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ASTAXANTHIN - PubMed

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Last Updated: 04 September 2022

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Aligned with sustainable development goals: microwave extraction of astaxanthin from wet algae and selective cytotoxic effect of the extract on lung cancer cells.

The bulk of processing expenses are related to algae degradation downstream. This research was designed to determine operating conditions for astaxanthin extraction from wet Haematococcus pluvialis using microwave-assisted extraction. The isolated astaxanthin extract was tested for cytotoxicity on human lung cancer cells by cytotoxicity. These results indicated that astaxanthin extracted from wet H. pluvialis by microwave-assisted extraction had anti-cancer activity on lung cancer cells, indicating a new possibility to be applied in industry.

Source link: https://doi.org/10.1080/10826068.2022.2116455


Engineering Milk-Derived Exosome for Enhancing Cellular Astaxanthin Delivery.

We designed the targeted hyaluronic acid -modified milk exosome-based astaxanthin delivery system in this work to enhance the biocompatibility stability and astaxanthin delivery properties. The targeted delivery system had built up in RAW264. 7 macrophages, and the targeting effect on inflammatory cells had been significantly enhanced, according to fluorescence photographs. In a lipopolysaccharide-induced cell model, the delivery system could enhance the cellular uptake of astaxanthin and reduce reactive oxygen species overproduction, delayed degradation of mitochondrial membrane potential, and mitochondrial membrane potential.

Source link: https://doi.org/10.1021/acs.jafc.2c03683


Astaxanthin Inhibits Matrix Metalloproteinase Expression by Suppressing PI3K/AKT/mTOR Activation in Helicobacter pylori-Infected Gastric Epithelial Cells.

In gastric epithelial cells, we previously reported that H. pylori triggered mitogen-activated protein kinase as well as increased MMP-10 expression. Astaxanthin, a xanthophyll carotenoid, shows antioxidant activity by lowering ROS levels in gastric epithelial cells infected with H. pylori. In H. pylori-infected gastric epithelial AGS cells, this study sought to determine whether astaxanthin inhibits MMP expression, cell proliferation, and migration by lowering the PI3K/AKT/mTOR signaling. Astaxanthin inhibited MMP expression, cell proliferation, and migration in H. pylori-stimulated gastric epithelial AGS cells, facilitating cell proliferation and migration by inhibiting PI3K/AKT/NF-u03bb signaling.

Source link: https://doi.org/10.3390/nu14163427


Choroidal Changes in Blood Flow in Patients with Intermediate AMD after Oral Dietary Supplement Based on Astaxanthin, Bromelain, Vitamin D3, Folic Acid, Lutein, and Antioxidants.

Background and Objectives: The aim of this review was to investigate the effects of oral administration of astaxanthin, lutein, folic acid, vitamin D3, and bromelain with antioxidants on choroidal blood flow in patients with age-related intermediate macular degeneration. Patients with intermediate AMD and treated with a daily oral nutritional supplement containing AXT, bromelain, vitamin D3, folic acid, lutein, and antioxidants for a period of at least six months were included in this retrospective review. CCVD values revealed statistically significant difference between patients and controls at baseline and in the cases during follow-up. Conclusions: The combination of structural OCT and OCTA allows for a comprehensive review of perfusion parameters of the choriocapillaris and choroid chorio, as well as the monitoring of choroidal blood flow changes after oral nutritional supplements that influence blood flow velocity.

Source link: https://doi.org/10.3390/medicina58081092


Property and Stability of Astaxanthin Emulsion Based on Pickering Emulsion Templating with Zein and Sodium Alginate as Stabilizer.

APEs with an encapsulation ratio of 8. 8 percent was up to 86. 7 %, with a mean particle size of 4. 763 u03bcm. Under scanning electron microscope images, freeze-dried APEs particles were stacked together, under scanning electronic microscope, while dispersed spherical nanoparticles were observed in APEs dilution, while dispersed spherical nanoparticles were found in APEs dilution in APEs, although dispersed spherical nanoparticles were detected in APEs dilution. According to Confocal laser scanning microscope images, zein particles loaded with Asta were clumped with SA coating. APEs maintained high Asta retention and antioxidant activity when heated from 50 to 10 u00b0C, relative to bare Asta extract and bare Asta extract. Our findings indicate that the potential use of Asta-loaded Pickering emulsion in food systems as a fortified additive.

Source link: https://doi.org/10.3390/ijms23169386


Biological Extraction, HPLC Quantification and Medical Applications of Astaxanthin Extracted from Crawfish "Procambarus clarkii" Exoskeleton By-Product.

Astaxanthin extraction's primary challenge is to produce an environmentally friendly method of extraction rather than harmful chemical methods that threaten human health. This research demonstrated an eco-friendly method for astaxanthin extraction using two bacterial and fungal probiotics as well as determining the astaxanthin concentration by high-performance liquid chromatography analysis. Also, the IC50 values of human liver cancer cell line, human hepatocellular carcinoma, and breast cancer cell line MCF-7 were 24 u00b5g/mL, 11 u00b5g/mL, and 9. 9 g/mL, respectively. At 100 g/mL of exoskeleton containing astaxanthin, the lowest cell viability percentage was 19%.

Source link: https://doi.org/10.3390/biology11081215


The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy.

In a group of people with mild myopathy, we sought to investigate the mid- and long-term physiological effects of monacolin k and astaxanthin supplements in association with a low-energy/fat diet. Participants were drawn to the experimental group with a low-energy/fat diet in combination with monacolin k and astaxanthin supplementation, as well as astaxanthin supplementation, but only with a low-energy/fat diet. In combination with a low-energy/fat diet in the treatment of dyslipidemia, our results show the effectiveness and safety of combined use of monacolin k and astaxanthin.

Source link: https://doi.org/10.3390/biom12081118


Astaxanthin Carotenoid Modulates Oxidative Stress in Adipose-Derived Stromal Cells Isolated from Equine Metabolic Syndrome Affected Horses by Targeting Mitochondrial Biogenesis.

This research was conducted to see if astaxanthin could shield adipose-derived stromal stem cells from apoptosis, mitochondrial dysfunction, and oxidative stress. After 24, 48 and 72 hours of incubation with the cells, no adverse effect was found; Phaffia rhodozyma was used to extract astaxanthin, whose biocompatibility was tested. ASCs were treated with optimal astaxanthin levels. Astaxanthin's results show that astaxanthin can be used to reduce and reduce oxidative stress, thus improving the overall metabolic stability of equine ASCs suffering from metabolic syndrome.

Source link: https://doi.org/10.3390/biom12081039


The Effect of Astaxanthin on Motility, Viability, Reactive Oxygen Species, Apoptosis, and Lipid Peroxidation of Human Spermatozoa During the Freezing-Thawing Process.

Cryopreservation of spermatozoa is a common procedure used to ensure sperm for an indefinite period of time. Despite the effectiveness of sperm cryopreservation, overactive reactive oxygen species production during cryopreservation can cause behavioural and functional shifts in spermatozoa. Hence, this research was designed to investigate the impact of AXT on healthy males during freezing-thawing. In the first phase, ten semen samples with different amounts of AXT were cryopreserved to produce the highest dose of AXT. All parameters of sperm motility and viability were enhanced by the addition of 1 bcM AXT to sperm freezing media, according to our results. Also, AXT reduced the amount of PS externalization and LPO after the freezing process, which was also reduced. In conclusion, our results showed that human semen therapy prior to the freezing-thawing process has antioxidant benefits against oxidative stress, as well as decreasing the damaging effects of this process on sperm quality.

Source link: https://doi.org/10.1089/bio.2021.0112


Astaxanthin Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Intestinal Flora and Targeting the AMPK/Nrf2 Signal Axis.

Nonalcoholic fatty liver disease is one of the most common chronic liver diseases worldwide. Astaxanthin is a carotenoid extracted from shrimps and crabs with beneficial biological properties, including anti-oxidative and anti-inflammatory activity. Significant improvements in the model mouse's gut flora were also found due to AT. In oleic acid and palmitic acid-induced HepG2 cells, AT significantly reduced the protein expression level of fatty acid synthetase, sterol regulatory element-binding protein-1c, acetyl-COA carboxylase, and acetyl-COA carboxylase, as well as raised the protein expression of nuclear factor-E2 associated factor 2 and AMP-activated protein kinase. In addition, mechanistic experiments showed that compound C inhibited AT's regulatory action on the SREBP-1c and Nrf2 signaling pathways.

Source link: https://doi.org/10.1021/acs.jafc.2c04476

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions