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BLUE ORIGIN - PubMed

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Last Updated: 20 April 2022

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Molecular Origin of the Anomalous pH Effect in Blue Proteorhodopsin.

Proteorhodopsin is a light-driven proton pump that can be found in marine bacteria, and thousands of PRs are divided into blue-absorbing PR and green-absorbing PR. Using the unusual pH effect, we previously demonstrated BPR to GPR conversion. When we reduced the pH of a BPR's pH to pH 2 and returned to pH 7, the protein absorbs water. The pentamer and monomer reacts differently in pKa of the Schiff base counterion, resulting in different hues at the same pH.

Source link: https://doi.org/10.1021/acs.jpclett.1c03355


Large Plaque-type Blue Nevus with GNAQ Q209P Mutation, Involving Mammary Gland Tissue: Under-Recognized Mammary Condition as an Origin of Primary Mammary Melanocytic Tumors.

The Plaque-type blue nevus is a rare occurrence of blue nevis, which was first described in 1954. In the cut surfaces of the mastectomy specimen, magnetic resonance imaging was unable to detect diffuse melanin deposition in the mammary gland tissue, but pigmentation in the whole mammary parenchyma was observed. The GNAQ Q209P mutation, which was also identified in all four literature cases of plaque-type blue nevus, but not so often in smuce melanoma and uveal melanoma, was identified in clinical blue nevi and uveal melanoma. Even if the pigmented lesion does not exist on the overlying breast skin, it should be noted that plaque-type blue nevus will grow into the mammary gland tissue. Primary mammary melanocytic tumors can be caused by the mammary glands' condition. The GNAQ Q209P mutation can be a typical genetic variation of widespread blue nevi, including plaque-type blue nevus.

Source link: https://doi.org/10.1097/DAD.0000000000002010


Microsatellite Markers from Peronospora tabacina, the Cause of Blue Mold of Tobacco, Reveal Species Origin, Population Structure, and High Gene Flow.

Peronospora tabacina is an essential parasite that causes blue mold of tobacco in Perpetonospora tabacina. P. tabacina isolates were genotyped using nine microsatellites to determine population structure of individuals from subpopulations of central, southern, and western Europe; the Middle East; Central America; and Australia. Some populations had partially clonal subpopulations, according to evidence of linkage disequilibrium, but that subpopulations from Australia and Mediterranean Europe did not. Continuous gene flow across continents could be explained by continuous gene exchange and/or long-distance dispersal of sporangia via wind currents. This report analyzed the most numerous P. tabacina collections and provided insight into the ances, mutation, and evolutionary history of this obligate biotrophic oomycete.

Source link: https://doi.org/10.1094/PHYTO-03-21-0092-R

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions