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Background: Knowing the host reaction to influenza virus infection will aid in the creation of more accurate diagnoses and therapeutic interventions. In the current study, we used a multivariate modeling technique to characterize and compare transcriptional regulatory networks between these three model systems after infection with the H5N1 subtype's highly pathogenic avian influenza virus. Our results also show that airway epithelial cells play a primary response mechanism in initiating hypercytokinemia, which is thought to contribute to H5N1 viruses' pathogenesis. We also show that we can use a transcriptional regulatory framework from the human cell culture literature to make highly accurate predictions about the behaviour of key components of the innate immune system in tissues from whole organisms. This is the first demonstration of a global regulatory network modeling conserved host responses between in vitro and in vivo models, according to this article.
Source link: https://www.osti.gov/biblio/1626646
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