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Auranofin - OSTI GOV

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Last Updated: 04 March 2022

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Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase

Here we have therefore used extended X-ray absorption fine structure as a direct structural probe to look at binding to the selenium site in recombinant rat thioredoxin reductase 1. Both methylmercury and auranofin were found direct and complete binding of the inhibitors to the selenium atom in TrxR1 for both methylmercury and auranofin, indicating that TrxR1 inhibition can be attributed to such direct metal-selenium binding.

Source link: https://www.osti.gov/biblio/1617012

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions