Bipolar Disorder - Astrophysics Data System

Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder

This research was designed to investigate changes in white matter microstructure in patients with psychotic and non-psychotic bipolar disorder. We compared fractional anisotropy and mean diffusion pairwise among the PBD, NPBD, and HC groups using tract-based spatial data for diffusion tensor imaging results. In both the PBD and NPBD groups, there were several WM regions of reduced FA or increased MD, in comparison to HC. These results indicate that widespread WM microstructural changes may be a common neuroanatomical characteristic of bipolar disorder, regardless of being psychotic or non-psychotic.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1765671L/abstract

Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia

Five key DMN subnodes have been identified, five of which were found to be hypo-connected in probands with psychotic disorders. Gene expression in key pathways, including NMDA potentiation, PKA/immune response signalling, synogenesis, and axon guidance that influenced altered DMN connectivity in psychoses was found by a the above-representation of genes. Multiple putative genes and pathways related to an important biological marker that has been attributed to a psychotic condition have been found in the analysis.

Source link: https://ui.adsabs.harvard.edu/abs/2014PNAS..111E2066M/abstract

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