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Benign Tumors - Wiley Online Library

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Last Updated: 02 July 2022

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Genetic and methylation profiles distinguish benign, malignant and spitzoid melanocytic tumors

We compared Spitz nevi and melanoma, comparing detailed genetic and epigenetic results with reference u2010-based and reference methylome deconvolution in determining difficult spitzoid tumors using sophisticated genetic and epigenetic testing. Spitz nevi and melanoma were found to cluster independently of nevi and melanoma, with a different mutation pattern. Only in melanomas has multiple copy number variations and TERT promoter mutations been found. The methylation in Spitz nevi was comparable to benign nevi, according to benign nevi, although Leucocyte UnMethylation for Purity in Spitz nevi was comparable to melanoma. Spitz tumor cases were determined by methylation arrays, and those who were based on genetic profile or copy number variations showed troubling traits suggesting a malignant neoplasm. Spitz nevi is a distinct melanoma entity distinct from both nevi and melanoma, according to comprehensive sequencing and methylation analysis.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ijc.34187


Lifetime prevalence of malignant and benign tumours in companion dogs: Cross‐sectional analysis of Dog Aging Project baseline survey

We reviewed cross-u2010sectional data from a baseline survey of 27 541 living companion dogs registered in the Dog Aging Project as of December 31, 2020, to determine the lifetime prevalence of malignant and benign tumors, as well as other potentially-related conditions that may be attributed to u2010's dependence. Malignant tumors had a lifetime incidence of benign tumours about twice as long as benign tumors were present. In mixed vs. purebred dogs, there were no statistically significant differences in age-adjusted lifetime prevalence of malignant prevalence ratio = 0. 93 percent [95% confidence interval 0. 82, 1. 07] or benign tumors in age-u2010. According to toy and small dogs, the lifetime prevalence of malignant tumours in dog breeds increased with increasing dog size class; with increasing dog size class, the age-u2010adjusted PRs for medium, standard, large, and giant dogs was 1. 65, 2. 92, 3. 67, and 2. 99, respectively; between toy and small dogs. Ongoing prospective data collection will enable future studies on canine tumour risk factors.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/vco.12839

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions