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Bipolar Disorder - DOAJ

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Last Updated: 15 May 2022

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Clinical characteristics, sociodemographic profile, and treatment pattern of bipolar disorder - A multicenter study from India

Bipolar disorder is a chronic debilitating psychiatric disorder that is episodic in nature. The aim of the investigation was to determine the clinicoepidemiological profile of BPD patients and management practices in India, considering the paucity of evidence from an Indian real-world setting. Patients aged 18-to-midgeo patients with BPD type I or II, with a duration of 2 years, were evaluated by using semi-structured questionnaires and standard protocols for socio-demographic profile, clinical findings, and management practices. BPD was diagnosed at a young age of 33. 7 years at the time of diagnosis. Patients on the first episode of BPD, 348 and 226 patients developed mania and depression, according to all. The number of seasonal courses and quick cycling episodes was between 2. 4 and 1. 0, respectively. The duration of BPD symptoms and duration from diagnosis was 11. 9 months and 67. 3 months, respectively, in terms of BPD symptoms and duration from diagnosis. In the majority of the patients, mood stabilizers such as lithium were used.

Source link: https://doi.org/10.1016/j.psycom.2022.100039


Childhood trauma and social cognition in participants with bipolar disorder: The moderating role of attachment✰

Background: Individuals with Bipolar Disorder suffer in Social Cognition, a condition associated with early attachment experiences. Methods: In a sample of 76 adults with BD, we investigated the moderating role of attachment in the connection between childhood traumatic experiences and SC. Using the Experience in Close Relationships questionnaire, early traumatic experiences were analyzed using the Childhood Trauma Questionnaire, SC was tested using the Hinting Task Test, and attachment was investigated. Connections: Attachment anxiety was positively associated with early traumatic experiences and improved SC results, which led to higher scores on attachment anxiety. Attachment anxiety has been demonstrated to be an adaptive tactic among bipolar individuals who have lived through traumatic childhood experiences, according to the findings, attachment anxiety may have been operating as an adaptive tactic. Our findings support the importance of early childhood experiences in the growth of SC in people with BD, as well as some of the disorder's genetic component.

Source link: https://doi.org/10.1016/j.jadr.2022.100359


Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study

This exploratory research sought to find out how tryptophan catabolism in people with bipolar disorder compared to healthy controls, as well as lamotrigine's response to mood stabilizers such as lithium, valproate, or lamotrigine rated with the Lithium Response Phenotype Scale's Retrospective Assessment. The treatment response to valproate and lamotrigine was not related to the tryptophan metabolites, not connected to the tryptophan metabolites. In addition, since quinolinic acid has neurotoxic properties by the glutamatergic pathway, they also strengthen the suggestion that the clinical drug reaction might be related to biochemical processes. The correlation between the lithium response and the measurements of the tryptophan to the kynurenine pathway is of clinical importance and may lead to the selection of the most effective mood-stabilizing drug, which may have advantages toward a personalized medicine approach to bipolar disorder that allows for the selection of the most effective mood stabilizing drug.

Source link: https://doi.org/10.3390/jcm11092517


Directly or Indirectly? The Role of Social Support in the Psychological Pathways Underlying Suicidal Ideation in People with Bipolar Disorder

Perceptive social assistance did not specifically anticipate changes in suicidal conception, but over time, there was a significant indirect mediatory connection between perceived social stability at baseline and shifts in suicidal ideation, via shifts in defeat, entrapment, and hopelessness, which all support the SAMS. Psychological studies that target negative social acceptance early in life, capturement, and hopelessness as time goes, may be a potentially effective way to counter suicidal behavior in people with bipolar disorder.

Source link: https://doi.org/10.3390/ijerph19095286


Increased Asymmetric Perfusion of the Cerebral Cortices and Thalamus Indicates Individuals at Risk for Bipolar Disorder: A Family Cohort Single Photon Emission Computed Tomography Neuroimaging Study

Bipolar disorder is a common medical disorder that affects over 4 million people in North America and over 46 million worldwide. In addition, prolonged untreated or incorrectly treated bipolar disorder may cause brain damage, as shown by the brain. Brain perfusion single photon emission computed tomography neuroimaging provides visual evidence of brain function. A family cohort with bipolar disorder is described and their symptoms are linked to individual SPECT brain scan findings. These results point to two specific patterns of SPECT perfusion scan variations that can be present in patients with bipolar disorder. In addition, these results show that SPECT scan findings may be predictive of individual risk for progressing to symptomatic bipolar disorder. The results in this cohort are preliminary, but the results in this cohort support the need for larger, diverse cohort studies of bipolar and control subjects in order to determine the predictive value of these particular SPECT perfusion findings in bipolar disorder.

Source link: https://doi.org/10.3389/fpsyt.2022.829561


Downregulation of long non-coding RNAs in patients with bipolar disorder

We compared expression profiles of lincRNA-p21, lincRNA-ROR, and lincRNA-PINT in the peripheral blood mononuclear cells from BD patients and healthy individuals in this research. In patients with BD, expression levels of lincRNA-p21, lincRNA-ROR, and lincRNA-PINT were significantly reduced in patients with BD relative to controls. Only in male BD patients compared to male healthy controls was shown down-regulation of these lncRNAs in sex-based studies. Also, in BD patients, the three lncRNAs showed a significant pairwise positive correlation in expression level. lncRNA-ROR can also be used as a diagnostic biomarker for determining between BD patients and controls, according to the ROC curve analysis.

Source link: https://doi.org/10.1038/s41598-022-11674-y


A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers

Abstract Abstracts can be difficult to distinguish Bipolar Disorder from unipolar depression in clinical practice due to the depressive signs, which are the key signs of both disorders. In a research group of 57 participants, we discovered 646 variants differentially edited between depressed patients and healthy volunteers in a first step, using A-to-I RNA editome technology. We selected a series of six biomarkers that allowed a different diagnosis of bipolar disorder with an AUC of 0. 935 and high specificity and sensitivity in a second step by selecting from the depressed patients suffering from unipolar depression or BD. Among depressed patients, those suffering from BD, the association of RNA editing variants modifications with depression subtypes and the use of artificial intelligence enabled the creation of a new way to determine, among depressed patients, those suffering from BD.

Source link: https://doi.org/10.1038/s41398-022-01938-6


Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder

Abstract Bipolar disorder is a serious mental disorder characterized by bouts of depression and mania. We also discovered a down-regulated co-expression module that was enhanced for genes involved in mTOR signaling and in mTOR-related pathways, as well as enriched with neuronal markers. We conducted comparative network analyses in experimental models to determine whether the expression of modules related to mTOR signalling pathway could be differently restricted in various cell types. We wanted to know if the expression of the modules related to the mTOR signaling pathway could be differentiously restricted in different cell types. Both up-regulated modules in the PFC closely correlated with up-regulated module in the brain endothelial cells of mice treated with lipopolysaccharides and mTOR-related pathways such as JAK-STAT, PI3K-Akt, and ribosome were found to be enriched in the common genes, with mice treated with lipopolysaccharides and mTOR-related pathways such as JAK-STAT, PI3K-Akt, mTOR-regulated modules in the PFC correlated with up-moduledothose mTOR gene mTOR mTOR-treated mice treated with lipothelial cells from mice treated with lipothelial cells, metabolic gene expression in the PI3K-Akt, and Akt, thelial cells, ribothelial cells, ribothelial cells, hexothelial cells, ribothelial and PI3K-Akt, Akt, PI3K-Akt, ribothelial cells, ot In different cell types of BPD's PFC, co-expression networks related to mTOR signaling pathways may be up- or down-regulated.

Source link: https://doi.org/10.1038/s41398-022-01944-8


Hsa-miR-19b-3p and Hsa-miR-23b-3P are the candidate biomarkers for bipolar disorder

Bipolar disorder is a chronic psychiatric disorder and one of the leading causes of disability worldwide, with a strong genetic component associated with high heritability. The prognosis for BD patients remains poor despite the lack of reliable biomarkers and pathogenesis and diagnostic procedures, which remain limited. We investigated the gene and miRNA expression characteristics of BD from five expression arrays from the Gene Expression Omnibus database to identify differentially expressed genes and differentially expressed miRNAs between normal and BD samples. The ability of detected miRNAs to distinguish healthy controls from healthy controls was determined by area under the curve using the ROC curve method. In addition, RT-qPCR was used on 50 BD samples and 50 healthy controls to determine the in silico findings. Our findings revealed that hsa-miR-19b-3p and hsa-miR-23b-3P may be potential biomarkers of BD.

Source link: https://doi.org/10.1016/j.imu.2022.100959


Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder.

This study was designed to look at changes in white matter microstructure in patients with psychotic and non-psychotic bipolar disorder. We compared fractional anisotropy and mean diffusion pairwise among the PBD, NPBD, and HC groups using tract-based spatial statistics for diffusion tensor imaging results. In the PBD and NPBD groups, we found several WM areas of reduced FA or elevated MD in comparison to HC. These results indicate that widespread WM microstructural changes may be a common neuroanatomical characteristic of bipolar disorder, whether psychotic or non-psychotic.

Source link: https://doi.org/10.1371/journal.pone.0265671

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions