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In the first five human H7N9 epidemic waves, genetic reassortments with H9N2 were common, according to previous studies. However, our most recent study found that the circulating high pathogenicity H7N9 virus has established a dominant internal gene cassette and has decreased the frequency of reassortment with H9N2 since 2018.
Source link: https://doi.org/10.1007/s11262-022-01928-2
Due to its zoonotic and mutative characteristics, the highly infectious avian influenza H5N1 virus has attracted a lot of attention over the past two decades. Despite Iran's geographic location, the country is particularly vulnerable to the H5 HPAI, and since these birds can be identified as the host of the H5 HPAI, it is also vulnerable to this virus. In this research, the molecular characteristics of the H5N8 strain's hemagglutinin and neuraminidase genes of the Malard county of Tehran province and Markazi province's Meighan wetland of Arak city, Markazi province, were discovered. Despite the fact that the A/Goose/Iran/180/2016 virus was also a H5N8. 4. 4 b virus, its cluster was isolated from the A/Chicken/Iran/162/2016 virus. Also, wild migratory aquatic birds appear to have introduced these H5N8 HPAI strains in Iran, which could have occurred throughout the West Asia/U2013East African flyway.
Source link: https://doi.org/10.1007/s11262-022-01930-8
Multiple avian species and, occasionally, humans have been isolated from H9N2 avian influenza viruses. An H9N2 AIV was serially passaged in mouse lung to investigate the potential molecular basis of cross-species transmission of H9N2 AIVs. H9N2 virus with mouse-adapted H9N2 virus exhibited higher virulence and replicated more effectively in mouse lung and liver, according to the mouse's findings.
Source link: https://doi.org/10.1007/s00705-022-05536-1
Avian influenza is being feared for its pandemic risk and lethal effects on poultry and birds. The avian influenza virus that has evolved into a High pathogenic avian influenza virus in domesticated birds is causing rapid spread and widespread disease in poultries. AVI viruses do not replicate in humans, in general, so passing these viruses to humans directly is a very unusual occurrence. The first human case of transmission of the H5N8 strain from birds to humans has been documented.
Source link: https://doi.org/10.1007/s13337-022-00800-z
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