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Avian Influenza - Europe PMC

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Last Updated: 08 May 2022

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Exploring surface water as a transmission medium of avian influenza viruses - systematic infection studies in mallards.

Mallards, an abundant anseriform migratory wild bird species worldwide, and they are also a vital reservoir for the survival of low pathogenicity avian influenza viruses. Natural habitats may be contaminated by HPAIV infection within wild water bird populations. In three experimental settings, the role of small shallow water bodies as a transmission medium for AIV among mallards is investigated. In groups with access to a small 100 L water pool, there was delayed onset but rapid spread of infection seeded by two mallards inoculated with either LP or HP AIV to eight sentinel mallards was seen. A viral infectivity transfer by infected mallards can be a simple way to spread the virus by infected plumage into water bodies, referred to as "Unloading" of virus infectivity from contaminated plumage into water bodies. Surface water in small shallow water bodies, according to Wesley, may play a vital role in aquatic wildbird AIV infection.

Source link: https://europepmc.org/article/MED/35473641


Generation of an avian influenza DIVA vaccine with a H3-peptide replacement located at HA2 against both highly and low pathogenic H7N9 virus.

A differentiating infected with vaccinated animal vaccine is the most effective method for viral eradication in poultry. Here, according to the latest highly pathogenic H7N9 avian influenza virus strain, rGD4 HALo-MH3 -TX, based on a substituted 12 peptide of H3 virus isolated at HA2. HALo-MH3 -TX in immune chickens, resulting in a similar antibody profile with rGD4 and providing 100% clinical protection and 90 percent waiver protection against a highly pathogenic virus challenge. Moreover, serological DIVA characteristics were tested by a commercially developed competitive inhibition ELISA based on a 3G10 monoclonal antibody, and the findings revealed a high reactivity with chickens vaccinated with H7 subtype strains, but not rGD4-TX. Both high and low pathogenic H7N9 subtype AIV are viable DIVA vaccine candidates against both high and low pathogenic HALo-mH3 -TX.

Source link: https://europepmc.org/article/MED/35286234


Human infection with avian-origin H5N6 influenza a virus after exposure to slaughtered poultry.

After the permanent closing of live chicken markets in China, people were forced to change their eating habits from purchasing live poultry for consumption to buying freshly slaughtered poultry. To prevent viruses from spreading from live poultry to humans. Following infection, rapid genomic evaluation of the H5N6 influenza A virus in Zhejiang Province, southeastern China, revealed that these viral variants were of avian origins and adapting to the human host.

Source link: https://europepmc.org/article/MED/35234570


Emergence, prevalence, and evolution of H5N8 avian influenza viruses in central China, 2020.

We began early warning and active surveillance along swan migration routes in central China after the first detection of H5N8 viruses in deceased swans in Inner Mongolia. The sub-clade b2 viruses most likely originated from poultry in Russia, according to a phylogeographic study. Specifically, whooper swans were discovered to be responsible for the introduction of sub-clade b2 viruses in central China; whooper and tundra swans were found to be involved in the outbreak of virus transmission in the Yellow River Basin and the Yangtze River Basin, respectively;.

Source link: https://europepmc.org/article/MED/34825854


Strategies for enhancing immunity against avian influenza virus in chickens: a review.

Poultry infection with avian influenza viruses is a common source of worry for poultry production and human health. Uncontrolled infection and transmission of AIV in poultry raise the risk of viral replication and reassortment, possibly resulting in the emergence of zoonotic viruses. A targeted strategy to minimize clinical signs and shedding in infected birds by vaccinating poultry is a targeted strategy. Strategies aimed at raising the success of AIV vaccines are multi-pronged and include approaches directed at eliciting immune responses in poultry. In addition to the type of vaccine used, vaccine adjuvants also provide an efficient way to increase AIV vaccine safety; therefore, research into various types of vaccine adjuvants and vaccine adjuvant delivery methods is discussed. New findings on the effects of the chicken GIT microbiome on AIV vaccine safety are reviewed here.

Source link: https://europepmc.org/article/MED/35297706


Estimating Movement Rates Between Eurasian and North American Birds That Are Vectors of Avian Influenza.

Because waterbird movements are difficult to quantify, determining the host-specific danger of Eurasian-origin AI movements into North America is difficult. To obtain bidirectional baseline data of these AI hosts' intercontinental migrations, we estimated relative rates of movements, based on long-term genetic averages of gene flow between Eurasian and North American waterbird populations. Some of these bird species are also important in Alaskans' subsistence diets, raising the possibility of direct bird-to-human exposure to Eurasian-origin AI virus. The top three species posing the greatest dangers for intercontinental AI movement were ducks, greater scaup, mallard, and northern pintail, with their respective human and non-existent AI infections posing nearly identical AI infections in ducks, greater scaup, mallard, and northern pintail.

Source link: https://europepmc.org/article/MED/35510470


Chicken meat taste preferences, perceived risk of human infection with avian influenza virus, and self-reported chicken meat consumption in China.

Due to the superior taste, Chinese customers often prefer live chickens for cooking at home rather than chilled or frozen chicken meat. Despite the fact that the selling of live chickens for consumption was limited by the Chinese government after the avian influenza virus epidemic in 2013, people are still buying live chickens. In China, the aim of this research was to investigate the relationships between chicken meat flavor preferences, perceived risk of human infection with AI virus, and chicken meat consumption habits. The findings revealed that Chinese consumers still buy live chickens at a high rate due to taste preferences, and that there are a very low risk of infection with AI viruses. However, the real threat of human infection with AI viruses had no influence on the relationship between the apparent importance of chicken taste and the purchase of live chickens for consumption. However, steps should be taken to reduce customer perception of taste differences between chilled chicken meat and chickens that have recently killed chickens, which could speed this process.

Source link: https://europepmc.org/article/MED/35500380


Assessing Potential Pathogenicity of Novel Highly Pathogenic Avian Influenza (H5N6) Viruses Isolated from Mongolian Wild Duck Feces Using a Mouse Model.

Several new novel avian influenza A viruses were identified in Mongolia in 2020, some of which contained host-specific markers associated with mammalian infection. We also compared their antigenicity with previous H5 Clade 2. 3. 4. 4 human isolates by cross-hemagglutination inhibition. In addition, our experiments revealed that their isolates are less virulent in mice than the previously reported H5 human isolates. However, their antigenicity is distinct from other HPAIVs H5 clade 2. 3. 4. 4, facilitating their continuing evaluation as disease risks are identified and the production of novel candidate vaccines for their neutralization.

Source link: https://europepmc.org/article/MED/35451353


Highly Pathogenic Avian Influenza A(H5Nx) Virus of Clade 2.3.4.4b Emerging in Tibet, China, 2021.

In May 2021, two highly pathogenic avian influenza viruses of clade 2. 3. 4. 4 billion were isolated from dead migratory birds and fecal samples obtained in Tibet, China. Importance In this report, 15 H5N8 and two H5N1 highly pathogenic avian influenza viruses of clade 2. 3. 4. 4 billion were isolated from dead migratory birds and fecal samples in Tibet, China. In China, isolates of H5N1 virus of clade 2. 3. 4. 4 billion have been isolated. Our results show that breeding grounds may have a potential pooling effect among avian influenza viruses in diverse migratory populations.

Source link: https://europepmc.org/article/MED/35446151


Genetics of Japanese H5N8 high pathogenicity avian influenza viruses isolated in winter 2020-2021 and their genetic relationship with avian influenza viruses in Siberia.

Multiple outbreaks of H5N8 high pathogenicity avian influenza in Japan in winter 2020-2021, 52 outbreaks at poultry farms and 58 cases in wild birds or the environment, which coincided with outbreaks in Europe in winter 2020-2021. Here's a look at how the H5N8 HPAI viruses grew and spread through Japan and the Eurasian continent. The viruses that contained the E3 genotype were found to have caused the bulk of the HPAI outbreaks in poultry farms and were found over the longest period of time. The virus's internal genomes of the virus were found to be identical to those of AIVs isolated by avian influenza surveillance programs in Siberia's rural areas of Buryatia, Yakutia, and Amur regions, indicating that the Japanese viruses originated from reassortment events with AIVs genetically similar to Siberian AIVs. These findings indicate that the viruses in wild birds during summer in Siberia most likely spread in both Asia and Europe the following winter.

Source link: https://europepmc.org/article/MED/35445801

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions