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Bioengineering - Crossref

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Last Updated: 10 January 2023

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Case study of a water bioengineering construction site in Austria. Ecological aspects and application of an environmental life cycle assessment model

Besides chemical effects, soil and water bioengineering has the benefit of also considering ecological ethics and the values of landscape aesthetics. To date, no study of energy flows and the potential negative impact of construction in terms of both energy and greenhouse gas balance has been postponed. In this paper, the impact of a bioengineering construction site's impacts are described by the impact terms global warming potential and cumulative energy demand. The most significant factor, according to the water bioengineering construction site, is the effect of the running machines. Finally, an integral ecological assessment of soil and water bioengineering structures should point out the potential negative effects on the installation of the structures during installation and, in addition, include the investigation of potential positive effects due to the growth of living plants in the use stage.

Source link: https://doi.org/10.1007/s40095-021-00419-8


Modulating endotoxin activity by combinatorial bioengineering of meningococcal lipopolysaccharide

A number of novel LPS mutants were found in both lipid A acylation and phosphorylation by systematic molecular bioengineering of meningococcal LPS through recombination of biosynthetic enzymes and oxidation of LPS enzymes, resulting in a variety of novel LPS mutants with variations in both lipid A acylation and phosphorylation. By deletion of lptA in lipid A, phosphethanolamine removal in lipid A by only marginally lowers activity of hexa-acylated LPS, but this decrease is even more apparent in penta-acylated LPS. Expression of PagL deacylase in a penta-acylated lpL1 mutant raised LPS activity, surprising the general rule that tetra-acylated LPS is less effective than penta-acylated LPS. By simply changing the growth temperature, the LpxP enzyme is temperature sensitive, giving precise control over the proportion of expressed modified hexa- and penta-acylated LPS. These LPS derivatives exhibit a wide range of TLR4 gene expression and differential cytokine induction, and can be exploited for use as vaccine adjuvant or other TLR4-based therapeutics.

Source link: https://doi.org/10.1038/srep36575


Bioengineering of Tobacco Mosaic Virus to Create a Non-Infectious Positive Control for Ebola Diagnostic Assays

Abstract: The 2014 Ebola epidemic is the biggest to date. We created a biomimicry that is non-infectious but stable, with the ability to act as a positive control in Ebola diagnostic assays, in response to this critical need.

Source link: https://doi.org/10.1038/srep23803


A Bioengineering Strategy to Control ADAM10 Activity in Living Cells

A Disintegrin and Metalloprotease 10, also known as ADAM10, is a cell surface protease that is ubiquitously present in mammalian cells, where it damages various membrane proteins involved in numerous physiological functions. Although it has been reported that ADAM10 is a zymogen and the removal of the prodomain results in its activation has been deemed a zymogen, other potential ADAM10 proteolytic function and activation remain unclear. We produced a series of engineered ADAM10 analogs that contained Tobacco Etch Virus protease cleavage site, rendering ADAM10 cleavable by TEV. Our findings revealed a bioengineering strategy for controlling the ADAM10 production in living cells, opening the way toward precise control of ADAM10. Finally, we established that our strategy of controlling ADAM10 increased the production of the neuroprotective soluble ectodomain resulting in the increase in the production of the neuroprotective soluble ectodomain.

Source link: https://doi.org/10.3390/ijms24020917


Bioengineering Progress in Lung Assist Devices

Artificial lung technology is advancing at a rapid pace, raising hopes that it will be able to better meet the needs of those in need of respiratory assistance. If you're looking for a safe and effective artificial lungs, please help with an injured lung, encourage patients to lung transplantation, or completely replace native lung function.

Source link: https://doi.org/10.3390/bioengineering8070089

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions