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BACKGROUND How can hyperuricemia in Chinese patients with bipolar disorder be related to the increasing prevalence of hyperuricemia in bipolar disorder patients was documented. OBJECTIVE The purpose of this research was to determine the prevalence of hyperuricemia in Chinese patients with bipolar disorder. Meta-analysis revealed the prevalence of hyperuricemia in Chinese patients with bipolar disorder. The UA level of male patients with bipolar disorder was 32. 6%, 20. 16%,30. 8 percent, and mixed respectively, which was higher than that in female patients.
Source link: https://doi.org/10.2196/preprints.39557
Bipolar disorder is a medically heterogeneous disorder with a complex underpinning etiopathogenesis that is not well understood. Several large screen proteomics studies have been conducted to provide valuable molecular data without molecular biomarkers being used in the clinical setting. We review the effectiveness of MS proteomics applied to human peripheral fluids to identify BD biomarkers and identify critical pathways of biological pathways here. We searched for studies using MS proteomics to identify proteomic differences between BD patients and healthy controls as a result of PRISMA's PRISMA recommendations. Although MS proteomics has been used to characterize BD, several unknown contributing factors contributed to the findings' heterogeneity.
Source link: https://doi.org/10.3390/ijms23105460
OBJECTIVE The clinical response of patients with bipolar disorder to medical therapy is variable. A better understanding of the neural circuitry involved in bipolar therapy responsivity subtypes could help with diagnosis of a safe surgical target for deep brain stimulation specific to the condition. While subjects in the RSP group had increased connectivity from rostral cingulum bundle to medial orbitofrontal cortex, which is part of the limbic CSTC loop, subjected to increased connectivity in the RSP group, whereas others in the REF group had improved connectivity from rostral cingulum bundle to thalamus. CONCLUSIONS The findings show that bipolar treatment responsivity may be related to significant differences in cingulum bundle connectivity in relation to CSTC loops, which may help identify a surgical target for bipolar disorder treatment using DBS in the future.
Source link: https://doi.org/10.3171/2021.11.jns211833
Hypothesis The description is often indistinguishable in clinical practice from bipolar-I disorder and bipolar-II disorder. This review compared the network of hypomanic signs between patients with BD-II and BD-II. The Network Comparison Test was used to determine the differences in hypomanic symptoms between BD-II and BD-II patients. BD patients were included in a total of 423 patients. The results of NCT revealed that four nodes were significantly different between the BD-I and BD-II samples. In BD-III patients, the two edges were much higher than BD-III patients. Conclusion The hypomanic network is different between BD-II and BD-II patients.
Source link: https://doi.org/10.3389/fpsyt.2022.881414
This study, as well as a case report of a patient who received dental care in the Pontifical Catholic University of Paraná's Special Patient Course, aimed at presenting the key aspects of Bipolar Affective Disorder's literature review, as well as a case report of a patient who received dental care in the Special Patient Course. PUCPR's special patient program recommended that she receive dental care at the special school where she studied and worked. BAD people need additional attention when it comes to behavioral management, as shown by the above.
Source link: https://doi.org/10.21726/rsbo.v12i3.772
Abstract scyophrenia and bipolar disorder are debilitating neuropsychiatric disorders that result from a combination of environmental and genetic causes. Novel open reading frames are genomic loci that give rise to previously unidentified transcripts and protein products. We hypothesize that nORFs are a potentially important group of biological factors that may play a role in SCZ and bipolar disorder pathophysiology. Human accelerated regions are genomic regions that show human-lineage-specific rapid evolution that may be involved in biological regulation and has also been found to correlate with SCZ genes. This research shows that nORFs whose expression is disrupted in SCZ and bipolar disorder are in close proximity to HARs and TEs, and that some of them are highly associated with SCZ and bipolar disorder genomic hotspots. We also show that nORF encoded proteins can form structures and possibly be novel drug targets.
Source link: https://doi.org/10.1038/s41380-021-01405-6
The gabapentinoids, gabapentin, and pregabalin, as well as pregabalin, are intended for the subunits of voltage-gated calcium channels. The results for three of their most common psychiatric uses, bipolar disorder, anxiety, and insomnia, were reviewed and meta-analyzed by a systematic review and meta-analysis. Fifty-five double-blind randomised controlled trials were discovered, and 15 open-label studies were reported. Four double-blind RCTs reviewing gabapentin were discovered, and no double-blind RCTs investigating pregabalin were identified. Across the anxiety spectrum, there was a consistent but not universal effect in favour of gabapentinoids relative to placebo. Pregabalin and gabapentin were more effective than placebo in reducing preoperative anxiety. We conclude that there is limited evidence proving the effectiveness of gabapentinoids in anxiety states, but there are no findings in bipolar disorder and insomnia, and that these disorders should only be used for these disorders with strong justification.
Source link: https://doi.org/10.1038/s41380-021-01386-6
Abstract Background: Evidence has shown correlations between bipolar disorder and cognitive impairment, dysregulated proinflammatory cytokines, and appetite hormones. Methods This cross-sectional research included young adults aged 18 to 39 years who were diagnosed with type 1 BD in the first or recurrent episode, as well as a group of age-/sex-matched healthy controls. Patients in the multiple-episode BD group did significantly worse in the WCST and had elevated rates of ghrelin, as well as lower CRP values than those in the first-episode BD group, according to a multivariate analysis. Patients with BD had significantly higher TNF- and ghrelin levels compared to the healthy controls. Profiles in proinflammatory hormones and appetite hormones, as well as executive function, varied significantly between patients with first-episode and multiple-episode BDs and controls, which may indicate their potential involvement in the clinical and pathophysiology of type 1 BD.
Source link: https://doi.org/10.1017/s1092852922000761
Instituto de Salud Carlos III (GIS) Instituto de Salud Carlos III, a public health disorder in which manic and depressive episodes are mixed. People with BD are often associated with unhealthy diet. Aims: To determine and compare the CRF and physiological responses of two peak, progressive, and ramped protocols on different ergometers in people with BD. Methods BD: In participants with BD, physiological variables assessed by cardiopulmonary endurance exercise tests were determined. Differences were found in peak systolic blood pressure, peak diastolic blood pressure, and test duration with higher values in C. Both methods of assessment could be used interchangeably, according to the no differences between ergometers when assessing CRF and physiological responses in people with BD. The increased blood pressure response in C compared to T may be due to a lack of familiarity with the ergometer and the physiological causes that determine blood pressure.
Source link: https://doi.org/10.1093/eurjpc/zwac056.210
Abstract Background: Individuals with mental illness have a greater risk of sexual problems impacting intimate relationships and quality of life. During manic episodes and with little sexual involvement during depressive episodes, people with bipolar disorder may have a greater influence on their sexual function. The sexual impulsive motivation in the three female participants was low during depressed episodes, but a more self-destructive way of participating in sex prevailed. However, the participants' personal lives were negatively affected by the shifts in sexual orientation due to mood shifts. Conclusions The results show that changes in sexual drive can lead to or early warning signs of new episodes, as well as early warning signs of new episodes, highlighting the clinical significance of focusing sexual in people with BD.
Source link: https://doi.org/10.21203/rs.3.rs-1615894/v1
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