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Bipolar Disorder - Europe PMC

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Last Updated: 15 May 2022

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Alterations in white matter network dynamics in patients with schizophrenia and bipolar disorder.

White matter network abnormalities in patients with schizophrenia and bipolar disorder are consistent, according to emerging evidence, but the changes in the white matter network in patients with SZ and BD are largely unknown. Patients with SZ and BD are characterized by a selective impairment of brain network controllability, possibly leading to reduced brain state transfer capacity, and new recommendations for mental illness diagnosis and treatment are included in our research.

Source link: https://europepmc.org/article/MED/35567336


Impact of nurse-led medication adherence therapy on bipolar affective disorder: A randomized controlled trial.

Purpose This study evaluated the effect of nurse-led medication adherence therapy on medication adherence behavior and symptoms in patients with bipolar disorder. Method Two arms, single-blind, placebo controlled trial on people with bipolar disorder was administered in India's inpatient department of mental health care services. Conclusion MAT enhanced medication adherence behavior, resulting in a marked decrease in symptoms among bipolar disorder patients.

Source link: https://europepmc.org/article/MED/35561011


Comorbid Eating Disorders in a Sample of Youth With Bipolar Disorder: Elevated Burden of Dimensional and Categorical Psychopathology.

Object: The importance of comorbid eating disorders among bipolar disorder sufferers is gradually understood. Methods: The study included 197 children with DSM-IV BD, aged 13-20 years and recruited from a subspecialized clinic within a tertiary academic health sciences center from 2009 to 2017. Participants in DSM-IV ED and without lifetime DSM-IV ED compared to those without. The BD-I subtype and lifetime lithium use were both significant correlates of no lifetime ED. Female sex, BD-I subtype, cigarette smoking, family history of anxiety, and borderline personality traits were among the most reliable predictors of lifetime ED, according to multivariate analysis. Future studies evaluating specific ED subtypes are recommended, as are treatment studies focusing on comorbid ED in youth with BD.

Source link: https://europepmc.org/article/MED/35552527


Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder.

Bipolar disorder is a commonly severe mental illness characterized by shifts between extreme mood states of mania and depression. DAO G131V gene expression in human cells resulted in reduced DAO protein abundance and enzyme activity, as a result of Heterologous transcription. DAO protein deposition in hindbrain regions, as well as increased stress susceptibility and blunted behavioral responses to pharmacological inhibition of N-methyl-D-aspartate receptors was found in a knock-in mouse model of DAO G131, Dao G130V/+. RNA sequencing of cerebellar tissue revealed that Dao G130V resulted in reduced expression of two gene networks that are enriched for synaptic functions and gene expression, respectively in Purkinje neurons or granule neurons. These gene networks were also down-regulated in the cerebellum of patients with bipolar disorder, compared to healthy controls, and were richer for new rare variants of bipolar disorder risk.

Source link: https://europepmc.org/article/MED/35546635


Socio-economic status and functioning in patients newly diagnosed with bipolar disorder and their unaffected siblings - Results from a cross-sectional clinical study.

Background and Introduction None studies have reported socioeconomic status and functioning in patients newly diagnosed with bipolar disorder and their unaffected siblings. Among patients newly diagnosed with BD, socioeconomic status, job stability, and relationship status were all lower in comparison to HC within educational achievement, occupational attainment, workability, and marriage status compared with HC within educational achievement, employment status, workability, and marital status. According to the Functional Assessment Short Test and Work and Social Adjustment Scale in patients newly diagnosed with BD versus HC, functioning was significantly impaired. Patients had an illness duration of 10. 5 [6. 1; 16. 2] years, even though they were included shortly after a diagnosis of BD, highlighting the challenges of study in illness onset in BD. Patients newly diagnosed with BD, as well as their U. S. counterparts, have lower socioeconomic status and impaired overall functioning as a result of poor overall health.

Source link: https://europepmc.org/article/MED/35561888


Bipolar Disorder and Sexuality: A Preliminary Qualitative Study

Background: Individuals with mental illness are at a higher risk of sexual disorders that affect intimate relationships and quality of life. Changing moods could to a certain degree influence their sexual functioning during manic episodes and with low sexual interest during depressive episodes. The sexual spark in the three female participants was low during depressed episodes, but a more self-destructive way of engaging in sex prevailed. Conclusions: The results indicate that changes in sexual appetite may act as a catalyst or early warning signs of new episodes, as well as early warning signs of new episodes, stressing the clinical importance of treating sexual problems in people with BD.

Source link: https://europepmc.org/article/PPR/PPR491273


Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder.

Background This review looked at all published valproic acid population pharmacokinetic models in adult patients and assessed them for predictive success using external validation methods to determine predictive ability. In our Chinese study, results Models K and L, which were developed in large amounts of Chinese and Thai patients, showed good results. Models H and J demonstrated good results in Tests 2 and 3 of the four experiments, respectively. In previously published models, the most important factors contributing to good results were children, Asian ethnicity, one-compartment designs, and incorporation of body weight and VPA measurements.

Source link: https://europepmc.org/article/MED/35536685


Neural underpinnings of emotion regulation subgroups in remitted patients with recently diagnosed bipolar disorder.

Most bipolar disorder neuroimaging studies involve comparing with healthy controls, which may mask neurobiological variability within the disorder. This report seeks to investigate the neural underpinnings of prospective BD subgroups of a prospective cohort of BD patients based on functional connectivity in the emotion control network and its relationship to illness characteristics and relapse risk. When doing an emotion regulation job, eighty-seven relapsed patients with newly diagnosed BD and 66 HC underwent functional magnetic resonance imaging. A data-driven hierarchical cluster analysis was used to examine 'neuronal subgroups' of patients based on their neuronal function in a pre-defined emotion control network. Hypo-activity was found in all emotion control regions, according to Subgroup 2. Patients in sub-British 2 had a history of more and longer mixed episodes. Among remitted patients with BD, the identified neuronal subgroups of patients with either amygdala hyper-activity or broad network hypo-activity during emotion control differs, which contributes to neurobiological heterogeneity.

Source link: https://europepmc.org/article/MED/35550452


Abnormal patterns of sleep and waking behaviors are accompanied by increased slow gamma power in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity

Using paired video-EEG recordings, we investigated spectral EEG correlates of behaviour seen in Ank3-1b knockout mice during home-cage activity to help understand the effect of defective PV interneurons on network connectivity and behavior in these mice. We anticipated advancements in the quality of EEG signals in the gamma frequency range during human BD conditions, including irregular sleep and activity levels, since PV-interneurons contribute to the emergence of high frequency gamma oscillations. Ank3-1b KO mice had an overall increase in gamma power relative to controls, as well as a decrease in gamma strength relative to seizure phenotype differences in behavior. Compared to non-REM sleep, REM sleep was more common during REM sleep than non-REM sleep. We also found that Ank3-1b KO mice were hyperactive and had a repetitive behavior pattern that was correlated with increased slow gamma strength.

Source link: https://europepmc.org/article/PPR/PPR490288


Quantification of diet quality utilizing the rapid eating assessment for participants-shortened version in bipolar disorder: Implications for prospective depression and cardiometabolic studies.

This study was designed to measure diet quality and evaluate clinical correlates in a bipolar disorder cohort, with the intent of determining bipolar disorder as a multi-system metabolic disorder characterized in part by binge eating habits and atypical depressive symptoms. Participants from the Mayo Clinic Bipolar Disorder Biobank completed the Rapid Eating Assessment for Participants - shortened version to assess diet quality. The average REAP-S score for a U. S. omnivorous diet is 32, with higher scores indicating a healthier diet. The Bipolar Inventory of Symptoms Scale assessed depression. With elevated BMI, waist circumference, disordered eating, and depression, there was a significant inverse relationship between mean REAP-S lower scores with increased BMI, waist circumference, disordered eating, and depression. Conclusions Our findings show that inadequate diet intake in bipolar disorder is correlated with depression, obesity, and cardiometabolic abnormalities. A further delineating potential sex differences in diet intake and depression can help us gain a better understanding of modifiable risk factors for future cardiovascular risk.

Source link: https://europepmc.org/article/MED/35545158

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions