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Peripheral nerve injuries remain a difficult problem in need of better treatment methods. Biomaterial scaffolds have been able to modulate the host response to tissue repair by individualized mechanical, chemical, and conductive cues thanks to recent advancements in tissue engineering and nanotechnology. With the ability to unlock the clinical value of a slew of neurotrophic growth factors that have demonstrated promise in improving regenerative outcomes, targeted, sustained delivery of protein therapeutics has been facilitated by advanced bioengineered strategies that have demonstrated promise in improving regenerative outcomes. As such, further investigation into combiningatory techniques utilizing these technological advancements may lead to a path toward clinically transferable solutions to improve patient care of patients with peripheral nerve injury. This review first discusses the various emerging bioengineering techniques that can be used for the prevention of nerve gap injuries.
Source link: https://europepmc.org/article/MED/36453398
Environmental solid waste bioremediation is a process of addressing contaminated solid waste that requires changing environmental conditions to encourage the growth of a diverse range of microorganisms and the destruction of the target contaminants. Bioengineering on several microbial regimes has accelerated to provide more energy toward solid waste recycling and valorization with the introduction of potential microbial populations towards solid waste valorization utilizing agricultural solid waste, organic food waste, plastic solid waste, and various industrial solid waste. With the emergence of a broad range of potential microbial assemblages, improving solid waste contamination tolerance improvement, and solid waste degradability, it could assist in developing a long-term management program for recycling development. The new literature review describes solid waste remediation valorization using a large variety of microbial assemblages with a special emphasis on bioengineering-based acceleration.
Source link: https://europepmc.org/article/MED/36595166
The de novo hair follicles' generation and growing is the most daring hair replacement strategy to correct alopecia. The discovery that the mesenchymal compartment of hair follicles, the dermal papilla, was the key signaling center and component required for fulfilling this vision of hair follicle engineering, spurred study into the fibroblasts that occupy the DP's. Decades of research into determining the characteristics of DP fibroblasts in vitro and in vivo have resulted in the recognition that hair follicle biology is intricate, and dermal papilla is a mystery. In addition, including keratinocytes in the mix to create hair follicle-like composite structures has been investigated, but it is still a long way from a convenient and inexpensive way to produce human hair follicles in a reasonable time frame for patients.
Source link: https://europepmc.org/article/MED/36562864
Prenylation is a post-translational change that is widely present in primary and secondary metabolism. cyanobactin prenyltransferases from cyanobacteria are often responsible for peptide prenylation. Herein we review the latest research on cyanobactin PTases, focusing on their discovery, biochemistry, and bioengineering, as well as the potential use of them as peptide alkylation biocatalysts to produce peptide therapeutics.
Source link: https://europepmc.org/article/MED/36564250
However, one must produce liver organoids with all the key liver cell types in appropriate amounts and relative 3D locations as found in a native liver to recapitulate the physiological characteristics and architecture of a native liver. We explore the current liver organoid systems, including the design of the liver organoid tissue culture, the roles of growth factors for engineering liver organoids, as well as the latest developments in bioengineering liver organoid disease models and their biomedical applications.
Source link: https://europepmc.org/article/MED/36551002
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