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Avian Influenza - Astrophysics Data System

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Last Updated: 08 May 2022

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Interventions for avian influenza A (H5N1) risk management in live bird market networks

H5N1 is an epidemic in Asia, with live bird trade as a key disease transmission route. In northern Vietnam, a cross-sectional survey was conducted to determine the overall viability of the live bird market contact network and virus transmission. based on the trade of traders between LBMs and LBMs, weighted and directed networks were created and used for social network analysis and individual-based modeling. Most LBMs were linked to one another, indicating that the LBM network could facilitate large-scale disease dissemination. Some LBMs that have been banned are still working, and they could have a major effect on disease progression, with the highest levels of susceptibility and infectiousness. The number of trader visits to markets, along with data that can be obtained quickly and efficiently, can help identify LBMs that are appropriate for carrying out interventions.

Source link: https://ui.adsabs.harvard.edu/abs/2013PNAS..110.9177F/abstract


Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model

In the ferret model, we reported that a reassortant virus made up of wild-type avian H9N2 surface genes in a seasonal human H3N2 backbone could result in efficient respiratory droplet transmission. We find the ability of the H9N2 surface genes in the context of a pH1N1 virus's internal genes to efficiently transmit ferrets by respiratory droplets in ferrets. In the background of a pH1N1 virus, we isolated reassort viruses carrying the HA gene alone or in combination with the NA gene of a prototypical H9N2 virus.

Source link: https://ui.adsabs.harvard.edu/abs/2011PNAS..10812084K/abstract


Survival of Highly Pathogenic Avian Influenza H5N1 Virus in Tissues Derived from Experimentally Infected Chickens

In this research, we investigated the virus' survival in feather, muscle, and liver tissues obtained from six chickens experimentally infected with HPAI H5N1 virus. Our experimental results show that tissue type and temperature can play a significant role in HPAI H5N1 virus survival in infected chickens' tissues. IMPORTANCE The H5N1 subtype of the highly pathogenic avian influenza virus can cause significant losses of poultry, and people must deal with a large number of chicken carcasses that have been contaminated with the virus at outbreak sites. This review examined how long the virus can maintain its infectivity in the three types of tissues that are related to chickens infected with the virus. Our findings are important for improving understanding viral ecology in the environment and reducing the likelihood of the virus spreading via bird tissues contaminated with the virus.

Source link: https://ui.adsabs.harvard.edu/abs/2017ApEnM..83E.604Y/abstract


Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype

By acquiring a polybasic HA cleavage site, low-pathogenic avian influenza viruses evolving from low-pathogenic precursors naming the HA serotypes H5 or H7 in the HA serotypes H5 or H7. We investigated why compatibility of a polybasic cleavage site with H5/H7 HA only as the reason for this serotype restriction was unclear, as well as a unique predisposition of these two serotypes for insert mutations. We also included a polybasic cleavage site in the HA of several low-pathogenic avian strains with serotypes H2, H3, H6, H10, H14, or H15, as well as rescue HA reassortants after cotransfection with the genes from either a low-pathogenic H9N2 or high-pathogenic H5N1 strains. Two mutations were identified in the M2 proton channel gate region, which is present in several HPAIVs of various origins.

Source link: https://ui.adsabs.harvard.edu/abs/2012PNAS..109.2579V/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions