Advanced searches left 3/3

Becker Muscular Dystrophy - Europe PMC

Summarized by Plex Scholar
Last Updated: 03 August 2022

* If you want to update the article please login/register

MicroRNAs as serum biomarkers in Becker muscular dystrophy.

BMD is characterized by progressive muscle degeneration and proximal muscle weakness, despite a large range of medical conditions. We investigated the serum expression levels of a subset of BMD in a cohort of 29 ambulant people affected by BMD and then further classified based on the degree of changes at muscle biopsy and 11 age-matched healthy controls. In addition, serum miR-133b levels were found to be linked to fibrosis at muscle biopsy and patients' motor functions, providing a valuable prognostic marker for BMD patients. These serum myomirs, according to our results, may be an important tool in terms of clinical trials that can help stratify BMD patients.

Source link: https://europepmc.org/article/MED/35880500


Histological analysis of a Becker muscular dystrophy case, diurnal expression of dystrophin in control mice and decreased expression of dystrophin in Bmal1 knockout mice.

Becker muscular dystrophy is a hereditary disorder characterized by dystrophin deletion that ultimately leads to muscle loss, cardiac hypertrophy, and cardiac arrest; these conditions are similar to those in Duchenne muscular dystrophy. We also analyzed dystrophin expression in tissues obtained from human autopsies and mice. In human autopsy cases, dystrophin expression was lower in the heart with BMD than in the center with non-BMD hypertrophy. Dytrophin expression in control mice's heart and muscle was greater at ZT0 than at ZT12. In heart-specific Bmal1 knockout mice, the dystrophin expression was found to be lower than in control mice. Hence, our analysis revealed that BMD was tightly linked to cardiac hypertrophy and cardiac failure, and cardiac arrest, while dystrophin had a diurnal expression pattern in control mice that was tightly linked to Bmal1.

Source link: https://europepmc.org/article/MED/35876434


303 Providers Assessment of Nutritional Practices for the Duchenne and Becker Muscular Dystrophy Population

OBJECTIVES/GOALS: Nutrition plays a vital role in the management of Duchenne and Becker Muscular Dystrophy, but diet advice is lacking. METHODS/STUDY POPULATION (POPULATION): METHODS/STUDY POPULATION (METHODS): The study was conducted in this qualitative, observational research to gain insight into providers' experiences with nutritional products and to identify barriers and solutions to nutrition education/care/counseling at CDCCs. paraphrasedoutput:RESULTS/ANTICIPATED RESULTS: This paper, according to the authors, will contain novel findings and key findings from providers regarding nutrition education/care/counseling efforts in the multidisciplinary treatment of neuromuscular disease multidisciplinary services.

Source link: https://europepmc.org/article/MED/PMC9209139

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions