding causes relating to suicidal ideation is crucial for a more accurate assessment of suicide risk in BD. In BD patients, the relationship between suicidal ideation and clinical and sociodemographic variables is unclear. The presence and severity of suicidal ideation were determined using the Beck Scale for Suicidal Ideation. The insight level and previous suicide attempts provided the lowest AIC score and the highest cross-validity, the severity of depressive and manic signs, and previous suicide attempts, although a lack of motivation and educational background did not contribute to the study's lack of detail. Conclusions According to our findings, more frequent depression and mania symptoms, a higher degree of understanding, and a history of suicide suggest the occurrence of suicidal ideation in BD.

Source link: https://doi.org/10.1007/s11126-021-09965-0


Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

Bipolar disorder is a common health disorder characterized by rapid mood states of mania and depression, which can be difficult to distinguish. DAO-G131V gene expression in human cells resulted in decreased DAO protein abundance and enzyme enzymatic activity, which was Heterologous. Results of cerebellar tissue DNA analysis revealed that Dao G130V resulted in reduced expression of two gene networks that are optimized for synaptic functions and genes expressed, respectively in Purkinje neurons and granule neurons, respectively. In the cerebellum of patients with bipolar disorder compared to healthy controls, these gene networks were also down-regulated, and patients with bipolar disorder risk were also more enriched for additional rare variants. These results show that NMDAR signaling and gene expression in cerebellar neurons in bipolar disorder pathophysiology could be affected by this dysregulation, as well as insights into the structure of the organism.

Source link: https://doi.org/10.1038/s41380-022-01609-4


Downregulation of long non-coding RNAs in patients with bipolar disorder

Bipolar disorder's unusual function is now a candidate in the pathophysiology of bipolar disorder. We compared expression levels of lincRNA-p21, lincRNA-ROR, and lincRNA-PINT in the peripheral blood mononuclear cells from BD patients and healthy individuals in this study. Only in male BD patients compared to male healthy controls was found down-regulation of these lncRNAs in sex-based studies. Also, in BD patients, all three lncRNAs showed a strong pairwise positive correlation in expression level, as well as a significant pairwise positive correlation in gene level. The ROC curve review revealed that lncRNA-ROR could be used as a diagnostic biomarker for distinguishing between BD patients and controls.

Source link: https://doi.org/10.1038/s41598-022-11674-y


Obstetric outcomes regarding the use of lithium in pregnant women with bipolar disorders: a prospective cohort study

Lithium is the mood stabilizer of choice for the avoidance of bipolar relapse over the perinatal period. This research aims to compare obstetric outcomes in women with bipolar disorders on lithium therapy during pregnancy. From January 2005 to March 2017, we enrolled a group of pregnant women with BD who were receiving medical attention at a Tertiary Hospital's Perpetual Mental Health Unit. During pregnancy, 53 percent used lithium, while 47 did not. Despite this, newborns of lithium-treated women had lower Apgar scores at 1 minute and 5 min. Except for an effect on newborn Apgar scores, our results do not reveal any worse obstetric outcomes in women with a BD history taking lithium during pregnancy. Lithium may be an appropriate treatment for pregnant women with BD, particularly those with a high recurrence risk, and always after an individual risk–benefit analysis.

Source link: https://doi.org/10.1007/s00737-022-01234-8


Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype

Bipolar disorders are distinguished by recurrences of depressive and manic episodes. Animal models of bipolar disorder are also available because the disease's cyclicity is impossible to imitate, and it is therefore necessary to investigate mania and depression models separately. Bipolar states in humans differ among bipolar states in terms of mood and emotional preferences. We intend to investigate behavioral correlates of mouse mice's intrinsically appetitive and aversive olfactory and gustatory cues as proxies for the assigned emotional valence. Consequently, the GBR 12909 model of mania may not be suitable for investigating psychological disturbances associated with mania states.

Source link: https://doi.org/10.1038/s41598-022-10965-8


A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers

Both disorders' main symptoms, with depressive signs as the main signs. In a study cohort of 57 participants, we found 646 variants differentially edited between depressed patients and healthy volunteers. We found a combination of six biomarkers that allowed us to distinguish bipolar disorder with a AUC of 0. 935 and high specificity and sensitivity in a second step by choosing from the depressed patients with unipolar depression or BD. Among depressed patients, those suffering from BD, and the use of artificial intelligence enabled the development of a new tool to determine, among depressed patients, those suffering from BD.

Source link: https://doi.org/10.1038/s41398-022-01938-6


Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder

Bipolar disorder is a severe psychological disorder characterized by bouts of anxiety and mania. To investigate the molecular mechanisms behind bipolar disorder's pathophysiology, we conducted transcriptome experiments using RNA-seq data from people with BPD and matched controls, as well as cell culture and animal model studies to investigate the pathophysiology of bipolar disorder. Down-regulated co-expression module was also enriched for genes involved in mTOR signaling and in mTOR-related pathways, as well as enriched with neuronal markers, which was also enriched with neuronal markers. To determine whether the expression of modules related to the mTOR signaling pathway could be differentially restricted in various cell types, we conducted comparative network analyses in experimental models. In various cell types in BPD's PFC, co-expression networks related to mTOR signalling pathways may be up- or down-regulated.

Source link: https://doi.org/10.1038/s41398-022-01944-8


Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia

Since SLC35B2 was previously identified as a molecule that facilitates the release of D-serine, a co-agonist of the N-methyl-aspartate type glutamate receptor, the altered function of SLC35B2 may be related to BD and schizophrenia. We performed genetic association studies of the SLC35B2 gene in Japanese cohorts with 366 BD cases and 370 controls, as well as 2012 SCZ cases and 2170 controls. We then investigated the expression of SLC35B2 mRNA in postmortem brains by QPCR using a Caucasian cohort with 33 BD and 34 SCZ cases and 34 controls, as well as in situ hybridization using a Caucasian cohort with 37 SCZ and 29 controls. We found strong correlations between three SNPs and BD, as well as a significantly reduced SLC35B2 mRNA expression in BD's postmortem dorsolateral prefrontal cortex. In addition, we found normalized SLC35B2 mRNA expression in BD subgroups that were treated with lithium.

Source link: https://doi.org/10.1007/s00702-022-02503-7


Ganglion cell complex thickness changes in patients with different states of bipolar disorder

Objectives neuroimaging studies in patients with bipolar disorder have found that a neuropathological therapy may be helpful in this disorder. Methods The study included a total of 150 patients with bipolar disorder, which were divided into three groups and compared to 50 healthy controls. Results Ganglion cell complex thicknesses were thicker in all quadrants of patient groups than the control group, but the differences were significant in perceptive superior and perceptive inferior quadrants. Conclusions The evaluation of ganglion cell complex thickness by spectral-domain optical coherence tomography can help identify neurodegenerative changes in patients with bipolar disorder.

Source link: https://doi.org/10.1038/s41433-021-01580-4

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions