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Autism Spectrum Disorder - Astrophysics Data System

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Last Updated: 10 May 2022

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Differences in the right inferior longitudinal fasciculus but no general disruption of white matter tracts in children with autism spectrum disorder

A decrease in the integrity of long-range white-matter fiber tracts is one of autism spectrum disorder's most common brain "signatures" of autism spectrum disorders. These results contradict ASD's assertion that widespread shifts in white-matter stability are a hallmark of ASD, and they show how matching for data quality is crucial in future diffusion studies of ASD and other medical disorders.

Source link: https://ui.adsabs.harvard.edu/abs/2014PNAS..111.1981K/abstract


Toward mapping pragmatic impairment of autism spectrum disorder individuals through the development of a corpus of spoken Japanese

The aim of this study is to establish a framework of annotation scheme design and corpus construction that can help identify occurrences of PI in Japanese ASD language, which allows for comprehensive mapping of PI. Since the system network covers all potential lexicogrammatical options in linguistic interaction, it provides a detailed account of where and when lexicogrammar PI occurs. We successfully produced the Corpus of ASD+ Typically Developed Spoken Language, which contains excerpts from 1,187 audiotaped tasks executed by 186 ASD and 106 commonly developed subjects, with approximately 1. 07 million morphemes. Our model corpus is appropriate to any language by incorporating our method of constructing the annotation scheme, and it would give rise to defining PI from a cross-linguistic perspective, which is important because PI of ASD represents cross-linguistic differences.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1764204K/abstract


Relation between acquisition of lexical concept and joint attention in children with autism spectrum disorder without severe intellectual disability

From early childhood, autism spectrum disorder, joint vision impairment, and language development are all present in children with autism spectrum disorder. In 113 Japanese children with ASD, the connection between joint interest and the ability of conceptual inference is investigated in this paper, which is continuing research. The degree of joint attention deficit in children of this age group with ASD is negatively related to conceptual inference skills, but not with expressive and receptive language skills, according to new studies.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1766953S/abstract


The role of probiotics in children with autism spectrum disorders: A study protocol for a randomised controlled trial

According to latest reports, microbiota change in children with ASD following probiotic ingestion may alter the balance of microbiota and therefore ASD symptoms. A total of 160 children with ASD will be stratified and distributed to placebo and probiotics groups randomly determined based on the severity of their ASD symptoms. In comparison to education and rehabilitation, the probiotics group would be given probiotics orally twice a day for three months, and the control group will be given a placebo at the same rate. We'll explore the effect of probiotic supplementation on Children with ASD's symptoms with the aim of determining the potential therapeutic effects of additives on ASD and a reference for clinical research in this research.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1763109Z/abstract


Novel probiotic treatment of autism spectrum disorder associated social behavioral symptoms in two rodent models

Autism spectrum disorder has steadily increased in the last decade, and several research investigate how antibiotic use has escalated and resulted in the disruption of the intestinal microbiome, contributing to the development of neurobehavioral symptoms resembling those of ASD. The primary aim of this research was to determine if depletion of the gastrointestinal microbiome by antibiotic therapy could result in ASD-like behavioral changes in adulthood. The present results support the hypothesis that our PM can influence social behavioural changes, and, therefore, reveal its promising therapeutic ability to attenuate ASD's social-affective disturbances.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.5399M/abstract


The oxytocin receptor gene polymorphism rs2268491 and serum oxytocin alterations are indicative of autism spectrum disorder: A case-control paediatric study in Iraq with personalized medicine implications

The OXT receptor mediated OXT's effects on the social brain. In a pediatric population in Iraq, the clinical value of blood OXT serum levels and the OXT receptor genotype was determined by this research. Using odd ratios with 95% confidence intervals and the Chi-square test, the importance of genotype and allele distributions in various patient groups was determined. Patients with ASD had elevated OXT levels that were significantly higher than those with controls. The OXT scores were highly different within stratified ASD severity groups—within stratified ASD severity groups. ASD patients had a significantly lower genotype CC frequency and a significantly higher prevalence of the heterozygous CT genotype relative to controls, according to a OXTR gene rs2268491 genotyping. Subjects with ASD were the highest OXT levels with the TT genotype. In ASD males, the T allele frequency was higher. Compared to females, ASD males had significantly reduced CC genotype distribution relative to females. Whereas the CT genotype was significantly higher in autistic males than in females, it was also higher in autistic males than in females compared to females. Conclusion Peripheral OXT levels and OXTR genetic variations could be predictive biomarkers of social functioning in the ASD patient population. Patients with ASD are classified into severity groups, which can be gender dependent. Patients with ASD who need neuropeptide therapy in social settings will need personalized medicine strategies to properly identify patients with ASD.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1765217A/abstract


Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders

Autism is a heterogeneous disorder with multiple socioeconomic and biological phenotypes. In a large sample of 2-to-four-year old boys and girls with autism spectrum disorder [n = 53, no change; regression = 61, regression ] and a comparison group of age-matched traditionally developing controls analyzed the correlation between total brain mass and onset status [n = 61, regression; regression = 61, regression ] and a comparison group of age-matched typically developing controls. We found that abnormal brain enlargement was most common in boys with regressive autism. Boys with no regression did not differ from controls, according to the brain size. Head circumference in boys with regressive autism is normal at birth, but diverges from the other groups around 4-6 months of age. There were no differences in brain size in girls with autism. Divergence in brain size occurs in brain development long before skills loss is common.

Source link: https://ui.adsabs.harvard.edu/abs/2011PNAS..10820195N/abstract


Promoting social behavior with oxytocin in high-functioning autism spectrum disorders

Despite retained intellectual capabilities, people with autism spectrum disorder or Asperger syndrome are unable to comprehend or participate in social situations. We looked at the behavioral consequences of oxytocin in 13 children with autism. We discovered that patients had improved interactions with the most socially cooperative partner during oxytocin inhalation, triggering new feelings of trust and preference. Patients respond more consciously to others and exhibit more appropriate social habits and affect under oxytocin, resulting in a therapeutic potential of oxytocin by its intervention on a key dimension of autism.

Source link: https://ui.adsabs.harvard.edu/abs/2010PNAS..107.4389A/abstract


CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

Following CHD8 bandown, we found that the molecular mechanism by which CHD8 affects neurodevelopmental pathways could have both direct and indirect consequences, with the former involving down-regulation following CHD8 suppression. We show that reduced expression of CHD8 produces a variety of other functionally distinct ASD-related genes, meaning that the numerous functions of ASD risk factors may lead to several methods of triggering a smaller number of definitive common pathways.

Source link: https://ui.adsabs.harvard.edu/abs/2014PNAS..111E4468S/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions