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To retrospectively assess the effectiveness and outcomes of lamellar keratoplasty treatment of feline corneal sequestrum. With a minimum of three months of follow-up, the medical records of cats diagnosed with FCS treated with lamellar keratoplasty with BioCorneaVetTM between 2018 and 2021 were reviewed. Following-up exams were administered every week for three months, optical coherence tomography examination was performed on select patients at 0, 3, 6, and 12 months post-operatively.
Source link: https://doi.org/10.3390/ani12081016
Human induced pluripotent stem cells can be used to produce a variety of cell types in the human body. Cardiac tissue engineering holds a new promise for both basic and clinical studies. Advanced bioengineered cardiac in vitro models can produce contractile structures that are equally effective in vitro heart microtissues for drug testing and disease modeling, thereby promoting the identification of new cardiovascular disorders.
Source link: https://doi.org/10.3390/bioengineering9040168
Lymphedema is characterized by progressive and chronic tissue swelling and inflammation as a result of local accumulation of interstitial fluid related to lymphatic injury or dysfunction. Lymphocyte bioengineering and regeneration have all emerged as a potential therapeutic treatment for postsurgical lymphedema with improved knowledge of lymphedema's molecular mechanisms and pathophysiology, as well as advances in tissue engineering techniques. This review provides an summary of recent breakthrough lymphatic tissue bioengineering techniques, which may be a promising treatment option for postsurgical lymphedema.
Source link: https://doi.org/10.3390/bioengineering9040162
Although skeletal muscle repair after minor injuries, genetic disorders, or severe injuries may be unable to do so, it may be difficult to do so. Induced pluripotent stem cells can produce myogenic progenitors, but their use in combination with bioengineering techniques to alter their phenotype has not been sufficiently investigated. Human iPSC induction of human iPSCs are compared in two transgenic and non-transgenic strategies. Both the embryonic growth process and the pro-myogenic role of the muscle-resident cells in co-cultures are also detailed, highlighting the potential clinical uses of iPSCs in the skeletal muscle tissue engineering field.
Source link: https://doi.org/10.1038/s41536-022-00216-9
Various modified gene-editing methods have been developed based on classical gene-editing techniques. Base editors can effectively perform base substitutions on target sequences, while prime editors can delete or insert sequences. CRISPR devices targeting mitochondrial genomes and RNA have also been tested and established. Multiple gene-editing techniques based on CRISPR/Cas9 have been developed and applied to genome engineering. Transgene-free plants are also more readily available thanks to improved gene editing techniques. We discuss the advancements made to gene-editing tools in recent years in this article, detailing the capabilities, shortcomings, and applications of these improved gene-editing tools.
Source link: https://doi.org/10.3389/fpls.2022.847169
However, in practice, there are several specifics regarding the manufacturing of a CM product that must meet not only the majority of functional requirements of muscle and fat TE, but also the sensory and nutritional characteristics of a traditional food component, i. e. , the meat it seeks to substitute. Bioengineering's target for CM production must be regarded as a multidisciplinary scientific discipline that incorporates principles from biomedical engineering as well as from food manufacturing, design, and development, i. e. , food engineering. This report, we hope, will give a detailed overview of emerging bioengineering techniques for CM manufacture and will be useful to a variety of key stakeholders, from students new to senior researchers looking for the most recent advancements in the field.
Source link: https://doi.org/10.3390/mi13030402
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