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"We hypothesized that an iron-chelator could restore the lost cardiac integrity associated with an elevated HO-1 level," we hypothesized "since iron releases from heme as a result of HO-1 activity. " We investigated the effects of desferrioxiamine in isolated, ischemic/reperfused rat hearts following long-term treatment with vehicle or high-dose BC in this research. The rats' hearts were removed and exposed to 30 minutes of global ischemia followed by 120 minutes of reperfusion for four weeks, with a total of 150 mg/bw kg daily doses of BC. The results show that DFO therapy alone during REP greatly improved postischemic cardiac function and reduced IS, although HO-1 expression was not significantly raised. Despite an elevated HO-1 level, no cardioprotective effects were found in hearts isolated from BC-treated rats, no cardiovascular risks were reported, and DFO management following ISA resulted in a modest improvement in heart function and IS. ".
Source link: https://europepmc.org/article/MED/35566389
"Epidermal growth factor has numerous important biological functions. " However, the effect of inflammation on intestinal cells or tissues is still unclear. In addition, we investigated the effects of u03b2-carotene on EGF's biological activity, and found that after cells were pretreated with u03b2-carotene, the cellular function, biological function, and nuclear signal of inflammation stimulation were partially restored. In summary, the new study finds that inflammation can inhibit EGF/EGFR-mediated signaling in IEC6 cells, indicating that inflammation negatively regulates EGF/EGFR's biological activity. Moreover, we found that u03b2-carotene not only attenuated lipopolysaccharide-induced inflammation in IEC6 cells but also partially restored EGF cell function in IEC6 cells, giving a solid foundation for investigating EGF and u03b2-carotene's biological functions.
Source link: https://europepmc.org/article/MED/35499499
Based on a meta-analysis of observational studies, "Objective To clarify the relationships between dietary vitamin A and beta-carotene intakes with depression. According to researchers, depression was the relative risk of depression for the highest vs. lowest dietary vitamin A and beta-carotene intake category, as well as the standard mean difference between dietary vitamin A and beta-carotene intake for depression vs. control subjects. Vitamin A intake was inversely linked to depression in the overall multivariable adjusted RR. In addition, the combined SMD showed that the dietary vitamin A intake in depression was also lower than that in control subjects. Depression-related dietary beta-carotene intake in depression was also lower than in control groups, according to the combined SMD. Conclusion Both dietary vitamin A and beta-carotene intake is inversely related to depression, according to our findings.
Source link: https://europepmc.org/article/MED/35548582
"Recent studies have linked the beta-carotene oxygenase 1 gene to lipid metabolism, mainly lowering total cholesterol and raising high-density lipoprotein cholesterol levels. " The hypothesis of this research was that the variant rs6564851 near the BCO1 gene is positively linked to the lipid profile in middle-aged Mexican adults. From the Health Workers Cohort Study, 1441 Mexicans older than 40 years of age were included in this report. Our findings revealed that the men carrying at least 1 T allele had higher serum triglyceride concentrations than GG homozygous. Only in the male group, according to the variant rs6564851 there was a risk associated with the serum triglyceride concentrations. In both sexes, we did not find significant differences in serum total cholesterol, HDL-C, and low-density lipoprotein-cholesterol levels. "Our analysis shows that the variant rs6564851 is positively associated with the triglyceride concentrations in middle-aged Mexican male adults in the HWCS.
Source link: https://europepmc.org/article/MED/35461060
"Lung cancer is one of the most common neoplasms worldwide, with about 2. 2 million new cases and 1. 8 million deaths annually. " A systematic review of published evidence from randomized controlled trials concerning the impact of beta-carotene supplementation on lung cancer risk in patients with no lung cancer before the intervention was carried out to help identify the effectiveness of such interventions. No association was found between the beta-carotene supplementation dose and the severity of lung cancer risk's negative association. Beta-carotene supplementation has no effect on lung cancer risk, according to our results.
Source link: https://europepmc.org/article/MED/35405977
"The role of vitamin E in chronic disease risk is incomplete, especially in un-supplemented region, and data is lacking regarding the physiological functions and pathways involved in its influence on health outcomes. " In unsupplemented state, this study intends to investigate the connection between circulating metabolites and serum u03b1-tocopherol levels. In the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a pre-supplementation fasting serum was used to conduct an analysis of 4,294 male participants. Using multivariable linear regression, estimates were estimated for 1,791 known metabolites measured by ultra-high-performance LC-MS/GC-MS/MS/HPLC-MS/HPLC-MS/U03b1-tocopherol concentrations and HPLC-determinable u03b1-tocopherol concentrations. Standard u03b2-coefficients and standard errors were calculated as standardized u03b2-coefficients and standard errors. Vitamin E's large number of metabolites, particularly lipid and amino acid compounds present with serum u03b1-tocopherol, are among the potential ways by which vitamin E influences human health, including its involvement in cardiovascular disease and cancer.
Source link: https://europepmc.org/article/MED/35322169
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