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Aspergillosis - Springer Nature

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Last Updated: 06 June 2022

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Occurrence of Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Patients with Allergic Bronchopulmonary Aspergillosis Complicating Asthma

"Background Whether cystic fibrosis transmembrane conduct regulator gene mutations contribute to the high incidence of allergic bronchopulmonary aspergillosis in India remains unclear. " We wanted to investigate the presence of CFTR mutations in patients with ABPA-complexing asthma in children. On the Illumina NextSeq500 platform, we sequenced the CFTR gene using genomic DNA from blood. The known or novel single nucleotide polymorphisms and indels were identified prior to doing zygosity analysis by genome analysis software kit. SNPs in asthmatic patients were higher than those in ABPA or healthy controls, but not statistically significant. In four studies with no corresponding reference SNP, two novel SNPs were found. In ABPA subjects with high-attenuation mucus and bronchiectasis, the number of SNPs was higher than serological ABPA. Conclusions Our research shows the role of CFTR mutations in the pathogenesis of ABPA. SNPs in the CFTR gene may cause disease severity in ABPA. ".

Source link: https://doi.org/10.1007/s11046-022-00631-y


Intracranial aspergillosis in immunocompetent adult patients without risk factors: a systematic review

"The clinical signs and prognostic factors of intracranial aspergillosis in immunocompetent patients without risk factors are not well understood," the author says. Intracranial mass, pure intraparenchymal disease, meningoencephalitis, and a dural-based mass were among the intracranial aspergillosis types. Patients with meningoencephalitis had the highest mortality rate. The latest findings from the current research may help anticipate patient prognosis at the time of diagnosis and identify potential prognostic factors. ".

Source link: https://doi.org/10.1007/s10143-022-01738-y


Evaluation of the Dynamiker^® Fungus (1–3)-β-d-Glucan Assay for the Diagnosis of Invasive Aspergillosis in High-Risk Patients with Hematologic Malignancies

"Introduction Laboratory The Dynamiker's Fungus Assay (d -glucan assay) allows the testing of samples in smaller batches as compared to the well-established Fungitellu00ae assay, making the assay cost-effective in centers with small numbers of samples. " IA testing was performed on 60 adult hematology patients, 13 with probable IA, 19 with possible IA, 19 with suspected IA, 19 with possible IA, and 28 with no IA. Serum specimens were collected twice-weekly and tested for u03b2 -glucan using FA and DFA, which were compared quantitatively with Spearman rank correlation analysis and qualitatively with the Chi-square test, respectively. With DFA than FA, BDG levels were lower than FA compared to FA. The optimal BDG positivity threshold set did not result in significant test quality improvement for either assay or placebo. However, a greater % of patients with suspected IA had u22652 consecutive positive specimens in comparison to patients with no IA, resulting in increased sensitivity and NPV.

Source link: https://doi.org/10.1007/s40121-022-00627-7


Heterogeneous imaging features of Aspergillosis at ^18F-FDG PET/CT

"Aspergillosis is one of the most common fungal infections, whose morbidity can be life-threatening, particularly in immunocompromised patients. 18F-FDG PET/CT is a whole-body diagnostic system that can aid in the diagnosis of the disease, as well as guiding patient management due to the ability to identify infection sites and extension. Literature describing all of its potential characteristics, both common and unusual, has been updated to include imaging interpretation. In addition, other PET/CT radiopharmaceutical contributions in Aspergillosis imaging research have been highlighted. ".

Source link: https://doi.org/10.1007/s40336-022-00497-6


T-cell epitope-based vaccine prediction against Aspergillus fumigatus: a harmful causative agent of aspergillosis

Aspergillus fumigatus is one of the most common causes of invasive aspergillosis and acute bronchopulmonary aspergillosis. Allogeneic haematopoietic stem cell transplant recipients, HIV patients, and cancer patients with A. fumigatus suffer severe aspergillosis. A. fumigatus is a common allergy among Asthmatics and cystic fibrosis patients. MHC class-III binding epitopes can cause immunogenic reactions in patients. In a docked state, atomic contact energy value for these five epitopes is shown below u22125 Kcal/mol. "Underground Aspergillosis and acute bronchopulmonary aspergillosis are caused by the dangerous fungal pathogen Aspergillus fumigatus. ".

Source link: https://doi.org/10.1186/s43141-022-00364-x

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions