Advanced searches left 3/3

Bipolar Disorder - PubMed

Summarized by Plex Scholar
Last Updated: 15 May 2022

* If you want to update the article please login/register

Retinal changes in bipolar disorder as an endophenotype candidate: Comparison of OCT-detected retinal changes in patients, siblings, and healthy controls.

OCT findings in patients with bipolar disorder have been published in recent studies. In this research, we wanted to investigate the retinal changes in BD patients and their healthy siblings by comparing them with the healthy control group and investigating these findings as potential endophenotype candidates. Our findings indicate that optical layer analysis with OCT may be a helpful way to detect neuronal changes in BD and GCL+IPL may be a useful endophenotype candidate.

Source link: https://doi.org/10.1016/j.psychres.2022.114606


Effect of Probiotic Supplements on Oxidative Stress Biomarkers in First-Episode Bipolar Disorder Patients: A Randomized, Placebo-Controlled Trial.

Background: No research has looked at the effects of probiotic therapy on anxiety, depression, and mania, as well as their relationships with oxidative stress in patients with bipolar disorder. This research is designed to determine the effects of probiotic supplementation on plasma oxidative stress-related biomarkers and various domains of clinical disease in patients with BPD. However, six other oxidative stress biomarkers raised in BPD patients following the two types of therapies. In addition, a positive correlation between LPC and YMRS scale changes was discovered in BPD patients, although the BPD group was not involved in the probiotic group. Conclusion: The changes in plasma biomarkers of oxidative stress in patients with BPD have the ability to be trait-like markers and serve as prognostic indicators for bipolar patients. In a manic episode, the treatment may have been a promising adjunctive therapeutic approach for BPD patients.

Source link: https://doi.org/10.3389/fphar.2022.829815


Mixed Cerebrovascular And Alzheimer's Type Pathology Mimicking Lewy Body Disease And Its Possible Contribution To the Increased Risk of Developing Cognitive Impairment In Elderly Patients with Bipolar Disorder/Schizophrenia.

For schizophrenia, the similar to BD increased risk of developing dementia was also present. When AD was investigated by its signature biomarkers in the cerebrospinal fluid, surprise, the most common cause of dementia, Alzheimer's disease, was absent in elderly BD patients with cognitive impairment. These results, however, point to an elevated risk of dementia in elderly patients with BD.

Source link: https://doi.org/10.1096/fasebj.2022.36.S1.0R425


Neural underpinnings of emotion regulation subgroups in remitted patients with recently diagnosed bipolar disorder.

Bipolar disorder neuroimaging studies generally involve comparing healthy controls with healthy controls, which may mask neurobiological variability within the disorder. This research aims to investigate the neural underpinnings of proposed BD subgroups of prospective BD patients based on functional involvement in the emotion regulation network and its connection to illness characteristics and relapse risk. When doing an emotion regulation task, eighty-seven remitted patients with newly diagnosed BD and 66 HC underwent functional magnetic resonance imaging. To investigate 'neuronal subgroups' of patients based on their neuronal involvement in a pre-defined emotion control network, a data-driven hierarchical cluster model was used to investigate 'neuronal subgroups' of patients based on their neuronal involvement in a pre-defined emotion regulation network. Patients in subgroup 2 had a history of more and longer mixed episodes. Patients with BD who have either amygdala hyper-activity or broad network hypo-activity during emotion regulation are susceptible to neurobiological heterogeneity among remitted patients with BD. Heightened amygdala reactivity may be a neuronal target for personalized therapies to avoid relapse.

Source link: https://doi.org/10.1016/j.euroneuro.2022.04.010


Familial risk for bipolar I disorder is associated with erythrocyte omega-3 polyunsaturated fatty acid deficits in youth with attention-deficit hyperactivity disorder.

This report looked at the effects of erythrocyte EPA+DHA biostatus in psychostimulant-free ADHD youth with and without a first-degree relative with BD and healthy controls. Compared to HC, erythrocyte EPA+DHA ratio was much lower in HR but not LR, and there was a tendency for HR to be lower than LR compared to LR. ADHD youth with a BD family history have erythrocyte EPA+DHA imbalances and a more invasive medical profile, including more frequent manic and dysregulation signs, as well as ADHD youth without a BD family history.

Source link: https://doi.org/10.1016/j.psychres.2022.114587


Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder.

Bipolar disorder is a frequently severing mental health condition characterized by a shift between extreme mood states of mania and depression. Heterologous expression of DAOG131V in human cells resulted in decreased DAO protein abundance and enzyme enzymatic activity, which was accompanied by reduced DAO protein abundance and enzymatic activity. DAO protein levels in hindbrain regions, as well as increased stress tolerance and blunted behavioral responses to pharmacological inhibition of N-methyl-D-aspartate receptors, were found in a knock-in mouse model of DAOG131, DaoG130V/+. Patients with bipolar disorder in comparison to healthy controls were also down-regulated in the cerebellum of patients with bipolar disorder, and more rare variants of bipolar disorder risk were included in these gene networks. These results show a potential for impairment of NMDAR signaling and gene expression in cerebellar neurons in bipolar disorder pathophysiology and provide insight into the condition's genetic architecture.

Source link: https://doi.org/10.1038/s41380-022-01609-4


Association between CACNA1C gene rs100737 polymorphism and glutamatergic neurometabolites in bipolar disorder.

Abnormalities in Ca2+ homeostasis in Bipolar Disorders have been attributed to glutamatergic receptors and voltage-gated calcium channels. In both BD and HC samples, this research sought to investigate the relationship of the CACNA1C genotype and ACC glutamatergic metabolites measured by 1H-MRS. A total of 194 patients and 73 healthy controls were genotyped for CACNA1C rs1006737, while a 3-Tesla 1H-MRS imaging examination and ACC glutamatergic metabolite were determined. In AA carriers in BD, we discovered overall increased glutamatergic metabolites. In particular, higher Glx/Cr was found in subjects with the AA genotype in comparison to both AG and GG in the overall sample. In addition, female individuals in the BD group with AA genotype were found to have higher Glx/Cr than those with other genotypes. CACNA1C AA carriers in the use of anticonvulsant drugs had higher estimated Glutamine than those of the other genotypes.

Source link: https://doi.org/10.1016/j.euroneuro.2022.04.001


Downregulation of long non-coding RNAs in patients with bipolar disorder.

In this research, we compared expression levels of lincRNA-p21, lincRNA-ROR, and lincRNA-PINT in the peripheral blood mononuclear cells from BD patients and healthy individuals. In patients with BD, expression levels of lincRNA-p21, lincRNA-ROR, and lincRNA-PINT were significantly reduced in patients with BD relative to controls. These lncRNAs were downregulated only in male BD patients compared to male healthy controls in sex-based studies. In addition, the three lncRNAs in BD patients showed a strong pairwise positive correlation in expression level, as well as a significant pairwise positive correlation in expression level. lncRNA-ROR's analysis revealed that it could be used as a diagnostic biomarker for distinguishing between BD patients and controls.

Source link: https://doi.org/10.1038/s41598-022-11674-y


Shared Psychotic Disorder Associated With Bipolar Disorder in the Primary Case in the Context of Opioid Misuse.

Bipolar disorder is a common mood disorder linked to a high prevalence of co-occurring drug use disorders. Shared psychotic disorder is a rare medical condition, and only in a handful of cases of people with BD has been documented. The primary case had a BD diagnosis and no history of psychotic episodes before the current episode, while the secondary case had a diagnosis of posttraumatic stress disorder. SPD cases involving patients with BD are extremely rare. This case report confirms that SPD is a medical condition that can occur not only in situations involving an individual with delusional disorder or schizophrenia, but also when the primary case has a diagnosis of BD.

Source link: https://doi.org/10.1097/PRA.0000000000000628

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions