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"The findings of epidemiological studies on the relationship between diet u03b2-carotene and bone mineral density are still unclear. " Using a Bayesian meta-analysis approach, this study was designed to look at the connection between diet u03b2-carotene and BMD. To synthesize results from individual studies, Bayesian hierarchical random effect models were used to synthesize data from individual studies. BMD loss was reduced as a result of diet u03b2-carotene. BMD loss by decreasing was 0. 99 percent in the case of the dietary decreased risk of BMD. For the general population, bone mineral density was reduced by dietary intakes of u03b2-carotene.
Source link: https://doi.org/10.1007/s40745-020-00257-1
"Nerve tissue repair and regeneration is a slow process that can take a long time and cost a lot of money. " On the polyvinyl alcohol/crocin nanofiber scaffolds in vitro, the aim of this research was to investigate the proliferation of C6 cells and human mesenchymal stem cells precursors bone marrow differentiate into neuronal-like cells. PVA/Gel scaffolds containing crocin in three concentrations were made by the electrospinning process. Results MTT C6 cell culture on the scaffolds revealed that proliferation and metabolic activity on a PVA/Gel scaffold containing crocin 5% were much higher than other concentrations. By MAP -2 expression at the mRNA level and NESTIN and MAP-2 at the protein level, MSC differentiation to nerve-like cells was allowed by MAP -2 expression at the mRNA level and MAP-2 at the protein level. PVA/Gel/Cro 5% and u03b2C, according to the authors' findings, "phel/Cro 5% and u03b2C may result in hBMSC differentiation to neural cells. ".
Source link: https://doi.org/10.1007/s11033-022-07123-8
"Despite the fact that this plant derivative product is being used in several cancer types, the safety of u03b2-carotene against malignant mesothelioma remains uncertain. " Deshalb, the current research seeks to investigate the effect of u03b2-carotene on cell viability, apoptosis, and oxidative stress in mesothelioma cells. For 24, 48, 72, and 96 h, the MTT assay measured cytotoxicity. When compared to control cells, the results showed a dramatic decrease in viable mesothelioma cancer cell numbers following u03b2-carotene therapy in a time- and concentration-dependent manner.
Source link: https://doi.org/10.1007/s00210-022-02214-6
"Background/Objectives" The role of vitamin E in chronic disease risk, particularly in un-supplemented setting, is unclear, and studies are lacking on the physiological processes and pathways involved in health outcomes. " In unsupplemented state, this research intends to investigate the relationship between circulating metabolites and serum u03b1-tocopherol concentrations. Metabolomic investigation of 4,294 male participants was carried out in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study based on pre-supplementation fasting serum. Standard deviations in metabolite concentrations per unit difference in u03b1-tocopherol concentration were calculated as standardized u03b2-coefficients and standard deviations. At the Bonferroni-corrected p value, a total of 252 metabolites were attributed to serum u03b1-tocopherol. Conclusions The large number of metabolites, particularly lipid and amino acid compounds associated with serum u03b1-tocopherol, have been found by a large number of metabolites, including lipid and amino acid compounds, provide insight into vitamin E's human health, including its role in cardiovascular disease and cancer. ".
Source link: https://doi.org/10.1038/s41430-022-01112-7
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