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Avian Influenza - BioRxiv

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Last Updated: 08 November 2021

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Computational analysis of the adaptability of H9N2 avian influenza virus: A comparative docking simulation study

Influenza A virus, the H9N2 subtype, is an avian influenza virus that has long been flowing in the around the world fowl market and is occasionally discovered to be transmissible to people. Nevertheless, as a result of the absence of a structural model of the communication between H9N2 and host cells, the mechanism of the substantial flexibility and solid makeover capacity of H9N2 is not completely recognized. In this paper, we gathered 40 representative H9N2 virus examples reported just recently, mainly in China and neighboring countries, and explored the communications between H9N2 hemagglutinin and the animal receptor, the polysaccharide -2,6-connected lactoseries tetrasaccharide c, at the atomic level using docking simulation devices. The calculations showed that all the studied H9N2 infections can establish a tight binding with LSTc although the anomalies created a variety of perturbations to the neighborhood conformation of the binding pocket.

Source link: https://doi.org/10.1101/2020.05.21.108233

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions