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Interferons that respond to coordinating immune responses have a variety of physiological causes. Yet, whether immunomodulatory bacteria function via IFN pathways to promote immune tolerance remains elusive. Priming tolerogenic T regulatory cells by intestinal dendritic cells is required for priming tolerogenic T regulatory cells by intestinal dendritic cells, according to here. The colonization with B. fragilis leads to a distinct type of IFN gene signature in Tregs during homeostasis and intestinal inflammation, according to single cell RNA sequencing of gut tissue. Moreover, B. fragilis-mediated immunity during experimental colitis was abrogated in IFNAR1-deficient mice.
Source link: https://doi.org/10.1101/2021.10.21.464743
Bacteria living in soil microbial ecosystems are vital to terrestrial ecosystem function, but our knowledge of the fundamental features of their genomes, including GC content and genome size, is far from complete. We found that genomic trait averages were the most similar to pH, which we attribute in large part to the correlation of pH with many environmental variables, particularly soil carbon content. Although soil bacteria tend to be more carbon-limited, smaller genomes with higher GC content may reduce the cost of reproduction in carbon-limited soils. These findings reveal that nutrient preservation in soil bacterial populations also applied to amino acid stoichiometry, in which bacteria in soils with low C:N ratios tended to code for amino acids with lower C:N values.
Source link: https://doi.org/10.1101/2021.11.17.469016
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