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Patients with burn wounds are at a high risk of infectious disease, and infections are the most common cause of death after the first 72 hours of hospitalization. In a large tertiary-care burn intensive care unit, we evaluated carriage with MDR GNB in patients. In 21 patients, MDR GNB were transplanted; the most common bacterial species isolated was Pseudomonas aeruginosa, which was present in 11/29 patients. P. aeruginosa was found in bloodstream infections by two of these patients later. Samples from two patients grew genetically identical C. freundii isolates that were resistant to ceftazidime-avibactam. blaKPC-31 was part of a Tn4401b transposon that was found on two different plasmids in each C. freundii isolate, according to the author of whole-genome sequencing. In summary, MDR GNB colonization is common among burn patients and patient-to-patient transmission of highly resistant GNB occurs.
Source link: https://doi.org/10.1128/aac.00688-22
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