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Avian Influenza - BioProject

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Last Updated: 08 November 2021

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Dual host and pathogen RNA-Seq analysis unravel chicken genes potentially involved in resistance to highly pathogenic avian influenza virus infection

Extremely pathogenic avian influenza infections trigger extreme systemic condition and high mortality rates in poultries resulting in substantial financial influence in the fowl industry. This study focused on reviewing the mechanisms behind HPAIV disease resistance. Hens of various types were tested with H7N1 HPAIV or clade 2. 3. 4. 4 b H5N8 HPAIV, euthanized at 3 days post-inoculation, and identified as vulnerable or resistant depending on the adhering to requirements: poultries that provided i medical indications, ii histopathological lesions, and iii existence of HPAIV antigen in cells were categorized as susceptible, while hens doing not have all these criteria were categorized as resistant. No substantial adjustments were located in the viral segments that communicate with the inherent immune response and with the host cell receptors, strengthening the duty of the host in the professional end result.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/774029


Dual host and pathogen RNA-Seq analysis unravel chicken genes potentially involved in resistance to highly pathogenic avian influenza virus infection

Very pathogenic avian influenza viruses trigger extreme systemic illness and high mortality rates in poultries leading to substantial economic effect in the fowl industry. This study targeted at reviewing the mechanisms behind HPAIV disease resistance. Hens of various types were tested with H7N1 HPAIV or clade 2. 3. 4. 4 b H5N8 HPAIV, euthanized at 3 days post-inoculation, and classified as at risk or resistant relying on the adhering to requirements: poultries that offered i medical signs, ii histopathological lesions, and iii existence of HPAIV antigen in tissues were categorized as susceptible, while chickens doing not have all these criteria were identified as immune. We identified small transcriptomic modifications from immune hens on the other hand with massive alterations observed in vulnerable hens. No substantial adjustments were discovered in the viral sections that communicate with the inherent immune response and with the host cell receptors, enhancing the duty of the host in the professional result.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/773364

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions