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Beta Carotene - Crossref

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Last Updated: 08 June 2022

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An alternative pathway to β-carotene formation in plant chromoplasts discovered by map-based cloning of Beta and old-gold color mutations in tomato

"In this study, we investigated the cellular mechanisms that controlled the absorption of carotenoids as secondary metabolites during tomato fruit ripening. " Two mutations in tomato fruit pigmentation were tested: Beta, a single dominant gene that increases u03b2-carotene in the fruit, and old-gold, a reversive mutation that abolishes u03b2-carotene and raises lycopene. B encodes a novel form of lycopene u03b2-cyclase, an enzyme that converts lycopene to u03b2-carotene, according to a Molecular analysis, B encodes a novel form of lycopene u03b2-cyclase, which converts lycopene to u03b2-carotene. Our results show that by the B lycopene cyclase, u03b2-carotene is synthesized de novo during tomato fruit growth. The og phenotype is due to null mutations in the gene B, indicating that og is an allele of B. The cloned B genes can be used in a variety of genetic manipulations aimed at altering pigmentation and raising plant food's nutritional value.

Source link: https://doi.org/10.1073/pnas.190177497


Dietary Supplementation of a Natural Isomer Mixture of Beta-Carotene Inhibits Oxidation of LDL Derived from Patients with Diabetes mellitus

"Background: Accelerated atherosclerosis is common in diabetic patients with diabetes mellitus, which may be attributed to elevated lipid peroxidation. " We compared the oxidation of LDL from diabetic to normoglycemic controls and then followed-up the effects of dietary u03b2-carotene supplementation on LDL oxidation. Methods: In comparison with age- and sex-matched control subjects, twenty patients with long-standing non-insulin-dependent diabetes mellitus were assessed. Vitamin A, E, and carotenoids were also measured in LDL's lipid composition and LDL-associated vitamin A, E, and carotenoids. Conclusions: The susceptibility of LDL oxidation by CuSO4 was up 40% in the patients by 40%, with a 35% shorter lag time required for the start of LDL oxidation. Conclusions: Increased sensitivity to oxidation of LDL obtained from diabetic patients is attributed to poor LDL lipid composition and antioxidant content. ".

Source link: https://doi.org/10.1159/000012821


Randomized Trial of 13- cis Retinoic Acid Compared With Retinyl Palmitate With or Without Beta-Carotene in Oral Premalignancy

"Purpose": "Purpose: A review by the Department of Investigation indicates that retinyl palmitate alone or as many beta-carotene will be more effective and less harmful than low-dose 13-cis retinoic acid in treating oral premalignant lesions and reducing the risk of oral cancer. " BC was banned from entering a randomized trial that showed an adverse effect of BC on lung cancer incidence/mortality. The combined BC plus RP and RP alone arm's clinical response rate was not comparable to that of 13cRA. The pharmacological response rate of RP alone was much lower than that of BC plus RP. There was no correlation between 3-month OPL response and subsequent oral cancer development. Conclusion This large chemoprevention trial did not establish whether RP plus BC or RP alone with low-dose 13cRA in lowering the long-term risk of oral cancer.

Source link: https://doi.org/10.1200/jco.2008.17.1850


Response of oral leukoplakia to beta-carotene.

"Leukoplakia is a leading risk of oral cancer and is classified as a premalignant lesion. " Leukoplakia can often be reversed by Retinoids, particularly 13-cis retinoic acid. Beta-carotene, a naturally occurring, nontoxic carotenoid with biologic capabilities, has been used by doctors in the United Kingdom to treat oral leucoplakia. In leukoplakia, we started a random study of 13-cis retinoic acid versus beta-carotene in 1986. However, 11 of the first 16 eligible patients refused to participate unless they were deemed "guaranteed" beta-carotene, owing to the obvious differences in toxicity between the two products outlined in the consent form. In response, the research design was changed to a phase II beta-carotene study, in which the drug was administered daily for 3 months. Responding patients received another 3 months of therapy. There was no evidence of significant toxicity that necessitated drug discontinuation or dose reduction. Beta-carotene has significant involvement in oral premalignancy, according to these findings.

Source link: https://doi.org/10.1200/jco.1990.8.10.1715


Beta-Carotene Affects the Effects of Heme Oxygenase-1 in Isolated, Ischemic/Reperfused Rat Hearts: Potential Role of the Iron

"We hypothesized that the use of an iron-chelator would restore cardiac stability associated with an elevated HO-1 level as a result of HO-1 activity. " Following long-term therapy with vehicle or high-dose BC, we investigated the effects of desferrioxiamine in isolated, ischemic/reperfused rat hearts. While HO-1 expression was not significantly raised, the results show that DFO alone during REP greatly improved postischemic cardiac function and decreased IS. Despite an elevated HO-1 level, no cardioprotective effects were found in hearts isolated from BC-treated rats, no cardiovascular protection was observed, and DFO management following ISA resulted in a modest improvement in heart function and IS, with no cardiovascular function and IS. Iron may play a role in whether BC has antioxidant or pro-oxidant effects in ISA/REP-injured hearts, according to our findings.

Source link: https://doi.org/10.3390/molecules27093039


Predictors of Sustained Smoking Cessation: A Prospective Analysis of Chronic Smokers From the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study

"Because U. S. smoking rates haven't decreased in the last decade, there has been a renewed need to identify reasons associated with smoking cessation. " We selected a sample of 1379 sustained quitters and 1388 relapsers from participants in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study, a dietary intervention study involving Finnish men aged 50 to 69 years old at baseline. Factors associated with both tobacco use and comorbid conditions can influence an individual's ability to maintain long-term smoking cessation. Understanding the underlying causes of action and potential pathways among these variables can help to improve smoking cessation medications. ".

Source link: https://doi.org/10.2105/ajph.2005.084137


Dose-Responsive Alteration in Hepatic Lipid Peroxidation and Retinol Metabolism with Increasing Dietary beta-Carotene in Iron Deficient Rats

"We investigated the antioxidative role of diet beta-carotene and altered retinol metabolism in iron-deficient rats. " Male Wistar-train rats were divided into six groups and fed a control diet, an iron-defic diet, and iron-deficient diets with four different levels of dietary beta-carotene. The hepatic retinol concentration was raised in iron-deficient rats, while the plasma retinol concentration was reduced. Male Wistar-strain rats were divided into two groups, with one group receiving a beta-carotene diet and the other an iron-deficient diet with beta-carotene. ".

Source link: https://doi.org/10.1024/0300-9831.72.5.321


Relationship Between Soup Consumption, Folate, Beta-Carotene, and Vitamin C Status in a French Adult Population

"In adults who frequently consumed soup and folic acid, beta-carotene, and vitamin E and C status were compared to those who did not or were occasional eaters. " Notably, heavy soup buyers had higher dietary intakes of folates, beta-carotene, vitamin C, and, in men, vitamin E. Soups accounted for 27. 5 percent of total dietary intake of beta-carotene in men and 13% in women. Mean serum vitamin C levels in heavy soup consumers were up but not significantly higher than those who were not aware or non-soup consumers. Red blood cell folate in women was also present in this study. According to the present research, soup intake in promotional campaigns to increase vegetable intake may be necessary in improving vegetable intake, contribute to a balanced diet and a healthy nutritional status, and especially vitamin status in the general population. ".

Source link: https://doi.org/10.1024/0300-9831.73.5.315


Effect of beta-Carotene Supplementation on Plasma and Yolk IgY Levels Induced by NDV Vaccination in Japanese Quail

"The chicks were mainly hatched and were fed diets containing variable amounts of retinoids or beta-carotene. " Vitamin A per kilogram, a tenacious IU vitamin A per kilogram, was consumed in a commercial diet. According to the manufacturer's instructions, the quails were immunized orally with Newcastle disease virus vaccine at 8 weeks of age, according to the manufacturer's instructions. Both Groups A and B showed almost identical antibody responses. Compared to Groups A and B, Groups receiving higher doses of beta-carotene had significantly elevated plasma IgY levels. The findings reveal that elevated doses of beta-carotene have a marginal effect on the adaptive immune response in Japanese quail. ".

Source link: https://doi.org/10.1024/0300-9831.73.4.285


Absorption and Conversion of a Single Oral Dose of beta-Carotene in Corn Oil to Vitamin A in Sprague-Dawley Rats with Low Reserve of Vitamin A

In rats with a vitamin A reserve at the lowest end of adequate status, this research was conducted to determine how much of a single oral dose of beta-carotene in oil is absorbed and how much of it is converted to retinoids. A single oral dose of either corn oil or beta-carotene dissolved in corn oil was given to four Weanling rats raised on a vitamin A-deficient diet for four weeks. According to the studies, a single oral dose of beta-carotene would not be a safe way to boost vitamin A status in rats.

Source link: https://doi.org/10.1024/0300-9831.73.4.267

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions