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Bipolar Disorder - ClinicalTrials.gov

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Last Updated: 15 May 2022

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Bipolar Disorder Measures in Clinical Care

The goal population for this study is 30 patients with bipolar disorder who are currently receiving medical attention in study centers. This pilot controlled effectiveness trial will determine the acceptability and acceptability of the research findings. The intervention patients will be given medical and depressive assessments, while the control patients will be given a measure of depressive symptoms. The research coordinator will continue implementing the depressive symptom control arm testing, which is not part of normal care, will improve usual care. Measurement of Fidelity: A chart review would be used to determine fidelity in both directions based on whether the patient completed the survey, whether the clinician reviewed measure findings, and whether the clinician compared current symptom severity to previous symptom severity. The primary data management system, REDcap, will be the primary data management database. The investigators will also pilot the survey device to collect independent measures of clinical outcomes. Hypotheses: More therapy changes will be seen for patients randomized to MBC with manic and depressive symptom therapy products relative to more standard care. According to an expanded usual care, an exploratory hypothesis is that there will be a greater decrease in symptom severity among those randomized to MBC compared to enhanced normal care. Statistical methods: Primary data analysis is used to determine acceptability and feasibility. As the dependent variable and group randomization status is the explanatory variable, the investigators will perform intent to treat analyses using a negative binomial regression to model total number of treatment changes in the first six months as the dependent variable and group randomization status are the explanatory variable.

Source link: https://clinicaltrials.gov/ct2/show/NCT05300919


The Phenomenology and Neurophysiology of Affective Dysregulation in Children and Adolescents With Bipolar Disorder

Objective: We define Bipolar Spectrum disorders as the propensity to have a manic episode when suffering Bipolar Disorder or Subscription-Induced Bipolar Disorder. This study seeks to identify and track longitudinally developmental, socioeconomic, neurophysiological, and neuroanatomical correlates of pediatric BSD, as well as adolescents with persistent irritability and hyperactivity disorder. BSD Study population includes 11 populations that are included in this study: children and adolescents aged 6-17 years old who have met the BSD Study population's genetic and familial characteristics. b Parents of healthy volunteer children or healthy adults in study are surveyed, c Children between the ages of 3-17 years old with attention deficit hyperactivity disorder (HD), and those with attention deficit hyperactivity disorder (MSD) do not have a mood disorder. This report is an outpatient cross-sectional research that includes descriptive interviews, educational assessments, and functional and functional MRI for healthy volunteer children, children with only ADHD, adults with BD, and parents of healthy volunteer children. BSD-British children with severe mood dysregulation will also be compared to those with severe mood dysregulation, sometimes referred to as a broad phenotype of pediatric BD, according to protocol 02-M-0021 Nottelman, 2001.

Source link: https://clinicaltrials.gov/ct2/show/NCT00006177


Pragmatic Patient-Oriented 12-Month Extension Study of Dialectical Behavior Therapy for Youth With Bipolar Disorder

Following participation in the initial study, compelling concerns have been raised by the investigators, research therapists, and patients/patients about what will happen following their participation in the first study: Which DBT outcomes are maintained over time? Participants who have completed one year of DBT at the Centre for Youth Bipolar Disorder have a unique opportunity to investigate the prevalence, dose, and signs for continuing DBT therapy for people with one year of DBT.

Source link: https://clinicaltrials.gov/ct2/show/NCT04283188


Braining - A Randomized Controlled Study on Moderate-vigorous Aerobic Physical Exercise (PE) as an add-on Treatment in Bipolar Disorder. Effects on Recovery Time and Long-term Prevention From Bipolar Depression

Patients with bipolar disorder and ongoing depression are encouraged to participate in the research during regular visits to the psychiatric clinic. According to standard care, all study participants are medicated with mood stabilizers and receive bipolar depression therapy. For the 12 weeks of the study, participants will be randomly assigned to one of three groups 1 moderate to vigorous PE group training along with psychiatric staff three times per week, increasing and stretching exercises group training together with psychiatric staff three times a week, but no supervised PE or relaxation/stretching was available. Participants wear Actiheart, an activity tracker that continuously records physical activity for 7 days, to determine the level of physical fitness. STUDY PERIOD: During the 12 weeks of analysis, participants fill out an activity questionnaire and health questionnaire every week.

Source link: https://clinicaltrials.gov/ct2/show/NCT05340686


Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders

The aim of this research is to determine whether intermittent theta-burst magnetic stimulation to ventrolateral prefrontal cortex or inferior parietal lobule can help patients with bipolar disorder. The findings from this research will help guide future treatment design and improve emotion control in patients with bipolar disorder. During Phase 1, a cohort of 30 healthy control volunteers will be recruited in order to gather a uniform sample from which to compare patient results. During their performance on two emotion regulation tasks, functional magnetic resonance imaging data will be collected from healthy control subjects. When it comes to implicit and explicit emotion control tasks, the effects of iTBS-TMS on emotion regulation will be investigated.

Source link: https://clinicaltrials.gov/ct2/show/NCT04284267

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions